Protein Alignment ACXE and Gucy2f

DIOPT Version :10

• Sequence 1: NP_652601.3
• Gene: ACXE / 53426
• FlyBaseID: FBgn0040506
• Length: 1123
• Species: Drosophila melanogaster
• Sequence 2: NP_001007577.1
• Gene: Gucy2f / 245650
• MGIID: 105119
• Length: 1108
• Species: Mus musculus
• Alignment Length: 1236
• Identity: 249/1236 - (20%)
• Similarity: 423/1236 - (34%)
• Gaps: 391/1236 - (31%)

  Fly    46 SYLLTFFMLHIFVTSVH---------CALLLATIERRSIIYFDVAL--SIGCALVLILVLSVNFC 99
            |.||::|.:...::..|         |..|||.:   .::.:..||  .||       |:....|
Mouse     9 SRLLSWFAISSRLSGQHGLPSSKFLRCLCLLALL---PLLRWGQALPYKIG-------VIGPWTC 63

  Fly   100 DEFIAKHTWYMYASSIFASLTLVFADLTESIYHTYAHSWILGTFYDTYIIYMIYMFLPIHFISGA 164
            |.|.:|     ....:.|:|.:......::...:|:..::: ...|......:..|:. |
Mouse    64 DPFFSK-----ALPEVAAALAIERISRDKTFDRSYSFEYVI-LNEDCQTSKALASFIS-H----- 116

  Fly   165 VLLALLVSGLYILYFVIFIAQGFAQFASALFSVGGMSVD--IVHYLCLN-------LVGIFYRVM 220
               ..:.||     ||.....||.:.||.|    |.|.|  |..:.|:|       ....|.|.:
Mouse   117 ---QQMASG-----FVGPANPGFCEAASLL----GTSWDKGIFSWACVNHELDNKHSFPTFSRTL 169

  Fly   221 NDTV-----VRSSFLDRHQYI---KEKIWLRNARLQEKQLLDSILPPQISLPLQKDIQG------ 271
            ...:     |...|...|..:   .|.||:..|......|....||..:.|...:|.|.
Mouse   170 PSPIRVLVTVMKYFQWAHAGVISSDEDIWMHTANRVSSALRSQGLPVGVVLTSGRDSQSIQKALQ 234

  Fly   272 ------RIVMAKQGIHSWTAM----ERTMAIQIHPDVS-------------ILYADVVNYTH--- 310
                  ||.:....:||  |:    .:|..:::..|:.             :||:  :.|.|
Mouse   235 QIRQADRIRIIIMCMHS--ALIGGETQTHFLELAHDLKMTDGTYVFVPYDVLLYS--LPYKHSPY 295

  Fly   311 --------------LTTTLTVEMLVKVLHDLYGRFDLAAYRYKV-------QRIKFLGDCY---Y 351
                          ...|:|||...|..::.|..   ||.|.::       |.....|..|   |
Mouse   296 QVLRNNPKLREAYDAVLTITVESHEKTFYEAYAE---AAARGEIPEKPDSNQVSPLFGTIYNSIY 357

  Fly   352 CVA----------GLSDPDP--DHANNCVILGLSMI-------NHIME--VRDIHGLDINMRIGV 395
            .:|          |.:....  .|:.|....|.:.:       |.|.|  :.|.:|.:..:| |.
Mouse   358 FIAQAMNNAMKKNGRASAASLVQHSRNMQFYGFNQLIKTDSNGNGISEYVILDTNGKEWELR-GT 421

  Fly   396 HSGNL-------------FAG---VIGEAKLQFDIW---------GLDVTIANVLESTGVPGCVH 435
            ::.::             |.|   ...:||    .|         |:|..:|.::....:...:.
Mouse   422 YTVDMETELLRFRGTPIHFPGGRPTSADAK----CWFAERKICQGGIDPALAMMVCFALLIALLS 482

  Fly   436 ISG-ATLNNLDVNRFDIEDGPEEARDHPLLKKYRIRSYIIRQDL-----HMDDEDSDEFLGDLHS 494
            |:| |......:|:..:..||.             |..:..:|:     |...:...........
Mouse   483 INGFAYFIRRRINKIQLIKGPN-------------RILLTLEDVTFINPHFGSKRGSRASVSFQI 534

  Fly   495 ISLCNMGAQPRISDSANQSLRALFHEE---LREE----FRKMPVSAFSPKRLLGICR---FNTGK 549
            ||....|..||:|.|:.....|.:...   :.|.    .:|.|...|...:.:....   |...|
Mouse   535 ISEVQSGRSPRLSFSSGSLTPATYENSNIAIYEGDWVWLKKFPPGDFGDIKSIKSSASDVFEMMK 599

  Fly   550 EVPAHQNLNICLTF------------------TDPILERAYLKQTDYMYKYSIILSASVGCS-LV 595
            :: .|:|:|..|.|                  .:.||....:| .|:|:|.|::|....|.. |.
Mouse   600 DL-RHENVNPLLGFFYDSGMFAIVSEFCSRRSLEDILTNDDVK-LDWMFKSSLLLDLIKGMKYLH 662

  Fly   596 YIELMDTQMICSSCFVLPASVATIQCILALIAWYKKYCWTRYGRNNVPHHYNGFSCFIFRI---- 656
            :.|.:..::...:|.|....|..:               |.||.|::..        :.|:
Mouse   663 HREFIHGRLKSRNCVVDGRFVLKV---------------TDYGFNDILE--------MLRLSEEE 704

  Fly   657 --HDKILNSLP--------IRI-----CIYLFLMISSFFVM-----CLIVMSCQREEFEMAYIEE 701
              .:::|.:.|        ||:     .:|.|.:|....::     |::.:..:.       |.:
Mouse   705 PSEEELLWTAPELLRAPGGIRLGSFAGDVYSFAIIMQEVMVRGAPFCMMDLPAKE-------IID 762

  Fly   702 RLFHYEQEAHICFHPWVT-----TNMLSLM-ICLTFTFAHIPIMVKTAVAILETLAYLLLIFFQF 760
            ||    :.....:.|.|:     ...|.|| .|........|                     .|
Mouse   763 RL----KMPPPVYRPVVSPEYAPAECLQLMKQCWAEASEQRP---------------------TF 802

  Fly   761 DFVFHHSVTTNPYFKSEYAHALLICI----TFLIMFVKERQIEFTNKVNFNWRVDLRKEENAASL 821
            |.:|:...|.|...|:....::|..:    :.|...::||..|.        .::.:|.|.
Mouse   803 DEIFNQFKTFNKGKKTNIIDSMLRMLEQYSSNLEDLIRERTEEL--------EIEKQKTEK---- 855

  Fly   822 TNHSIIIILNNILPSHIVDVYLNSLAKH-ELYFENYRMVSVMFAMLINF------EMDLRSLRVL 879
                   :|..:||..:.:    ||.|. .:..|.:.:|::.|:.::.|      ...:..:.:|
Mouse   856 -------LLTQMLPLSVAE----SLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLL 909

  Fly   880 NEIIAEFDTLLLFYKEYYTVEKIKIVGCTYMAACGLDLNFAGSTSTNRKESIPPTEFNEEQSRRI 944
            |::...||.::..:..|    |::.:|..||.|.||                 |.......:..|
Mouse   910 NDLYTLFDAIIGSHDVY----KVETIGDAYMVASGL-----------------PKRNGSRHAAEI 953

  Fly   945 LFQQSNEDLDEVVFVMTSYALDMMRTLAKSNEAYQSIAGDRNITDGTIAIGISSGEVMAGIVGAS 1009
                :|..||    :::|.....||.:.:              ....|.||:.||.|:||:||.:
Mouse   954 ----ANMSLD----ILSSVGTFKMRHMPE--------------VPVRIRIGLHSGPVVAGVVGLT 996

  Fly  1010 QPHYDIWGNPVNMASRMESTGLPGHIHVTEETSEILQQF--GITCSYRGMTFVKGRGKIPTY-LV 1071
            .|.|.::|:.||.||||||||||..|||:..|..|||..  |.....||.|.:||:|...|: ||
Mouse   997 MPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQTLSEGYEVELRGRTELKGKGTEETFWLV 1061

  Fly  1072 G 1072
            |
Mouse  1062 G 1062

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AcyC	65..453	CDD:441717	96/509 (19%)
		Nucleotidyl_cyc_III	290..459	CDD:448371	44/255 (17%)
		Nucleotidyl_cyc_III	851..1071	CDD:448371	64/228 (28%)
Gucy2f	NP_001007577.1	PBP1_sensory_GC_DEF-like	54..435	CDD:380594	79/419 (19%)
		Protein Kinases, catalytic domain	545..815	CDD:473864	57/326 (17%)
		HNOBA	<824..869	CDD:462234	10/67 (15%)
		CYCc	848..1040	CDD:214485	65/249 (26%)