Protein Alignment ACXE and Adcy1

DIOPT Version :9

• Sequence 1: NP_652601.3
• Gene: ACXE / 53426
• FlyBaseID: FBgn0040506
• Length: 1123
• Species: Drosophila melanogaster
• Sequence 2: NP_001100709.1
• Gene: Adcy1 / 305509
• RGDID: 1309318
• Length: 967
• Species: Rattus norvegicus
• Alignment Length: 1033
• Identity: 276/1033 - (26%)
• Similarity: 460/1033 - (44%)
• Gaps: 256/1033 - (24%)

  Fly   148 IIYMIYMFLPIHFISGAVLLALLVSGLYILYFVIFIAQGFAQF-----ASALFSVGGMSVDIVHY 207
            :.::.|..||:..:. |:...|:|:..::|.....:.....:.     |:||...|
  Rat    16 VTFVSYALLPVRSLL-AIGFGLVVAASHLLVTAALVPAKRPRLWRTLGANALLFFG--------- 70

  Fly   208 LCLNLVGIFYRVMNDTVVRSSFLDRHQYIKEKIWLRNARLQEKQLLDSILPPQISLPLQKDIQGR 272
              :|:.|:|.|::.:...|.:||.....|::::.|.:...::::||.|:||..:::.:::|.
  Rat    71 --VNMYGVFVRILTERSQRKAFLQARNCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDF--- 130

  Fly   273 IVMAKQGIHSWTAMERTMAIQIHPDVSILYADVVNYTHLTTTLTVEMLVKVLHDLYGRFDLAAYR 337
            :...::..|.       :.||.|.:||||:||:|.:|.|.:..|.:.|||:|::|:|:||..|..
  Rat   131 LKPPERIFHK-------IYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATE 188

  Fly   338 YKVQRIKFLGDCYYCVAGLSDPDPDHANNCVILGLSMINHIMEVRDIHGLDINMRIGVHSGNLFA 402
            ...:|||.||||||||:||:.|..|||:.||.:||.||:.|..|.:...:|:|||:|:|:|.:..
  Rat   189 NHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLC 253

  Fly   403 GVIGEAKLQFDIWGLDVTIANVLESTGVPGCVHISGATLNNLDVNRFDIEDGPEEARD-----HP 462
            ||:|..|.|:|:|..|||:|||:|:.|:||.|||:..||..|: ..:::|.|....|:     |.
  Rat   254 GVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLN-GDYEVEPGHGHERNTFLRTHN 317

  Fly   463 L---------------------LK-----KYRIRSYIIRQDLHMDDEDSDEFLGDLHSISLCNMG 501
            :                     :|     |::...|::.|.:|.......|.  ...::..|.
  Rat   318 IETFFIVPSHRRKIFPGLILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEI--PFSNVMTCE-- 378

  Fly   502 AQPRISDSANQSLRALFHEELREEFRKMPVSAFSPKRLLG---------ICRFNTGKEVPAHQ-N 556
                 .|...::||.. .|:||..      |:||...:..         |.|....::..... :
  Rat   379 -----DDDKRRALRTA-SEKLRNR------SSFSTNVVYTTPGTRVNRYISRLLEARQTELEMAD 431

  Fly   557 LN-ICLTFTDPILERAYLKQTDYMYKYSIILSASVGC--SLVYIELMDTQMICSSCFVLPASVAT 618
            || ..|.:.....|:.|.:..|..:..:::|:..:..  .|:|:            .|:|.|||.
  Rat   432 LNFFTLKYKHVEREQKYHQLQDEYFTSAVVLALILATLFGLIYL------------LVIPQSVAV 484

  Fly   619 IQ------CILALIAWYKKYCWTRYGRNNVPHHYNGFSCFIFRIHDKILNSLPIRICIYLFLMIS 677
            :.      |.|.....|.              |.....||...:..:|..:|    |:::.::|.
  Rat   485 LLLLVFSICFLVACTLYL--------------HITRVQCFPGCLTIQIRTAL----CVFIVVLIY 531

  Fly   678 SFFVMCLIVMSCQREEFEMAYIEERLFHYEQEAHICFHPWVTTNMLS------------------ 724
            |....|  |:||.                         ||..::..:
  Rat   532 SVAQGC--VVSCL-------------------------PWAWSSHSNSSLVVLAAGGRRTVLPAL 569

  Fly   725 --------LMICLTFTFAHIPIMVKTAVAILE--------TLAYLLLIFFQFDFVFHHSVTTNPY 773
                    |:.||..|   :|:.:...|:.|.        |.:|:|::    :...:..|.....
  Rat   570 PCESAHHGLLCCLVGT---LPLAIFLRVSSLPKMILLSGLTTSYILVL----ELSGYTKVGGGAL 627

  Fly   774 FKSEYAHALLICITFLIMFVKERQIEFTNKVNFNWRVDLRKEEN---AASLTNHSIIIILNNILP 835
            ....|...:.|.:....:.:..||::...::::.|.....:|.:   ...|.|..|:.   |:||
  Rat   628 SGRSYEPIMAILLFSCTLALHARQVDVRLRLDYLWAAQAEEERDDMERVKLDNKRILF---NLLP 689

  Fly   836 SHIVDVYLNSLAKH-ELYFENYRMVSVMFAMLINF----------EMDLRSLRVLNEIIAEFDTL 889
            :|:...:|.|..:: :||:::|..|.||||.:.||          .|.:..||:||||||:||.|
  Rat   690 AHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDEL 754

  Fly   890 L--LFYKEYYTVEKIKIVGCTYMAACGLDLNFAGSTSTNRKESIPPTEFNEEQSRRILFQQSNED 952
            :  .|||:   :||||.:|.|||||.||    |.:..|..|:||
  Rat   755 MDKDFYKD---LEKIKTIGSTYMAAVGL----APTAGTRAKKSI--------------------- 791

  Fly   953 LDEVVFVMTSYALDMMRTLAKSNEAYQSIAGDRNITDGTIAIGISSGEVMAGIVGASQPHYDIWG 1017
             ...:..:..:|:||...|.:.|  |||      ..|..:.:||:.|.|:||::||.:|.|||||
  Rat   792 -SSHLSTLADFAIDMFDVLDEIN--YQS------YNDFVLRVGINVGPVVAGVIGARRPQYDIWG 847

  Fly  1018 NPVNMASRMESTGLPGHIHVTEETSEILQQFGITCSY----RGMTFVKGRGKIPTYLV 1071
            |.||:||||:|||:.|.|.||||...:|.:    |||    ||...|||:|::.||.:
  Rat   848 NTVNVASRMDSTGVQGRIQVTEEVHRLLNR----CSYQFVCRGKVSVKGKGEMLTYFL 901

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	26/128 (20%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	79/168 (47%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147	93/235 (40%)
Adcy1	NP_001100709.1	AC_N	<6..139	CDD:292831	26/137 (19%)
		CYCc	105..300	CDD:214485	84/205 (41%)
		Guanylate_cyc	141..323	CDD:278633	81/182 (45%)
		CYCc	673..884	CDD:214485	94/254 (37%)
		Guanylate_cyc	706..903	CDD:278633	93/237 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910