DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXE and gcy-37

DIOPT Version :9

Sequence 1:	NP_652601.3	Gene:	ACXE / 53426	FlyBaseID:	FBgn0040506	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	NP_500171.2	Gene:	gcy-37 / 191658	WormBaseID:	WBGene00001557	Length:	708	Species:	Caenorhabditis elegans

Alignment Length:	292	Identity:	57/292 - (19%)
Similarity:	125/292 - (42%)	Gaps:	45/292 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   248 QEKQLLDSILPPQISLPLQKDIQGRIVMAKQGIHSWTAMERTMAIQIHPDVSILYADVVNYTHLT 312
            |..:||...:||.|:..|:                   ..:|:..|...|.|:::.|:.::..::
Worm   402 QTDRLLFEFVPPVIAEALR-------------------AAKTVPAQEFSDCSVIFTDIPDFFTIS 447

  Fly   313 TTLTVEMLVKVLHDLYGRFDLAAYRYKVQRIKFLGDCYYCVAGLSDPDPDHANNCVILGLSMINH 377
            ...:...::.|:.||:.|||....::|..::..|.|.|..|.|:.:.:..|..:.:.|.|.::..
Worm   448 VNCSPTEIITVVTDLFHRFDRIIEKHKGYKVLSLMDSYLIVGGVPNANQYHCEDSLNLALGLLFE 512

  Fly   378 IMEVRDIHGLD--INMRIGVHSGNLFAGVIGEAKLQFDIWGLDVTIANVLESTGVPGCVHISGAT 440
            ..:| .:..|:  :.:|||||.|.:.||::.:.|.:|.:.|..|.:...:.|...||.|.:|.|.
Worm   513 AKQV-VVPKLERSVRLRIGVHCGPVVAGIVSQQKPRFCVLGNTVNVTKSICSHSSPGKVLVSNAV 576

  Fly   441 LNNLDVNRFDIEDGPEEARDHPLLKKYRIRSYIIRQDLHMDDEDS---DEFLGDLHSISLCNMGA 502
                                ..::.|:....::...:.:::.:..   ..||......|:.::..
Worm   577 --------------------RTMVTKHLKSIFVFNANGYLELQSGKVLTHFLEKNEKCSVWDIVD 621

  Fly   503 QPRISDSANQSLRALFHEELREEFRKMPVSAF 534
            :.:.::.:....|.|..:...||:::..|:|:
Worm   622 RDKATNDSIDGYRELHSDNGTEEWQEATVAAY 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	7/23 (30%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	39/170 (23%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147
gcy-37	NP_500171.2	HNOB	3..165	CDD:285002
		HNOBA	223..419	CDD:285003	6/16 (38%)
		CYCc	400..577	CDD:214485	47/214 (22%)
		Nucleotidyl_cyc_III	425..609	CDD:299850	41/204 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810