DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXE and Adcy2

DIOPT Version :9

Sequence 1:	NP_652601.3	Gene:	ACXE / 53426	FlyBaseID:	FBgn0040506	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	NP_705762.2	Gene:	Adcy2 / 210044	MGIID:	99676	Length:	1095	Species:	Mus musculus

Alignment Length:	1196	Identity:	322/1196 - (26%)
Similarity:	541/1196 - (45%)	Gaps:	251/1196 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 MWEPGYLKAKCAELRLESEFR--------LYRIRLW--KSY--------LLTFFMLHIFVTSVHC 63
            ||:....:.:....|.|:...        |.|.|.|  :||        |:.|.:|   :....|
Mouse     1 MWQEAMRRRRYLRDRAEAAAAAAAGGGEGLQRSRDWLYESYYCMSQQHPLIVFLLL---IVMGAC 62

  Fly    64 ALLLATIERRSIIYFDVAL----------SIGCALVLILVLSVNFCDEFIAKHTWYMYASSIFAS 118
            ..|||       ::|.:.|          ::..||.:...:.:..|.|.:.|....:::..|:
Mouse    63 LALLA-------VFFALGLEVEDHVAFLITVPTALAIFFAIFILVCIESVFKKLLRVFSLVIW-- 118

  Fly   119 LTLVFADLTESIYHTYAHSWILGTFYDTYIIYMIYMFLPIHFISGAVLLALLVSGLYILYFVIFI 183
            :.||........:.....:|...:|: .:||:::|..||.: :..|::.::|.|..:.:...:::
Mouse   119 ICLVAMGYLFMCFGGTVSAWDQVSFF-LFIIFVVYTMLPFN-MRDAIIASVLTSSSHTIVLSVYL 181

  Fly   184 AQG-------FAQFASALFSVGGMSVDIVHYLCLNLVGIFYRVMNDTVVRSSFLDRHQYIKEKIW 241
            :..       |.|..:          :::.::|.||.|.:::.:.:..::.::.|....||.:|.
Mouse   182 SATPGAKEHLFWQILA----------NVIIFICGNLAGAYHKHLMELALQQTYRDTCNCIKSRIK 236

  Fly   242 LRNARLQEKQLLDSILPPQISLPLQKDIQGRIVMAKQGIHSWTAMERT-----MAIQIHPDVSIL 301
            |...:.|:::||.|:||..|::.::.:|..|:...|.|     .||.|     :.::.|.:||||
Mouse   237 LEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAG-----QMENTNNFHNLYVKRHTNVSIL 296

  Fly   302 YADVVNYTHLTTTLTVEMLVKVLHDLYGRFDLAAYRYKVQRIKFLGDCYYCVAGLSDPDPDHANN 366
            |||:|.:|.|.:..:...||.:|::|:|:||..|...:..|||.||||||||:||....|:||.|
Mouse   297 YADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKN 361

  Fly   367 CVILGLSMINHIMEVRDIHGLDINMRIGVHSGNLFAGVIGEAKLQFDIWGLDVTIANVLESTGVP 431
            ||.:||.|...|.:|||..|:|||||:||||||:..||||..|.|:|:|..|||:||.:|:.|||
Mouse   362 CVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVP 426

  Fly   432 GCVHISGATLNNLDVNRFDIEDGPEEARDHPLLKKYRIRSYII-------RQDLHMDDEDSDEFL 489
            |.||||..||.:|: ..:.:|:|..|.|| |.||::.:::|.:       |...|:        .
Mouse   427 GRVHISSVTLEHLN-GAYKVEEGDGEIRD-PYLKQHLVKTYFVINPKGERRSPQHL--------F 481

  Fly   490 GDLHSISLCNMGAQPRIS------------------DS--------------------ANQSLRA 516
            ...|::....|.|..|::                  ||                    .|::||.
Mouse   482 RPRHTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTLRT 546

  Fly   517 -----LFHEELREEFRKMPVSAFSPKRLLGICRFNTGKEVPAHQNL-NICLTFTDPILERAYLKQ 575
                 .|.|||.|            :.:..|...|..|:....::: .|.|.|.:..:|:.|...
Mouse   547 KSQKKRFEEELNE------------RMIQAIDGINAQKQWLKSEDIQRISLFFYNKNIEKEYRAT 599

  Fly   576 TDYMYKYSIILSASVGCSLVYIELM---DTQMI--------CSSCFVLPASVA--TIQC---ILA 624
            ....:||.:..:..:...:..::::   .|.::        .|..|:|....|  .:||   ..|
Mouse   600 ALPAFKYYVTCACLIFLCIFIVQILVLPKTSILGFSFGAAFLSLIFILFVCFAGQLLQCSKKASA 664

  Fly   625 LIAWYKKYC-------WTRYGRNNVPHHYNGFSCFIFRIHDKILNSLPIRICIYLFLMISSFFVM 682
            .:.|..|..       |.|            .|..|      :..::.:.:.::....:|:....
Mouse   665 SLLWLLKSSGIIANRPWPR------------ISLTI------VTTAIILTMAVFNMFFLSNSEET 711

  Fly   683 CLIVMSCQREEFEMAYIEERLFHYEQEAHICFHPW-VTTNMLSLMICLTFTFAHIPI-------- 738
            .|...:.......:...:..:.|   ..::.|.|: :.:.:|.|:.|..|...:..:
Mouse   712 TLPTANASNANVSVPDNQTAILH---ARNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVA 773

  Fly   739 MVKTAVAILETLAYLL----LIFFQFDFVFHHSVTTNPYFKSEYAHALLICITFLIMFVKERQIE 799
            :|...:.:|.|.|::|    .:.||...::....|..         ::.:.|.|:.:.|..||.|
Mouse   774 LVGYNIILLHTHAHVLDAYSQVLFQRPGIWKDLKTMG---------SVSLSIFFITLLVLGRQSE 829

  Fly   800 FTNKVNFNWRVDLRKEENAASLTNHSIIIILNNILPSHIVDVYL-NSLAKHELYFENYRMVSVMF 863
            :..:::|.|:...:||........:...::|.|:||:|:.:.:| .||...|||.::|..|.|||
Mouse   830 YYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMF 894

  Fly   864 AMLINF-----EMD-----LRSLRVLNEIIAEFDTLLLFYKEYYTVEKIKIVGCTYMAACGLDLN 918
            |.:.:|     |.|     |..||:||||||:||.||...| :..|||||.:|.|||||.||
Mouse   895 ASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPK-FSGVEKIKTIGSTYMAATGL--- 955

  Fly   919 FAGSTSTNRKESIPPTEFNEEQSRRILFQQSNEDLDEVVFVMTSYALDMMRTLAKSNEAYQSIAG 983
                      .::|..|..:|..|:.:.          :..|..:|..::..|...|:
Mouse   956 ----------SAVPSQEHAQEPERQYMH----------IGTMVEFAYALVGKLDAINK------- 993

  Fly   984 DRNITDGTIAIGISSGEVMAGIVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTEETSEILQQF 1048
             .:..|..:.:||:.|.|:||::||.:|.||||||.||:||||:|||:...|.||||||.|||..
Mouse   994 -HSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLILQTL 1057

  Fly  1049 GITCSYRGMTFVKGRGKIPTYLVGID 1074
            |.||:.||:..|||:|.:.||.|..:
Mouse  1058 GYTCTCRGIINVKGKGDLKTYFVNTE 1083

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	54/275 (20%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	85/168 (51%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147	92/229 (40%)
Adcy2	NP_705762.2	AC_N	<37..264	CDD:292831	47/250 (19%)
		CYCc	240..443	CDD:214485	96/208 (46%)
		Guanylate_cyc	285..469	CDD:278633	91/185 (49%)
		DUF1053	499..603	CDD:283888	18/115 (16%)
		CYCc	852..1060	CDD:214485	91/239 (38%)
		Guanylate_cyc	882..1081	CDD:278633	92/230 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.880