Protein Alignment ACXE and Adcy2

DIOPT Version :10

• Sequence 1: NP_652601.3
• Gene: ACXE / 53426
• FlyBaseID: FBgn0040506
• Length: 1123
• Species: Drosophila melanogaster
• Sequence 2: NP_705762.2
• Gene: Adcy2 / 210044
• MGIID: 99676
• Length: 1095
• Species: Mus musculus
• Alignment Length: 1196
• Identity: 322/1196 - (26%)
• Similarity: 541/1196 - (45%)
• Gaps: 251/1196 - (20%)

  Fly    17 MWEPGYLKAKCAELRLESEFR--------LYRIRLW--KSY--------LLTFFMLHIFVTSVHC 63
            ||:....:.:....|.|:...        |.|.|.|  :||        |:.|.:|   :....|
Mouse     1 MWQEAMRRRRYLRDRAEAAAAAAAGGGEGLQRSRDWLYESYYCMSQQHPLIVFLLL---IVMGAC 62

  Fly    64 ALLLATIERRSIIYFDVAL----------SIGCALVLILVLSVNFCDEFIAKHTWYMYASSIFAS 118
            ..|||       ::|.:.|          ::..||.:...:.:..|.|.:.|....:::..|:
Mouse    63 LALLA-------VFFALGLEVEDHVAFLITVPTALAIFFAIFILVCIESVFKKLLRVFSLVIW-- 118

  Fly   119 LTLVFADLTESIYHTYAHSWILGTFYDTYIIYMIYMFLPIHFISGAVLLALLVSGLYILYFVIFI 183
            :.||........:.....:|...:|: .:||:::|..||.: :..|::.::|.|..:.:...:::
Mouse   119 ICLVAMGYLFMCFGGTVSAWDQVSFF-LFIIFVVYTMLPFN-MRDAIIASVLTSSSHTIVLSVYL 181

  Fly   184 AQG-------FAQFASALFSVGGMSVDIVHYLCLNLVGIFYRVMNDTVVRSSFLDRHQYIKEKIW 241
            :..       |.|..:          :::.::|.||.|.:::.:.:..::.::.|....||.:|.
Mouse   182 SATPGAKEHLFWQILA----------NVIIFICGNLAGAYHKHLMELALQQTYRDTCNCIKSRIK 236

  Fly   242 LRNARLQEKQLLDSILPPQISLPLQKDIQGRIVMAKQGIHSWTAMERT-----MAIQIHPDVSIL 301
            |...:.|:::||.|:||..|::.::.:|..|:...|.|     .||.|     :.::.|.:||||
Mouse   237 LEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAG-----QMENTNNFHNLYVKRHTNVSIL 296

  Fly   302 YADVVNYTHLTTTLTVEMLVKVLHDLYGRFDLAAYRYKVQRIKFLGDCYYCVAGLSDPDPDHANN 366
            |||:|.:|.|.:..:...||.:|::|:|:||..|...:..|||.||||||||:||....|:||.|
Mouse   297 YADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKN 361

  Fly   367 CVILGLSMINHIMEVRDIHGLDINMRIGVHSGNLFAGVIGEAKLQFDIWGLDVTIANVLESTGVP 431
            ||.:||.|...|.:|||..|:|||||:||||||:..||||..|.|:|:|..|||:||.:|:.|||
Mouse   362 CVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVP 426

  Fly   432 GCVHISGATLNNLDVNRFDIEDGPEEARDHPLLKKYRIRSYII-------RQDLHMDDEDSDEFL 489
            |.||||..||.:|: ..:.:|:|..|.|| |.||::.:::|.:       |...|:        .
Mouse   427 GRVHISSVTLEHLN-GAYKVEEGDGEIRD-PYLKQHLVKTYFVINPKGERRSPQHL--------F 481

  Fly   490 GDLHSISLCNMGAQPRIS------------------DS--------------------ANQSLRA 516
            ...|::....|.|..|::                  ||                    .|::||.
Mouse   482 RPRHTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTLRT 546

  Fly   517 -----LFHEELREEFRKMPVSAFSPKRLLGICRFNTGKEVPAHQNL-NICLTFTDPILERAYLKQ 575
                 .|.|||.|            :.:..|...|..|:....::: .|.|.|.:..:|:.|...
Mouse   547 KSQKKRFEEELNE------------RMIQAIDGINAQKQWLKSEDIQRISLFFYNKNIEKEYRAT 599

  Fly   576 TDYMYKYSIILSASVGCSLVYIELM---DTQMI--------CSSCFVLPASVA--TIQC---ILA 624
            ....:||.:..:..:...:..::::   .|.::        .|..|:|....|  .:||   ..|
Mouse   600 ALPAFKYYVTCACLIFLCIFIVQILVLPKTSILGFSFGAAFLSLIFILFVCFAGQLLQCSKKASA 664

  Fly   625 LIAWYKKYC-------WTRYGRNNVPHHYNGFSCFIFRIHDKILNSLPIRICIYLFLMISSFFVM 682
            .:.|..|..       |.|            .|..|      :..::.:.:.::....:|:....
Mouse   665 SLLWLLKSSGIIANRPWPR------------ISLTI------VTTAIILTMAVFNMFFLSNSEET 711

  Fly   683 CLIVMSCQREEFEMAYIEERLFHYEQEAHICFHPW-VTTNMLSLMICLTFTFAHIPI-------- 738
            .|...:.......:...:..:.|   ..::.|.|: :.:.:|.|:.|..|...:..:
Mouse   712 TLPTANASNANVSVPDNQTAILH---ARNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVA 773

  Fly   739 MVKTAVAILETLAYLL----LIFFQFDFVFHHSVTTNPYFKSEYAHALLICITFLIMFVKERQIE 799
            :|...:.:|.|.|::|    .:.||...::....|..         ::.:.|.|:.:.|..||.|
Mouse   774 LVGYNIILLHTHAHVLDAYSQVLFQRPGIWKDLKTMG---------SVSLSIFFITLLVLGRQSE 829

  Fly   800 FTNKVNFNWRVDLRKEENAASLTNHSIIIILNNILPSHIVDVYL-NSLAKHELYFENYRMVSVMF 863
            :..:::|.|:...:||........:...::|.|:||:|:.:.:| .||...|||.::|..|.|||
Mouse   830 YYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMF 894

  Fly   864 AMLINF-----EMD-----LRSLRVLNEIIAEFDTLLLFYKEYYTVEKIKIVGCTYMAACGLDLN 918
            |.:.:|     |.|     |..||:||||||:||.||...| :..|||||.:|.|||||.||
Mouse   895 ASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPK-FSGVEKIKTIGSTYMAATGL--- 955

  Fly   919 FAGSTSTNRKESIPPTEFNEEQSRRILFQQSNEDLDEVVFVMTSYALDMMRTLAKSNEAYQSIAG 983
                      .::|..|..:|..|:.:.          :..|..:|..::..|...|:
Mouse   956 ----------SAVPSQEHAQEPERQYMH----------IGTMVEFAYALVGKLDAINK------- 993

  Fly   984 DRNITDGTIAIGISSGEVMAGIVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTEETSEILQQF 1048
             .:..|..:.:||:.|.|:||::||.:|.||||||.||:||||:|||:...|.||||||.|||..
Mouse   994 -HSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLILQTL 1057

  Fly  1049 GITCSYRGMTFVKGRGKIPTYLVGID 1074
            |.||:.||:..|||:|.:.||.|..:
Mouse  1058 GYTCTCRGIINVKGKGDLKTYFVNTE 1083

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AcyC	65..453	CDD:441717	130/409 (32%)
		Nucleotidyl_cyc_III	290..459	CDD:448371	85/168 (51%)
		Nucleotidyl_cyc_III	851..1071	CDD:448371	92/229 (40%)
Adcy2	NP_705762.2	AcyC	54..474	CDD:441717	141/450 (31%)
		Guanylate_cyc	285..469	CDD:425528	91/185 (49%)
		Adcy_cons_dom	499..604	CDD:461877	18/116 (16%)
		Guanylate_cyc	882..1081	CDD:425528	92/230 (40%)