DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXE and GUCY2D

DIOPT Version :9

Sequence 1:	NP_652601.3	Gene:	ACXE / 53426	FlyBaseID:	FBgn0040506	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	NP_000171.1	Gene:	GUCY2D / 3000	HGNCID:	4689	Length:	1103	Species:	Homo sapiens

Alignment Length:	270	Identity:	70/270 - (25%)
Similarity:	113/270 - (41%)	Gaps:	55/270 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   812 LRKEENAASLTNHSIIIILNNILPSHIVDVYLNSLAKHELYFENYRMVSVMFAMLINF------E 870
            :|:......|.......:|..:||..:.:...........|||   .|::.|:.::.|      .
Human   835 IRERTEELELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFE---QVTLYFSDIVGFTTISAMS 896

  Fly   871 MDLRSLRVLNEIIAEFDTLLLFYKEYYTVEKIKIVGCTYMAACGLDLNFAGSTSTNRKESIPPTE 935
            ..:..:.:||::...||.::..:..|    |::.:|..||.|.||.
Human   897 EPIEVVDLLNDLYTLFDAIIGSHDVY----KVETIGDAYMVASGLP------------------- 938

  Fly   936 FNEEQSRRILFQQSNEDLDEVVFVMTSYALDMMRTLAKSNEAYQSIAGDRNITDGTIAIGISSGE 1000
              :...:|...:.:|..||    ::::.....||.:.:              ....|.||:.||.
Human   939 --QRNGQRHAAEIANMSLD----ILSAVGTFRMRHMPE--------------VPVRIRIGLHSGP 983

  Fly  1001 VMAGIVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTEETSEILQQF--GITCSYRGMTFVKGR 1063
            .:||:||.:.|.|.::|:.||.||||||||||..|||...|..||:..  |.....||.|.:||:
Human   984 CVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGK 1048

  Fly  1064 GKIPTY-LVG 1072
            |...|: |||
Human  1049 GAEDTFWLVG 1058

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454
		Nucleotidyl_cyc_III	290..459	CDD:325147
		Nucleotidyl_cyc_III	851..1071	CDD:325147	62/228 (27%)
GUCY2D	NP_000171.1	PBP1_sensory_GC_DEF-like	55..431	CDD:380594
		PK_GC-2D	536..811	CDD:270945
		HNOBA	<820..865	CDD:369471	5/29 (17%)
		CYCc	846..1036	CDD:214485	58/235 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1065..1103
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900