DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXE and Gucy1b2

DIOPT Version :9

Sequence 1:	NP_652601.3	Gene:	ACXE / 53426	FlyBaseID:	FBgn0040506	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	XP_011243363.2	Gene:	Gucy1b2 / 239134	MGIID:	2660873	Length:	829	Species:	Mus musculus

Alignment Length:	850	Identity:	168/850 - (19%)
Similarity:	277/850 - (32%)	Gaps:	351/850 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   444 LDVNRFDIEDGPEEARDHPLLKKYRIRSYIIRQDLHMDDEDSDEFLGDLHSISLC------NMGA 502
            |.|...|..||   ....||..::|.:    |..|....|...:||..|.|.|..      ..|.
Mouse    45 LKVKMSDTADG---VLYEPLRAEFRSK----RTHLQGSAEGRGQFLASLQSTSTAFQRFGKTPGV 102

  Fly   503 QPRISDSA--------NQSLRALFHEELREE-FRKMPVSAFSPKRLLGICRFNTGKEVPAHQNLN 558
            |.|..|:.        |..|::|..|:..|| :.|:..||                ||.     :
Mouse   103 QLRPGDTTLDTMYGFINTCLQSLVTEKFGEETWEKLKASA----------------EVQ-----D 146

  Fly   559 ICLTFTDPILERAYLKQTDYMYKYSIILSASVGCSLVYIELMDTQMICSSCFVLPASVATIQCIL 623
            :.:|:|                              ||.:.:..::|..:|..|..|   ::.||
Mouse   147 VFMTYT------------------------------VYDDTITVKLIQEACKALDVS---MEAIL 178

  Fly   624 ALIA-WYKKYCWTRYGRNNVPHHYNGFSCFIFRIHDKILNSLPIRI--------CIYLFLMIS-- 677
            .|.. ::.|:|           ..:|:        |::|.:|...:        .::.:|.:|
Mouse   179 KLFGEYFFKFC-----------KMSGY--------DRMLRTLGGNLTEFIENLDALHSYLALSYQ 224

  Fly   678 -----SFFV------------------MCLIV-----------------MSC--QREEFEMAYIE 700
                 ||.|                  :|.||                 ||.  ..||.|....:
Mouse   225 EMNAPSFRVEGGADGAMRLHYYSDRRGLCHIVPGIIEAVAKDFFDTDVAMSILDMNEEVERTGKK 289

  Fly   701 ER-LFHYEQEAH---------------------------------------IC------------ 713
            |. :|...|:|.                                       :|
Mouse   290 EHVVFLVVQKARRQIRGAKVNRPRDSENIQAKQESLQGTLLRKKERYLSIPVCPGEKSHSAVVRA 354

  Fly   714 ------------FHP------WVTTNMLSLMICLTFTFAHI----PIMVKTA-VAILETLAYLLL 755
                        |.|      |:...    :.|..|.| |:    .:.||.| |.|.:.:..:|.
Mouse   355 SVLLGKGPLGDTFQPVFPERLWIEEE----VFCNAFPF-HVVFDEALRVKQAGVNIQKYVPGILT 414

  Fly   756 IFFQFDFVF---HHSVTTN----------------------PYFKSEYAHAL---------LICI 786
            ..|..|..|   |..||.|                      ..:||:....|         |.|:
Mouse   415 QKFGLDEYFSIVHPQVTFNISSICKFINSQFILKTRREMMPEAWKSQPTLKLRGQMIWMESLKCM 479

  Fly   787 TFL-------IMFVKERQIEFTNKVNFNWRVDL------------------RKEENAASLTNHSI 826
            .|:       :..::|.::..::....:...||                  :|:|....|:||..
Mouse   480 VFMCSPKLRSLQELEESKMHLSDIAPHDTTRDLILLNQQRLAEMELSCQLEKKKEELRVLSNHLA 544

  Fly   827 I------IILNNILPSHIVDVYLNSLAK-HELYFENYRMVSVMFAMLINFE------MDLRSLRV 878
            |      .:|..:||.|:.    |.|.: .::....:...:::|:.::.|.      ..::.:.:
Mouse   545 IEKKKTETLLYAMLPEHVA----NQLKEGKKVAAGEFETCTILFSDVVTFTNICAACEPIQIVNM 605

  Fly   879 LNEIIAEFDTLLLFYKEYYTVEKIKIVGCTYMAACGLDLNFAGSTSTNRKESIPPTEFNEEQSRR 943
            ||.:.::||.|...:..|    |::.:|..||...|:.:               |.|.:.::
Mouse   606 LNSMYSKFDRLTNIHDVY----KVETIGDAYMVVGGVPV---------------PVESHAQR--- 648

  Fly   944 ILFQQSNEDLDEVVFVMTSYALDMMRTLAKSNEAYQSIAGDRNITDGTIAIGISSGEVMAGIVGA 1008
                            :.::||. ||..||  |....:.|:    ...|.:||.:|.|:||:||.
Mouse   649 ----------------VANFALG-MRISAK--EVMNPVTGE----PIQIRVGIHTGPVLAGVVGD 690

  Fly  1009 SQPHYDIWGNPVNMASRMESTGLPGHIHVTEETSEILQQFGITCSYRGMTFVKGRGKIPTYLVGI 1073
            ..|.|.::|:.||.||||||.|||..:|::......|:..|.....||...|||:||:.||.  :
Mouse   691 KMPRYCLFGDTVNTASRMESHGLPNKVHLSPTAHRALENKGFEIVTRGEIEVKGKGKMTTYF--L 753

  Fly  1074 DENLN 1078
            ..|||
Mouse   754 IRNLN 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454
		Nucleotidyl_cyc_III	290..459	CDD:325147	5/14 (36%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147	58/225 (26%)
Gucy1b2	XP_011243363.2	HNOB	115..276	CDD:400167	37/233 (16%)
		HNOBA	380..566	CDD:400168	37/194 (19%)
		Guanylate_cyc	572..754	CDD:306677	58/228 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810