DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXE and Adcy10

DIOPT Version :9

Sequence 1:	NP_652601.3	Gene:	ACXE / 53426	FlyBaseID:	FBgn0040506	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	NP_766617.2	Gene:	Adcy10 / 271639	MGIID:	2660854	Length:	1614	Species:	Mus musculus

Alignment Length:	947	Identity:	178/947 - (18%)
Similarity:	314/947 - (33%)	Gaps:	350/947 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   297 DVSILYADVVNYTHLTTTLT--------VEMLVKVLHDLYGRFDLAAYRYKV-----QRIKFLGD 348
            |..:::.|:..:|.:|...:        .|.||::|:     :.::|...||     ..:||.||
Mouse    40 DGVLMFVDISGFTAMTEKFSTAMYMDRGAEQLVEILN-----YYISAIVEKVLIFGGDILKFAGD 99

  Fly   349 CYYCVAGLSDPDPDHANN--CVILGLSM-INHIMEVRDI-HGLDINMRIGVHSGNLFAGVIG-EA 408
               .:..|...:.....|  .|::..|: |:.:.|.::. .||||.::||:.:|::...|.| |.
Mouse   100 ---ALLALWKVERKQLKNIITVVIKCSLEIHGLFEAKEAEEGLDIRVKIGLAAGHITMLVFGDET 161

  Fly   409 KLQFDIWGL---DVTIA-NVLESTGV---PGCVHISGATLNNLDVNRFDIEDGPEEARDHPLLKK 466
            :..|.:.|.   ||.:| |:.:...|   |.|..:       .|.:..:||..|::
Mouse   162 RNYFLVIGQAVDDVRLAQNMAQMNDVILSPNCWQL-------CDRSMIEIERIPDQ--------- 210

  Fly   467 YRIRSYIIRQDLHMDDEDSDEFLGDLHSISLCNMGAQPRISDSANQSLRALFHEELREEFRKMPV 531
                                                                        |.:.|
Mouse   211 ------------------------------------------------------------RAVKV 215

  Fly   532 SAFSPKRLLGICRFNTG-----KEVPAHQNLNI----CLTFTDPILE--------RAYLKQTD-- 577
            |...|........|.|.     ...|:..:.|.    |:..:||.||        ...|||.|
Mouse   216 SFLKPPPTFNFDEFFTKCMGFMDYYPSGDHKNFLRLACMLESDPELELSLQKYVMEIILKQIDDK 280

  Fly   578 YMYKYSIILSASVGCSLVYIELMDTQM---------ICSSCFVLPASVATIQCILALIAWYKKYC 633
            .:..|   ||.....::|::.||..:.         |.::|..:.:.:...:..:..:..:.|.|
Mouse   281 QLRGY---LSELRPVTIVFVNLMFKEQDKVEVIGSAIQAACVHITSVLKVFRGQINKVFMFDKGC 342

  Fly   634 WTRYGRNNVPHHYNGFSC-FIF---RIHDKILNSLPIRICIYLF-----------LMISSFFVMC 683
                          .|.| |.|   :..|:|.::|...:.|:.|           :.::|..|.|
Mouse   343 --------------SFLCVFGFPGEKAPDEITHALESAVDIFDFCSQVHKIRTVSIGVASGIVFC 393

  Fly   684 LIVMSCQREEF----EMAYIEERLFHYEQEAHICFHPWVTTNMLSLMICLTFT----------FA 734
            .||....|.|:    :...|..|:..|        :|.:.:       |.:.|          |.
Mouse   394 GIVGHTVRHEYTVIGQKVNIAARMMMY--------YPGIVS-------CDSVTYDGSNLPAYFFK 443

  Fly   735 HIPIMVKTAVAILETLAYLLLIFFQFDFVFHHSVTTNPYF-------KSEYAHALLICITF---- 788
            .:|..|...||                       ...|.:       |..:..|.|||..:
Mouse   444 ELPKKVMKGVA-----------------------DPGPVYQCLGLNEKVMFGMAYLICNRYEGYP 485

  Fly   789 LIMFVKERQIEFTNKVNFNWRVDLRKEENAASLTNHSIIIILNNILPSH-----IVDV-YLNSLA 847
            |:..|:|.....:...:|             .:||.|.:::... ||.:     :::: ||.|
Mouse   486 LLGRVREIDYFMSTMKDF-------------LMTNCSRVLMYEG-LPGYGKSQVLMEIEYLAS-- 534

  Fly   848 KHELYFENYRMVSVMFAMLINFEMDLRSLRVLNEIIAEFDTLLLFYKEYYT--VEKIKIVGCTYM 910
            :|    ||:|.|::.... |:|..:..::::|...:...|| ...|||..|  ..::|.:
Mouse   535 QH----ENHRAVAIALTK-ISFHQNFYTIQILMANVLGLDT-CKHYKERQTNLQNRVKTL----- 588

  Fly   911 AACGLD------------LNFAGSTSTNRKESIPPTEFNEEQSRRILFQQSNED-----LDEVVF 958
                ||            :.|..|...:|...|...:..|....:||.|...|:     :||..|
Mouse   589 ----LDEKFHCLLNDIFHVQFPVSREMSRMSKIRKQKQLEALFMKILAQTVREERIIFIIDEAQF 649

  Fly   959 V-MTSYA----------LDMMRTLAKSNE----AYQSIAGDRNITDGTIAIGISSGEVMAGIVGA 1008
            | .||:|          :.::.:||..:|    |..:|..:||.|..|:              |.
Mouse   650 VDGTSWAFIEKLIRSMPIFIVMSLAPFSEVPCAAANAIMKNRNTTYITL--------------GT 700

  Fly  1009 SQPHYDIWGNPVNMASRMESTGLPGHIHVTEETSEILQQFGITCSYRGMTFVKGRGKIPTY---- 1069
            .||.                 .:...:.|....|.|.::..   ||    .|:|...||.|
Mouse   701 MQPQ-----------------EIRDKVCVDLSVSSIPRELD---SY----LVEGSCGIPYYCEEL 741

  Fly  1070 LVGIDENLNFIPQKATRFPSHQERSTVISLQSTYTHA 1106
            |..:|.:...:.|:|     ..|:.|.::..:.:.|:
Mouse   742 LKNLDHHRVLLFQQA-----ETEQKTNVTWNNMFKHS 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454
		Nucleotidyl_cyc_III	290..459	CDD:325147	44/186 (24%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147	54/257 (21%)
Adcy10	NP_766617.2	CHD	40..214	CDD:143636	45/257 (18%)
		CHD	292..461	CDD:143636	35/220 (16%)
		COG3899	485..>959	CDD:226415	74/363 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900