Protein Alignment ACXE and gcy-34

DIOPT Version :10

• Sequence 1: NP_652601.3
• Gene: ACXE / 53426
• FlyBaseID: FBgn0040506
• Length: 1123
• Species: Drosophila melanogaster
• Sequence 2: NP_506319.1
• Gene: gcy-34 / 191656
• WormBaseID: WBGene00001554
• Length: 686
• Species: Caenorhabditis elegans
• Alignment Length: 907
• Identity: 172/907 - (18%)
• Similarity: 310/907 - (34%)
• Gaps: 308/907 - (33%)

  Fly   272 RIVMAKQGIHSWTAMERTMAIQIHPD--VSILYADVVNYTHLTTTLTVEMLVKVLHD----LYGR 330
            ::|:.|.|...|..:......:...:  |:..|:|...|..:.   :|.:::||..|    :||.
 Worm    11 QLVIRKYGEDVWLQVLERSGFENGKENIVNHYYSDTDTYVLVD---SVSIVLKVTKDQIWEMYGG 72

  Fly   331 F--------------------------DLAAYRYKVQRIKF----LGDCYYCVAGLSDPDPDHAN 365
            |                          :|.:..|.:..:.:    .|..:.|     :.:||
 Worm    73 FLITYSMEIGWDELVRSMSPNLKGFLDNLDSLHYFIDHVVYKANLRGPSFRC-----EENPD--- 129

  Fly   366 NCVILGLSMINHIMEVRDIHGLDINMRIGVHSGNLFAGVIGE-AKLQFDIWGLDVTIANVLESTG 429
                 |..|:::           ...|.|::  ::..||:.| |||.|:   ||:::.
 Worm   130 -----GTLMLHY-----------FTGRPGLY--HIVKGVVKEVAKLVFN---LDISLV------- 166

  Fly   430 VPGCVHISGATLNNLDVNRFDIEDGPEEARDHPLLKKYRIRSYIIRQDLHMDDEDSDEFLGDLHS 494
                  :.|.|..::.:|      ..|...:|.:        ::|: ::.....|||
 Worm   167 ------VQGRTQRSVHMN------NGERVEEHVI--------FLIK-NVEEPRRDSD-------- 202

  Fly   495 ISLCNMGAQPRISDSANQSLRALFHEELREEFRKMPVSAFSPKRLLGICRFNTGKEVPAHQNLNI 559
                      ..:.||..|:...|.|.:.:.. |:.:..||             :.:|.|
 Worm   203 ----------TSTTSALTSVEPDFGEIIDDNL-KVSLQDFS-------------RALPYH----- 238

  Fly   560 CLTFTDPILERAYLKQTDYMYKYSIILSASVGCSLVYIELMDTQMICSSCFVLPASVATIQCILA 624
                                                              |||..|...:||...
 Worm   239 --------------------------------------------------FVLDESCRLVQCGDE 253

  Fly   625 LIAWYKKYCWTRYGRNNVPHHYNGFSCFIFRIHDKILNSLPI---RICIYLFLMISSFFVMCLIV 686
            |.             |::|:........|.||.:.....:|:   .||.:    |::.||:.:..
 Worm   254 LY-------------NHIPNELLQPGTPILRIFEINRPQIPLDFENICNF----INAVFVLQVKT 301

  Fly   687 MSCQREEFEMAYIEERLFHYEQEAHICFHPWVTTNMLSLMICLTFTFAHIPIMVKTAVAILETLA 751
            ...:::.......|||    |||.. .....|.:|.|:       ...|:.:  |..:.:|.|..
 Worm   302 SPLRKKHMNAMTKEER----EQEVE-AMEEEVESNELT-------QGCHLKL--KGQMMMLSTKK 352

  Fly   752 YLLLIFFQFDFVFHHSVTTNPYFKSEYAHALL---ICITFLIMFVKERQIEFTNKVNF-NWRVDL 812
            :::.:             .:||..|  .:.|:   :.:|.:.:....|.:...|:... :..|:|
 Worm   353 HIIYL-------------CSPYVTS--INELMQFGMRLTAMPLHDATRDLILLNQQRLSDVEVNL 402

  Fly   813 RKEENAASL--TNHSIII-------ILNNILPSHIVDVYLNSLAKHELYFENYRMVSVMFAMLIN 868
            :.|.|...|  ..|.:.:       ||.::||..|....|:........:|    .:|||..|..
 Worm   403 QLEANNEQLETMTHELEVERQKTDSILKDMLPRKIAKQLLSGEHLEPCEYE----ATVMFCDLPA 463

  Fly   869 FEMDL------RSLRVLNEIIAEFDTLLLFYKEYYTVEKIKIVGCTYMAACGLDLNFAGSTSTNR 927
            |:..:      ..:::|||:..:.|.:::....|    |::.|..:||...|
 Worm   464 FQQIIPVCQPKNIVKLLNEVFFKLDRIVVLRGVY----KVETVSDSYMTVSG------------- 511

  Fly   928 KESIPPTEFNEEQSRRILFQQSNEDLDEVVFVMTSYALDMMRTLAKSNEAYQSIAGDRNITDGTI 992
               ||  ::..|.:..                |...||.||.      || :|:....|.|...:
 Worm   512 ---IP--DYTSEHAEN----------------MCHVALGMMW------EA-RSVMDPVNKTPFLL 548

  Fly   993 AIGISSGEVMAGIVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTEET-SEILQQFGITCSYRG 1056
            .||:.||.::||:||...|.|.::|..|.:||:|||.|:.|.|..:..| |:.::......|.||
 Worm   549 RIGLHSGTIIAGVVGTKMPRYCLFGETVTLASQMESLGVAGKIQCSSWTYSKAMETGRFEFSPRG 613

  Fly  1057 MTFVKGRGKIPTYLVGIDENLNFIPQKATRFPSHQERSTVISLQSTYTHAENNNSIASTSRH 1118
            ...|||||.:.||.:     :..:.:.......|:....|.|::. |...|.....|.|.:|
 Worm   614 RINVKGRGDVETYFL-----MRSLKKSIWEITDHERDVNVNSIEG-YEELEIFIENAQTVKH 669

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AcyC	65..453	CDD:441717	37/217 (17%)
		Nucleotidyl_cyc_III	290..459	CDD:448371	34/205 (17%)
		Nucleotidyl_cyc_III	851..1071	CDD:448371	61/226 (27%)
gcy-34	NP_506319.1	HNOB	3..167	CDD:462233	34/200 (17%)
		HNOBA	224..441	CDD:462234	54/331 (16%)
		CYCc	421..609	CDD:214485	57/236 (24%)