DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ACXE and GUCY2F

DIOPT Version :9

Sequence 1:NP_652601.3 Gene:ACXE / 53426 FlyBaseID:FBgn0040506 Length:1123 Species:Drosophila melanogaster
Sequence 2:NP_001513.2 Gene:GUCY2F / 2986 HGNCID:4691 Length:1108 Species:Homo sapiens


Alignment Length:1087 Identity:220/1087 - (20%)
Similarity:359/1087 - (33%) Gaps:354/1087 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   186 GFAQFASALFSVGGMSVD--IVHYLCLNLV---GIFYRVMNDTV---------VRSSFLDRHQYI 236
            |:.:.||.|    |.|.|  |..:.|:|..   .|.|...:.|:         |...|...|..:
Human   130 GYCEAASLL----GNSWDKGIFSWACVNYELDNKISYPTFSRTLPSPIRVLVTVMKYFQWAHAGV 190

  Fly   237 ---KEKIWLRNARLQEKQLLDSILPPQISLPLQKDIQGRIVMAKQGIHSWTAMERTMAI------ 292
               .|.||:..|......|....||..:.|...:|.|. :..|.|.||.   .:|...|      
Human   191 ISSDEDIWVHTANRVASALRSHGLPVGVVLTTGQDSQS-MRKALQRIHQ---ADRIRIIIMCMHS 251

  Fly   293 -------QIH------------------PDVSILYADVVNYTH-----------------LTTTL 315
                   |:|                  |..::||:  :.|.|                 ...|:
Human   252 ALIGGETQMHLLECAHDLKMTDGTYVFVPYDALLYS--LPYKHTPYRVLRNNPKLREAYDAVLTI 314

  Fly   316 TVEMLVKVLHDLYGRFDLAAYRYKV-QRIKF------LGDCY---YCVAGLSDPDPDHANNCV-- 368
            |||...|.   .|..|..||.|.:: ::::|      .|..|   |.:|       ...||.:  
Human   315 TVESQEKT---FYQAFTEAAARGEIPEKLEFDQVSPLFGTIYNSIYFIA-------QAMNNAMKE 369

  Fly   369 ---ILGLSMINHIMEVRDIHGLDINMRIGVHSGNLFAGVIGEAKLQFDIWGLDVTIA-----NVL 425
               ....|::.|...:: .||.:..||...:...:...||.:..|:  .|.|..|..     .:|
Human   370 NGQAGAASLVQHSRNMQ-FHGFNQLMRTDSNGNGISEYVILDTNLK--EWELHSTYTVDMEMELL 431

  Fly   426 ESTGVPGCVHISGATLNNLD--------------------------------------------V 446
            ...|.|  :|..|......|                                            :
Human   432 RFGGTP--IHFPGGRPPRADAKCWFAEGKICHGGIDPAFAMMVCLTLLIALLSINGFAYFIRRRI 494

  Fly   447 NRFDIEDGPEEARDHPLLKKYRIRSYIIRQDLHMDDEDSDEFLGDLHSISL-----CNMGAQPRI 506
            |:..:..||.             |..:..:|:...:.......|...|:|.     ...|..||:
Human   495 NKIQLIKGPN-------------RILLTLEDVTFINPHFGSKRGSRASVSFQITSEVQSGRSPRL 546

  Fly   507 SDSANQSLRALFHEE---LREE----FRKMPVSAFS-----PKRLLGICRFNTGKEVPAHQNLNI 559
            |.|:.....|.:...   :.|.    .:|..:..|.     ..|...:  |...|:: .|:|:|.
Human   547 SFSSGSLTPATYENSNIAIYEGDWVWLKKFSLGDFGDLKSIKSRASDV--FEMMKDL-RHENINP 608

  Fly   560 CLTF------------------TDPILERAYLKQTDYMYKYSIILSASVGC------SLVYIELM 600
            .|.|                  .:.||....:| .|:|:|.|::|....|.      ..|:..|.
Human   609 LLGFFYDSGMFAIVTEFCSRGSLEDILTNQDVK-LDWMFKSSLLLDLIKGMKYLHHREFVHGRLK 672

  Fly   601 DTQMICSSCFVLPASVATIQCILALI------AWYKKYCWT-----RYGRNNVPHHYNGFSCFIF 654
            ....:....|||..:......||.::      :..::..||     |..|.:....:.| ..:.|
Human   673 SRNCVVDGRFVLKVTDYGFNDILEMLRLSEEESSMEELLWTAPELLRAPRGSRLGSFAG-DVYSF 736

  Fly   655 RIHDKILNSLPIRICIYLFLMISSFFVMCLIVMSCQREEFEMAYIEERLFHYEQEAHICFHPWVT 719
            .|   |:..:.:|...:           |::.:..|.       |..||    ::....:.|.|.
Human   737 AI---IMQEVMVRGTPF-----------CMMDLPAQE-------IINRL----KKPPPVYRPVVP 776

  Fly   720 TNMLSLMICLTFTFAHIP-----IMVKTAVAILETLAYLLLIFFQFDFVFHHSVTTNPYFKSEYA 779
            ..             |.|     :|.:......|...       .||.:|:...|.|...|:...
Human   777 PE-------------HAPPECLQLMKQCWAEAAEQRP-------TFDEIFNQFKTFNKGKKTNII 821

  Fly   780 HALLICI----TFLIMFVKERQIEFTNKVNFNWRVDLRKEENAASLTNHSIIIILNNILPSHIVD 840
            .::|..:    :.|...::||..|.        .::.:|.|.           :|..:||..:.:
Human   822 DSMLRMLEQYSSNLEDLIRERTEEL--------EIEKQKTEK-----------LLTQMLPPSVAE 867

  Fly   841 VYLNSLAKH-ELYFENYRMVSVMFAMLINF------EMDLRSLRVLNEIIAEFDTLLLFYKEYYT 898
                ||.|. .:..|.:.:|::.|:.::.|      ...:..:.:||::...||.::..:..|  
Human   868 ----SLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVY-- 926

  Fly   899 VEKIKIVGCTYMAACGLDLNFAGSTSTNRKESIPPTEFNEEQSRRILFQQSNEDLDEVVFVMTSY 963
              |::.:|..||.|.||                 |.......:..|    :|..||    :::|.
Human   927 --KVETIGDAYMVASGL-----------------PKRNGSRHAAEI----ANMSLD----ILSSV 964

  Fly   964 ALDMMRTLAKSNEAYQSIAGDRNITDGTIAIGISSGEVMAGIVGASQPHYDIWGNPVNMASRMES 1028
            ....||.:.:              ....|.||:.||.|:||:||.:.|.|.::|:.||.||||||
Human   965 GTFKMRHMPE--------------VPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMES 1015

  Fly  1029 TGLPGHIHVTEETSEILQQF--GITCSYRGMTFVKGRGKIPTY-LVG 1072
            ||||..|||:..|..|||..  |.....||.|.:||:|...|: |:|
Human  1016 TGLPYRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETFWLIG 1062

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ACXENP_652601.3 AC_N <31..272 CDD:318454 26/102 (25%)
Nucleotidyl_cyc_III 290..459 CDD:325147 46/280 (16%)
Nucleotidyl_cyc_III 851..1071 CDD:325147 64/228 (28%)
GUCY2FNP_001513.2 PBP1_sensory_GC_DEF_like 54..435 CDD:107366 69/327 (21%)
ANF_receptor 75..412 CDD:279440 64/302 (21%)
PKc_like 545..815 CDD:304357 56/319 (18%)
HNOBA <824..869 CDD:285003 10/67 (15%)
CYCc 848..1040 CDD:214485 65/249 (26%)
Guanylate_cyc 875..1062 CDD:278633 65/229 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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