Protein Alignment ACXE and Adcy6

DIOPT Version :10

• Sequence 1: NP_652601.3
• Gene: ACXE / 53426
• FlyBaseID: FBgn0040506
• Length: 1123
• Species: Drosophila melanogaster
• Sequence 2: NP_001257714.1
• Gene: Adcy6 / 25289
• RGDID: 2035
• Length: 1180
• Species: Rattus norvegicus
• Alignment Length: 1187
• Identity: 315/1187 - (26%)
• Similarity: 527/1187 - (44%)
• Gaps: 253/1187 - (21%)

  Fly     2 PRSLGNCQLNYSKERMWEPGYLKAKCAELRLESEFRLYRI-RLWKSYLLTFFMLHIFVTSVHCAL 65
            |||..:|         |.      :.|::....:||..:: ||::.|   ||.::    .....|
  Rat   124 PRSGPSC---------WH------RLAQVFQSKQFRSAKLERLYQRY---FFQMN----QSSLTL 166

  Fly    66 LLATIERRSIIYFDVALS---------------IGCALVLILVLSVNFCDEFIAKHTW---YMYA 112
            |:|.:    ::...|.|:               :.||.||.:||.| .|:    :|::   .|:.
  Rat   167 LMAVL----VLLMAVLLTFHAAPALPQPAYVALLTCASVLFVVLMV-VCN----RHSFRQDSMWV 222

  Fly   113 SSIFASLTLVFADLTESIYHTYAHSWILGTFYDTYIIYMIYMFLPIHFISGAVLLALLVSGLYIL 177
            .| :..|.::.|............|...|.:...:.:|:.|..|||. :..|||..|   ||..|
  Rat   223 VS-YVVLGILAAVQVGGALAANPRSPSAGLWCPVFFVYITYTLLPIR-MRAAVLSGL---GLSTL 282

  Fly   178 YFVI--FIAQGFAQFASALFSVGGMSVDIVHYLCLNLVGIFYRVMNDTVVRSSFLDRHQYIKEKI 240
            :.::  .:..|..      |....:..::|.:||.|.:|:......:...|.:|.:...||:.::
  Rat   283 HLILAWHLNNGDP------FLWKQLGANVVLFLCTNAIGVCTHYPAEVSQRQAFQETRGYIQARL 341

  Fly   241 WLRNARLQEKQLLDSILPPQISLPLQKDIQGRIVMAKQGIHSWTAMERTMAIQIHPDVSILYADV 305
            .|::...|:::||.|:||..:::.:::||..:    |:.:     |...:.||.|.:||||:||:
  Rat   342 HLQHENRQQERLLLSVLPQHVAMEMKEDINTK----KEDM-----MFHKIYIQKHDNVSILFADI 397

  Fly   306 VNYTHLTTTLTVEMLVKVLHDLYGRFDLAAYRYKVQRIKFLGDCYYCVAGLSDPDPDHANNCVIL 370
            ..:|.|.:..|.:.||..|::|:.|||..|......|||.||||||||:||.:...|||:.||.:
  Rat   398 EGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEM 462

  Fly   371 GLSMINHIMEVRDIHGLDINMRIGVHSGNLFAGVIGEAKLQFDIWGLDVTIANVLESTGVPGCVH 435
            |:.||..|..||::.|:::|||:|:|||.:..||:|..|.|||:|..|||:||.:|:.|..|.:|
  Rat   463 GVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIH 527

  Fly   436 ISGATLNNLDVNRFDIEDGPEEARDHPLLKKYRIRSYIIRQDLHMDDEDSDE--FLGDLHSISLC 498
            |:.|||..|: ..:::|.|....| :..||:..|.:::|   |....:..:|  .|..|......
  Rat   528 ITRATLQYLN-GDYEVEPGRGGER-NAYLKEQCIETFLI---LGASQKRKEEKAMLVKLQRTRAN 587

  Fly   499 NM-GAQPR--------------------ISDSANQ---SLRALFHEELREEFRKMPVSAFSPKRL 539
            :| |..||                    |.||:.:   :..||..|:..:||....:.|.|..:|
  Rat   588 SMEGLMPRWVPDRAFSRTKDSKAFRQMGIDDSSKENRGAQDALNPEDEVDEFLGRAIDARSIDQL 652

  Fly   540 L--GICRFNTGKEVPAHQNLNICLTFTDPILERAYLKQTDYMYKYSIILSASVGCSLVYIELMDT 602
            .  .:.||              .|||....||:.|.::.|..:      .|.|.|:|:
  Rat   653 RKDHVRRF--------------LLTFQREDLEKKYSRKVDPRF------GAYVACALL------- 690

  Fly   603 QMICSSCF----VLPAS---------------VATIQCILALIAWYKKYCWTRYGRNNVPHHYNG 648
             :.|..||    |.|.|               |..:.|.:.....:......|..|:.|....:.
  Rat   691 -VFCFICFIQFLVFPHSALILGIYAGIFLLLLVTVLICAVCSCGSFFPNALQRLSRSIVRSRVHS 754

  Fly   649 FSCFIFRIHDKILNSL---------PIRICIYLFLMISSFFVMCLIVMSCQREEFEMAY-IEERL 703
            .:..:|.:....::::         |:|.|....|.::.     ..|.:|...:...:. :|..|
  Rat   755 TAVGVFSVLLVFISAIANMFTCSHTPLRTCAARMLNLTP-----SDVTACHLRQLNYSLGLEAPL 814

  Fly   704 FHYEQEAHICFHPWVTTNMLSLMICLTFTFAHIPIMVKTAVAILETLAYLLL--------IFFQF 760
              .|..|..|..|......:.|.:..:..|.||..:.|..:..:....||||        ||..:
  Rat   815 --CEGTAPTCSFPEYFVGSVLLSLLASSVFLHISSIGKLVMTFVLGFIYLLLLLLGPPATIFDNY 877

  Fly   761 DFVF--HHSVTTNPYFKS-----------EYAHALLICITFLIMFVKERQIEFTNKVNFNWRVDL 812
            |.:.  |...::|..|..           :|...:::.:..|.:::..:|:|.|.:::|.|::..
  Rat   878 DLLLSVHGLASSNETFDGLDCPAVGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQA 942

  Fly   813 RKEENAASLTNHSIIIILNNILPSHIVDVYLNSLAKH----ELYFENYRMVSVMFAMLINF---- 869
            ..|:............:|:||||.   ||..:.||:.    |||:::...|:||||.:.||
  Rat   943 TGEKEEMEELQAYNRRLLHNILPK---DVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFY 1004

  Fly   870 -EMD-----LRSLRVLNEIIAEFDTLLLFYKEYYTVEKIKIVGCTYMAACGLDLNFAGSTSTNRK 928
             |::     :..||:||||||:||. ::..:.:..:||||.:|.|||||.||      :.||
  Rat  1005 VELEANNEGVECLRLLNEIIADFDE-IISEERFRQLEKIKTIGSTYMAASGL------NAST--- 1059

  Fly   929 ESIPPTEFNEEQSRRILFQQSNEDLDEV----VFVMTSYALDMMRTLAKSNEAYQSIAGDRNITD 989
                                    .|:|    :..:..||:.:|..:...||        .:..:
  Rat  1060 ------------------------YDQVGRSHITALADYAMRLMEQMKHINE--------HSFNN 1092

  Fly   990 GTIAIGISSGEVMAGIVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTEETSEILQQFGITCSY 1054
            ..:.||::.|.|:||::||.:|.||||||.||::|||:|||:|..|.||.:..::|...|.....
  Rat  1093 FQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLEC 1157

  Fly  1055 RGMTFVKGRGKIPTYLV 1071
            ||:..|||:|::.||.:
  Rat  1158 RGVVKVKGKGEMTTYFL 1174

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AcyC	65..453	CDD:441717	128/407 (31%)
		Nucleotidyl_cyc_III	290..459	CDD:448371	76/168 (45%)
		Nucleotidyl_cyc_III	851..1071	CDD:448371	78/233 (33%)
Adcy6	NP_001257714.1	AC_N	28..380	CDD:318454	67/306 (22%)
		Guanylate_cyc	382..566	CDD:425528	81/188 (43%)
		Adcy_cons_dom	594..681	CDD:461877	22/100 (22%)
		Guanylate_cyc	982..1176	CDD:425528	78/235 (33%)