DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXE and CG32305

DIOPT Version :9

Sequence 1:	NP_652601.3	Gene:	ACXE / 53426	FlyBaseID:	FBgn0040506	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	NP_728725.2	Gene:	CG32305 / 317967	FlyBaseID:	FBgn0052305	Length:	1164	Species:	Drosophila melanogaster

Alignment Length:	1152	Identity:	388/1152 - (33%)
Similarity:	598/1152 - (51%)	Gaps:	111/1152 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LNYSKERMWEPGYLKAKCAELRLE-SEFRLYRIRLWKSYLLTFFMLHIFVTSVHCALLLATIERR 73
            |:..|:..|.  :||.||..|||| :..||..:.|..:.:...:.:.:.:.: |..||||.::..
  Fly    18 LSTVKDLEWR--HLKNKCQNLRLELACSRLRELALMSNVVQIIWHVELLMVA-HVILLLALVKDI 79

  Fly    74 SII----YFDVALSIGCALVLILVLSVNFCDEFIAKHTWYMYASSIFASLTLVFADLTESIYHTY 134
            .::    ||.|.|.....::|.:..:|......:.  :|.|  :....|:.|| :||..:||...
  Fly    80 ILVTMVPYFAVMLFSPFIMLLSMQNNVGMITNTLI--SWLM--ALFLTSMDLV-SDLLGTIYSGA 139

  Fly   135 AHSWILGTFYDTYIIYMIYMFLPIHFISGA--VLLALLVSGLYILYFVIFIAQGFAQFASALFSV 197
            |:..:  ..||..::..:||.|||.|..|:  .:|.::||.:||.|..      :.|:.:...|.
  Fly   140 AYPTV--PCYDHVVLVSVYMTLPIAFYQGSSVYVLGMVVSIIYIGYAF------YMQYLNDQVSF 196

  Fly   198 GGMSVDIVHYLCLNLVGIFYRVMNDTVVRSSFLDRHQYIKEKIWLRNARLQEKQLLDSILPPQIS 262
            ..::...::...|||:..|:.::.|..:|.:.|.|:|.:.:.|..:....:|..||:||||.::.
  Fly   197 YLLASYAIYLFTLNLIFSFFTIIRDYGLRRAILSRYQLVYQNIVYQLVMKKENGLLESILPRKMI 261

  Fly   263 LPLQKDIQGRIVMAKQGIHSWTAMERTMAIQIHPDVSILYADVVNYTHLTTTLTVEMLVKVLHDL 327
            ..||::|..||....:......|..|.:.::.:|:||||.||:||||||||||....||::||||
  Fly   262 RTLQEEICSRIEDQDKNFTPSKAGLRKLFLEPYPNVSILVADMVNYTHLTTTLEAPQLVEILHDL 326

  Fly   328 YGRFDLAAYRYKVQRIKFLGDCYYCVAGLSDPDPDHANNCVILGLSMINHIMEVRDIHGLDINMR 392
            :..|||||.|.:..|||||||.|.||||:.:..|.||:.||...|.||:....|.....||||:|
  Fly   327 FVNFDLAANRNRAMRIKFLGDSYNCVAGIPNYFPAHASCCVDQALEMIHITQGVSSRRELDINLR 391

  Fly   393 IGVHSGNLFAGVIGEAKLQFDIWGLDVTIANVLESTGVPGCVHISGATLNNLDVNRFDIEDGPEE 457
            ||||||.:|||:||..|.|||||..||.|.|.|||:|:||.||:|..||:.|| ..:...:|.|.
  Fly   392 IGVHSGEVFAGIIGHTKWQFDIWSKDVDITNRLESSGLPGLVHVSQRTLSMLD-EHYIFREGTEA 455

  Fly   458 ARDHPLLKKYRIRSYIIRQDL-------HMDDEDSDEFLGDLHSISLCNM---GAQPRISDSANQ 512
            |::.|:|::..||::::...|       .:|||.|..      ||:.|.:   |....|...|.:
  Fly   456 AKNDPILQQAGIRTFLVSNRLPDAVEPGELDDELSSA------SINSCRLSYGGYYEEIQIKAQR 514

  Fly   513 SLRALFHEELREEFRKMPVSAFSPKRLLGIC-----RFNTGKEVPAHQNLNICLTFTDPI----- 567
                    |:.:|..:|.|         |.|     |.::.|:    |:.|....|::.|
  Fly   515 --------EIMKEVDQMAV---------GHCFIEWRRSSSMKK----QDFNEEYLFSNQIHLVLG 558

  Fly   568 LERAYLKQ------TDYMYKYSIILSASVGCSLVYIELMDTQMICSSCFVLPASVATIQCILALI 626
            :.|::.::      .|.|.||:::|....|.:::.|.|::.........:|  .:..|..||.::
  Fly   559 VFRSWKREWEFHNLPDLMIKYTMLLVLCAGLAIMSINLIEEATYPDILVLL--GILLILLILCIL 621

  Fly   627 AWYKK--YCWTRYGRNNVPHHYNGFSCF----IFRIHDKILNSLPIRICIYLFLMISSFFVMCLI 685
            |.|||  ..|.:....:.|      |||    :.||.::|.:||.:||.:.:.:::..:.:....
  Fly   622 AGYKKLRLQWKKLTPMSQP------SCFLSRWLLRISERIEDSLFVRIPLTMVVLLLLYVMSSQA 680

  Fly   686 VMSCQREEFEMAYIEERLFHYEQEAHICFHPWVTTNMLSLMICLTFTFAHIPIMVKTAVAILETL 750
            |.||...:.|::.||..|::.:..|. ||.||..|..:.::|.|.|.....|:::|....:|...
  Fly   681 VFSCDVAKLELSIIEAHLYNEKSYAE-CFGPWTVTYCVVIVISLLFVVPGCPLVIKILAGLLILG 744

  Fly   751 AYLLLIFFQFDFVFHHSVTTNPYFKSEYAHALLICITFLIMFVKERQIEFTNKVNFNWRVDLRKE 815
            .:|..:...:.|.|..|.||:...||:|||...:...|:::.::||.:.:..|.|:..||...:.
  Fly   745 LHLGTVHLYYGFAFERSETTDLGLKSDYAHTWYLVALFIVLVLRERHVNYLRKFNYFMRVCYEEA 809

  Fly   816 ENAASLTNHSIIIILNNILPSHIVDVYLNSLAKHELYFENYRMVSVMFAMLINFEMDLRSLRVLN 880
            .........||.||:.||||:|:..||.......:||:||:..|:||||.:.||..|...||:|:
  Fly   810 HQQTDEKLRSIKIIMANILPTHVAQVYKVRRPHDQLYYENFSKVAVMFASIENFNADTAGLRILH 874

  Fly   881 EIIAEFDTLLLFYKEYYTVEKIKIVGCTYMAACGLDLNF-------------AGSTSTNRKESIP 932
            |||..||.||:.|:..|.:||||::|.|||.||||:.:.             ...:...|..|:.
  Fly   875 EIICCFDDLLVDYQTRYKIEKIKVMGWTYMVACGLETDHYTDFSIDIPVKQPEADSEIRRGSSVL 939

  Fly   933 PTEF----NEEQSRRILFQQSNEDLDEVVFVMTSYALDMMRTLAKSNEAYQSIAGDRNITDGTIA 993
            ...|    ::|.|...:.|...:..|..|.|||.:|||::|.:......|.....|..:| |::.
  Fly   940 TVHFGSTEDDEMSGDNVSQPYAQVQDVAVLVMTEFALDLLRIMHDIRYNYVFSEYDTFLT-GSLK 1003

  Fly   994 IGISSGEVMAGIVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTEETSEILQQFGITCSYRGMT 1058
            ||||.|.||||:||.|:|||||||:.|||||||.||||..:|.||..|:::|:||.|.|:|||.|
  Fly  1004 IGISHGSVMAGVVGLSKPHYDIWGHTVNMASRMSSTGLLDNIQVTRHTAKVLRQFNIRCNYRGHT 1068

  Fly  1059 FVKGRGKIPTYLVGIDENLNFIPQKATRFPSHQERSTVI-SLQSTYT 1104
            .|||.||:|||||.:|.:|.|.............:|.|| :|..::|
  Fly  1069 EVKGVGKVPTYLVVVDPDLTFQDHDQVSMSMKDSKSWVIDTLSLSFT 1115

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	64/247 (26%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	91/168 (54%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147	106/236 (45%)
CG32305	NP_728725.2	CYCc	251..449	CDD:214485	102/198 (52%)
		Nucleotidyl_cyc_III	292..445	CDD:299850	89/153 (58%)
		CYCc	814..1056	CDD:214485	100/242 (41%)
		Nucleotidyl_cyc_III	845..1081	CDD:299850	106/236 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453917
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	1	1.000	-	-		FOG0007605
OrthoInspector	1	1.000	-	-		otm48748
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.850