Protein Alignment ACXE and GUCY1A1

DIOPT Version :10

• Sequence 1: NP_652601.3
• Gene: ACXE / 53426
• FlyBaseID: FBgn0040506
• Length: 1123
• Species: Drosophila melanogaster
• Sequence 2: XP_047306103.1
• Gene: GUCY1A1 / 2982
• HGNCID: 4685
• Length: 767
• Species: Homo sapiens
• Alignment Length: 278
• Identity: 77/278 - (27%)
• Similarity: 136/278 - (48%)
• Gaps: 42/278 - (15%)

  Fly   180 VIFIAQGFAQFASALFSVGGMSVDIV-----HYLCLNLVGIFYRVMNDTVVRSSFLDRHQYIKEK 239
            :|:|.:     :||:..:|...||.:     ..|.|:.:.| :..:.|.|:..........:|::
Human   447 MIYIVE-----SSAILFLGSPCVDRLEDFTGRGLYLSDIPI-HNALRDVVLIGEQARAQDGLKKR 505

  Fly   240 IWLRNARL--------QEKQ----LLDSILPPQISLPLQKDIQGRIVMAKQGIHSWTAMERTMAI 292
            :....|.|        :||:    ||.||.|.:::   |:..||::|.||:
Human   506 LGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVA---QQLWQGQVVQAKK-------------- 553

  Fly   293 QIHPDVSILYADVVNYTHLTTTLTVEMLVKVLHDLYGRFDLAAYRYKVQRIKFLGDCYYCVAGLS 357
              ..:|::|::|:|.:|.:.:..:...::.:|:.||.|||.......|.:::.:||.|....||.
Human   554 --FSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLH 616

  Fly   358 DPDPDHANNCVILGLSMINHIMEVRDIHGLDINMRIGVHSGNLFAGVIGEAKLQFDIWGLDVTIA 422
            .....||....::.|.|:....||...||..|.||||:|||::||||:|....::.::|.:||:|
Human   617 KESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLA 681

  Fly   423 NVLESTGVPGCVHISGAT 440
            |..||..||..:::|..|
Human   682 NKFESCSVPRKINVSPTT 699

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AcyC	65..453	CDD:441717	77/278 (28%)
		Nucleotidyl_cyc_III	290..459	CDD:448371	49/151 (32%)
		Nucleotidyl_cyc_III	851..1071	CDD:448371
GUCY1A1	XP_047306103.1	HNOBA	354..543	CDD:462234	23/104 (22%)
		Guanylate_cyc	549..720	CDD:425528	52/167 (31%)