DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXE and Npr1

DIOPT Version :9

Sequence 1:	NP_652601.3	Gene:	ACXE / 53426	FlyBaseID:	FBgn0040506	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	NP_036745.1	Gene:	Npr1 / 24603	RGDID:	3195	Length:	1057	Species:	Rattus norvegicus

Alignment Length:	1009	Identity:	211/1009 - (20%)
Similarity:	346/1009 - (34%)	Gaps:	296/1009 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 CLNLV-GIFYRV---MNDTVVRSSFL--DRHQYIKEKIWLRNARLQEKQL--------------- 252
            |..:| |::.||   :|.||....|:  |...|.|   .||..|.:.:.:
  Rat   192 CFFIVEGLYMRVRERLNITVNHQEFVEGDPDHYPK---LLRAVRRKGRVIYICSSPDAFRNLMLL 253

  Fly   253 -LDSILPPQISLPLQKDIQGRIVMAKQGIHSWTAMERTMAIQIHPDVSILYADVVNYTHLTTTLT 316
             |::.|..:..:....|:.|:.:.:.||:......||..........:...|.::.|........
  Rat   254 ALNAGLTGEDYVFFHLDVFGQSLKSAQGLVPQKPWERGDGQDRSARQAFQAAKIITYKEPDNPEY 318

  Fly   317 VEML--VKVLHDLYGRFDLAAYRYKVQRIKFLGDCYYCVAGLSDPDPDHANNCVILGLSMINHIM 379
            :|.|  :|:|.|       ..:.:.|:            .||.:..|...::.::|.:..:...:
  Rat   319 LEFLKQLKLLAD-------KKFNFTVE------------DGLKNIIPASFHDGLLLYVQAVTETL 364

  Fly   380 ----EVRDIHGLDINMRIGVHSGNLFAGVIGEAKL--------QFDIWGLDVTIANVLESTGVPG 432
                .|.|  |.:|..|:...|   |.||.|..|:        .|.:|.:|       ..||...
  Rat   365 AQGGTVTD--GENITQRMWNRS---FQGVTGYLKIDRNGDRDTDFSLWDMD-------PETGAFR 417

  Fly   433 CVHISGATLNNL-----------------DVNR--FDIEDGPEEARDH------------PLLKK 466
            .|.....|...|                 ||.:  ||.|| |...:||            ..|..
  Rat   418 VVLNYNGTSQELMAVSEHKLYWPLGYPPPDVPKCGFDNED-PACNQDHFSTLEVLALVGSLSLIS 481

  Fly   467 YRIRSYIIRQDLHMDDEDSDEF----LGDLHSIS----LCNMGAQPRISDSANQSLRALFHEELR 523
            :.|.|:.|.:.:.::.|...|.    ..||...|    |.:.|::..:|...:.....|..|...
  Rat   482 FLIVSFFIYRKMQLEKELVSELWRVRWEDLQPSSLERHLRSAGSRLTLSGRGSNYGSLLTTEGQF 546

  Fly   524 EEFRKMPVSAFSPKRLLGICRFNTG------------KEVPAHQN-------------LNIC-LT 562
            :.|.|   :|:....|:.:.|.|..            |.:...||             .||| ||
  Rat   547 QVFAK---TAYYKGNLVAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILT 608

  Fly   563 FTDP------ILERAYLKQTDYMYKYSIILSASVGCSLVYIELMDTQMIC-------SSCFVLPA 614
            ...|      |||...: ..|:|::||:......|...::     ...||       |:|.|...
  Rat   609 EYCPRGSLQDILENESI-TLDWMFRYSLTNDIVKGMLFLH-----NGAICSHGNLKSSNCVVDGR 667

  Fly   615 SVATIQCILALIAWYKKYCWTRYGRNNV--PHHYNGFSCFIFRI--HDKILN--SLPIRIC---- 669
            .|..|               |.||..:.  |....|.:.|..::  ..::|.  |.|.|..
  Rat   668 FVLKI---------------TDYGLESFRDPEPEQGHTLFAKKLWTAPELLRMASPPARGSQAGD 717

  Fly   670 IYLFLMISSFFVMCLIVMSCQREEFEMAYIEERLFHYEQEAHICFHPWVTTNMLSLMICLTFTFA 734
            :|.|.:|.....:...|...:..:.....|.||:...||..   |.|.:...            :
  Rat   718 VYSFGIILQEIALRSGVFYVEGLDLSPKEIIERVTRGEQPP---FRPSMDLQ------------S 767

  Fly   735 HIPIMVKTAVAILETLAYLLLIFFQFDFVFHHSVTTNPYFKSEYAHALLICITFLIMFVKE---- 795
            |           ||.|..|:          ......:|..:..:....|.    |..|.||
  Rat   768 H-----------LEELGQLM----------QRCWAEDPQERPPFQQIRLA----LRKFNKENSSN 807

  Fly   796 -------RQIEFTNKVNFNWRVDLRKEENAASL-TNHSIIIILNNILPSHIVDVYLNSLAKHE-L 851
                   |..::.|.:.     :|.:|...|.| .......:|..|||..:.:    .|.:.| :
  Rat   808 ILDNLLSRMEQYANNLE-----ELVEERTQAYLEEKRKAEALLYQILPHSVAE----QLKRGETV 863

  Fly   852 YFENYRMVSVMFAMLINF------EMDLRSLRVLNEIIAEFDTLLLFYKEYYTVEKIKIVGCTYM 910
            ..|.:..|::.|:.::.|      ...::.:.:||::...||.::    :.:.|.|::.:|..||
  Rat   864 QAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVI----DNFDVYKVETIGDAYM 924

  Fly   911 AACGLDLNFAGSTSTNRKESIPPTEFNEEQSRRILFQQSNEDLDEVVFVMTSYALDMMRTLAKSN 975
            ...||                 |....:..:|.             |..|....||.:|:....:
  Rat   925 VVSGL-----------------PVRNGQLHARE-------------VARMALALLDAVRSFRIRH 959

  Fly   976 EAYQSIAGDRNITDGTIAIGISSGEVMAGIVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTEE 1040
            ...:.:         .:.|||.:|.|.||:||...|.|.::|:.||.||||||.|....||::.|
  Rat   960 RPQEQL---------RLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSE 1015

  Fly  1041 TSEILQQF-GITCSYRGMTFVKGRGKIPTY-LVG 1072
            |..:|::| |.....||...:||:||:.|| |:|
  Rat  1016 TKAVLEEFDGFELELRGDVEMKGKGKVRTYWLLG 1049

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	18/84 (21%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	38/201 (19%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147	58/227 (26%)
Npr1	NP_036745.1	PBP1_NPR_A	32..439	CDD:107380	54/280 (19%)
		ANF_receptor	50..410	CDD:279440	48/244 (20%)
		PK_GC-A_B	530..803	CDD:270944	63/336 (19%)
		TyrKc	543..797	CDD:197581	59/317 (19%)
		HNOBA	<812..857	CDD:285003	10/53 (19%)
		CYCc	836..1025	CDD:214485	55/235 (23%)
		Guanylate_cyc	863..1049	CDD:278633	59/228 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900