Protein Alignment ACXE and Gucy2c

DIOPT Version :9

• Sequence 1: NP_652601.3
• Gene: ACXE / 53426
• FlyBaseID: FBgn0040506
• Length: 1123
• Species: Drosophila melanogaster
• Sequence 2: NP_037302.1
• Gene: Gucy2c / 25711
• RGDID: 2771
• Length: 1072
• Species: Rattus norvegicus
• Alignment Length: 974
• Identity: 202/974 - (20%)
• Similarity: 348/974 - (35%)
• Gaps: 286/974 - (29%)

  Fly   216 FY------RVMNDTVVRSSFLDRHQYIKEKIWLRNARLQEKQLLDSILPPQISLPLQKDIQGRIV 274
            ||      :|.:||||....|..:.|.::     :.|..|  .:|::|  .::||.:|.|
  Rat   254 FYNVKGDLKVADDTVVILVDLFSNHYFED-----DTRAPE--YMDNVL--VLTLPPEKFI----- 304

  Fly   275 MAKQGIHSWTAMERTMAIQIHPDVSILYAD-VVNYTHLTTTLTVEMLVKVLHDLYGRFDLAAYRY 338
             |...:......||:       |.|:.|.: .:.:.|:..|. :|....|....:.|    |:|
  Rat   305 -ANASVSGRFPSERS-------DFSLAYLEGTLLFGHMLQTF-LENGESVTTPKFAR----AFR- 355

  Fly   339 KVQRIKFLGDCYYCVAG--LSDPDPDHANNCVILGLSMINHIMEVRDIHGLDINMRIGVHSGNLF 401
               .:.|.|     :.|  ..|...|..|...:|.:|:.....:|...:....|..|.|.:...|
  Rat   356 ---NLTFQG-----LEGPVTLDDSGDIDNIMCLLYVSLDTRKYKVLMAYDTHKNQTIPVATSPNF 412

  Fly   402 AGVIGEAKLQFDIWGL--DVTIANVLESTGVPGCVHISGATLNNLDVNRFDIEDGPEEARDHPLL 464
              :....:|..|:.||  .:.:..|...||:. .|.:..|.|                     :|
  Rat   413 --IWKNHRLPNDVPGLGPQILMIAVFTLTGIV-VVLLLIALL---------------------VL 453

  Fly   465 KKYRIRSYIIRQD--LHMDDE-----------------DSDEFLGDLHSISLCNMGAQPRISDSA 510
            :||| |.:.:||.  .|:..|                 |.|.....:..:..|..       |..
  Rat   454 RKYR-RDHELRQKKWSHIPSENIFPLETNETNHVSLKIDDDRRRDTIQRVRQCKY-------DKK 510

  Fly   511 NQSLRAL------FHEELREEFRKMPVSAF-----------SPKRLLGI---CRFNTGKEVPAHQ 555
            ...|:.|      |.|:.:.|..|:..|.:           ...|:.|:   |...:.:||
  Rat   511 KVILKDLKHCDGNFSEKQKIELNKLLQSDYYNLTKFYGTVKLDTRIFGVVEYCERGSLREV---- 571

  Fly   556 NLNICLTFTDPILERAYLKQTDYMYKYSIILSASVGCSLVY---IE----------LMDTQMI-- 605
             ||..:::.|...       .|:.:|.|::...:.|.|.::   ||          ::|::|:
  Rat   572 -LNDTISYPDGTF-------MDWEFKISVLNDIAKGMSYLHSSKIEVHGRLKSTNCVVDSRMVVK 628

  Fly   606 -----CSSCFVLPASVATIQCILALIAWYKKYCWTRYGRNNVPHHYNGFSCFIFRIHDKILNSLP 665
                 |:|  :||.               ||..||      .|.|..  ...|.:..|
  Rat   629 ITDFGCNS--ILPP---------------KKDLWT------APEHLR--QATISQKGD------- 661

  Fly   666 IRICIYLFLMISSFFVM---CLIVMSCQREEFEMAYIEERLFHYEQEAHICFHPWVTTNMLSLMI 727
                :|.|.:|:...::   ....:|| |::.|..:..|..:..:......|........|.:.:
  Rat   662 ----VYSFSIIAQEIILRKETFYTLSC-RDQNEKIFRVENSYGTKPFRPDLFLETADEKELEVYL 721

  Fly   728 CLTFTFAHIPIMVKTAVAILETLAYLLLIFFQFDFVFHHSVTTNPYFKSEYAHALLICITFLIMF 792
            .:...:...|........|..|||.:..:|        |......|..:               .
  Rat   722 LVKSCWEEDPEKRPDFKKIESTLAKIFGLF--------HDQKNESYMDT---------------L 763

  Fly   793 VKERQIEFTNKVNF-NWRVDLRKEENAASLTNHSIIIILNNILPSHIVDVYLNSLAKHELYFENY 856
            ::..|:...|..:. ..|..|.|.|.  ...:|...::|..::...:.:   ..:.:.|||.|
  Rat   764 IRRLQLYSRNLEHLVEERTQLYKAER--DRADHLNFMLLPRLVVKSLKE---KGIVEPELYEE-- 821

  Fly   857 RMVSVMFAMLINF------EMDLRSLRVLNEIIAEFDTLLLFYKEYYTVEKIKIVGCTYMAACGL 915
              |::.|:.::.|      ...:..:.:||:|...||.::    :::.|.|::.:|..|:.|.||
  Rat   822 --VTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDQIV----DHHDVYKVETIGDAYVVASGL 880

  Fly   916 DLNFAGSTSTNRKESIPPTEFNEEQSRRILFQQSNEDLDEVVFVMTSYALDMMRTLAKSNEAYQS 980
            .:                     ....|.....|...||.:.| |.::.|:.:..|..
  Rat   881 PM---------------------RNGNRHAVDISKMALDILSF-MGTFELEHLPGLPV------- 916

  Fly   981 IAGDRNITDGTIAIGISSGEVMAGIVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTEETSEIL 1045
                      .|.||:.||...||:||...|.|.::|:.||.||||||||||..||::..|..||
  Rat   917 ----------WIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHMSSSTIAIL 971

  Fly  1046 QQFGITCSY----RGMTFVKGRGKIPTY-LVGIDENLNFIPQKATRFPSHQERSTVISLQSTYT 1104
            ::  ..|.:    ||.|::||||...|| |.|:.:....:|...|  ..:|:|     ||:.::
  Rat   972 RR--TDCQFLYEVRGETYLKGRGTETTYWLTGMKDQEYNLPTPPT--VENQQR-----LQTEFS 1026

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	17/61 (28%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	33/173 (19%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147	65/230 (28%)
Gucy2c	NP_037302.1	Periplasmic_Binding_Protein_Type_1	34..414	CDD:299141	43/197 (22%)
		PKc_like	479..749	CDD:304357	55/325 (17%)
		STYKc	501..744	CDD:214568	50/298 (17%)
		CYCc	787..978	CDD:214485	60/244 (25%)
		Guanylate_cyc	814..1001	CDD:278633	67/235 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900