DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXE and Adcy5

DIOPT Version :9

Sequence 1:	NP_652601.3	Gene:	ACXE / 53426	FlyBaseID:	FBgn0040506	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	NP_001012783.3	Gene:	Adcy5 / 224129	MGIID:	99673	Length:	1262	Species:	Mus musculus

Alignment Length:	1171	Identity:	317/1171 - (27%)
Similarity:	524/1171 - (44%)	Gaps:	223/1171 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SLGNC-----QLNYSKERMWEPGYLKAKCAELRLESEFRLYRIRLWKSYLLTFFMLHIFVTSVHC 63
            |||.|     |:..||           |....:||..::.|..||.:|.|.....:.:.|    |
Mouse   205 SLGACCLALLQIFRSK-----------KFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLV----C 254

  Fly    64 ALLLATIERRSIIYFDVALSIGCALVLILVLSVNFCDEFIAKHTWYMYASSIFASLTLVFADLTE 128
            .::||....|..:.......:..|:.:||:::| .|:. .|.|..:| ..:.:|.:.:|.|....
Mouse   255 LVMLAFHAARPPLQIAYLAVLAAAVGVILIMAV-LCNR-AAFHQDHM-GLACYALIAVVLAVQVV 316

  Fly   129 SIYHTYAHSWILGTFYDTYIIYMIYMFLPIHFISGAVLLALLVSGLYILYFVIFIAQGFAQFASA 193
            .:......|...|.::..:.||.||..||:. :..|||..:|:|.|:       :|......:..
Mouse   317 GLLLPQPRSASEGIWWTVFFIYTIYTLLPVR-MRAAVLSGVLLSALH-------LAISLHTNSQD 373

  Fly   194 LFSVGGMSVDIVHYLCLNLVGIFYRVMNDTVVRSSFLDRHQYIKEKIWLRNARLQEKQLLDSILP 258
            .|.:..:..:::.:.|.|:||:......:...|.:|.:..:.|:.::..:....|:::||.|:||
Mouse   374 QFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLP 438

  Fly   259 PQISLPLQKDIQGRIVMAKQGIHSWTAMERTMAIQIHPDVSILYADVVNYTHLTTTLTVEMLVKV 323
            ..:::.::.||.     |||.    ..|...:.||.|.:||||:||:..:|.|.:..|.:.||..
Mouse   439 RHVAMEMKADIN-----AKQE----DMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMT 494

  Fly   324 LHDLYGRFDLAAYRYKVQRIKFLGDCYYCVAGLSDPDPDHANNCVILGLSMINHIMEVRDIHGLD 388
            |::|:.|||..|......|||.||||||||:||.:...|||:.||.:|:.||..|..||::.|::
Mouse   495 LNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVN 559

  Fly   389 INMRIGVHSGNLFAGVIGEAKLQFDIWGLDVTIANVLESTGVPGCVHISGATLNNLDVNRFDIED 453
            :|||:|:|||.:..||:|..|.|||:|..|||:||.:|:.|..|.:||:.||||.|: ..:::|.
Mouse   560 VNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLN-GDYEVEP 623

  Fly   454 GPEEARDHPLLKKYRIRSYIIRQDLHMDDEDS----------------------------DEFLG 490
            |....| :..||::.|.:::|........|:.                            :...|
Mouse   624 GCGGDR-NAYLKEHSIETFLILSCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGG 687

  Fly   491 DLHSISLCNMGAQPRISDSANQSLRALFHEELREEFRKMPVSAFSPKRLLG--ICRFNTGKEVPA 553
            :..|..:..||.:.....:|.:|...   |:..:||....:.|.|..||..  :.:|
Mouse   688 NQVSKEMKRMGFEDPKDKNAQESANP---EDEVDEFLGRAIDARSIDRLRSEHVRKF-------- 741

  Fly   554 HQNLNICLTFTDPILERAYLKQTDYMYKYSIILSASVGC-SLVYIELMDTQM-----------IC 606
                  .|||.:|.||:.|.||.|..:      .|.|.| |||::.:...|:           ..
Mouse   742 ------LLTFREPDLEKKYSKQVDDRF------GAYVACASLVFLFICFVQITIVPHSLFMLSFY 794

  Fly   607 SSCFVLPASVATIQCILALIAWYKKYCWTRYGRNNVPHHYNGFSCFIFRIHDKILNSLPIRICIY 671
            .|||:|.|.|..:..|.|.:..:.....| ..|..|....|.....:|.|           ..::
Mouse   795 LSCFLLLALVVFVSVIYACVKLFPTPLQT-LSRKIVRSKKNSTLVGVFTI-----------TLVF 847

  Fly   672 LFLMISSFFVMCLIVMSCQREEFEM-------AYIEERLFHYE--QEAHICFHPWVTTN------ 721
            |...::.|......::.|..||..:       .::.|..|:|.  .|...|..|....|
Mouse   848 LSAFVNMFMCNSKNLVGCLAEEHNITVNQVNACHVMESAFNYSLGDEQGFCGSPQPNCNFPEYFT 912

  Fly   722 ---MLSLMICLTFTFAHIPIMVKTAVAILETLAYLLLIFFQFDFVFHHS---VTTNPYFKSEYA- 779
               :|||:.|  ..|..|..:.|..:.:.....|:|::......:|.::   ||.|....|...
Mouse   913 YSVLLSLLAC--SVFLQISCIGKLVLMLAIEFIYVLIVEVPGVTLFDNADLLVTANAIDFSNNGT 975

  Fly   780 -----HA----------LLICITFLIMFVKERQIEFTNKVNFNWRVDLRKEENAASLTNHSIIII 829
                 ||          ::|.:..|.:::..:|:|.|.:::|.|::...:|:............:
Mouse   976 SQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRL 1040

  Fly   830 LNNILPSHIVDVYLNSLAKH----ELYFENYRMVSVMFAMLINF-----EMD-----LRSLRVLN 880
            |:||||.   ||..:.||:.    |||:::...|:||||.:.||     |::     :..||:||
Mouse  1041 LHNILPK---DVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLN 1102

  Fly   881 EIIAEFDTLLLFYKEYYTVEKIKIVGCTYMAACGLD---LNFAGSTSTNRKESIPPTEFNEEQSR 942
            ||||:||. ::....:..:||||.:|.|||||.||:   .:.||.|.
Mouse  1103 EIIADFDE-IISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKAGKTH------------------ 1148

  Fly   943 RILFQQSNEDLDEVVFVMTSYALDMMRTLAKSNEAYQSIAGDRNITDGTIAIGISSGEVMAGIVG 1007
                          :..:..:|:.:|..:...||        .:..:..:.||::.|.|:||::|
Mouse  1149 --------------IKAIADFAMKLMDQMKYINE--------HSFNNFQMKIGLNIGPVVAGVIG 1191

  Fly  1008 ASQPHYDIWGNPVNMASRMESTGLPGHIHVTEETSEIL--QQFGITCSYRGMTFVKGRGKIPTYL 1070
            |.:|.||||||.||:||||:|||:|..|.||.:..::|  ..:.:.|  ||:..|||:|::.||.
Mouse  1192 ARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLEC--RGVVKVKGKGEMMTYF 1254

  Fly  1071 V 1071
            :
Mouse  1255 L 1255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	54/240 (23%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	77/168 (46%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147	77/234 (33%)
Adcy5	NP_001012783.3	AC_N	1..459	CDD:292831	66/288 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..194
		CYCc	425..620	CDD:214485	87/204 (43%)
		Guanylate_cyc	461..622	CDD:278633	75/161 (47%)
		DUF1053	669..761	CDD:283888	24/108 (22%)
		CYCc	1037..1238	CDD:214485	78/244 (32%)
		Guanylate_cyc	1063..1257	CDD:278633	77/236 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910