DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXE and gcy-21

DIOPT Version :9

Sequence 1:	NP_652601.3	Gene:	ACXE / 53426	FlyBaseID:	FBgn0040506	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	NP_001364740.1	Gene:	gcy-21 / 191651	WormBaseID:	WBGene00001546	Length:	1163	Species:	Caenorhabditis elegans

Alignment Length:	291	Identity:	81/291 - (27%)
Similarity:	125/291 - (42%)	Gaps:	71/291 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   829 ILNNILPSHIVD-VYLNSLAKHELYFENYRMVSVMFAMLINF-EMDLRS-----LRVLNEIIAEF 886
            :|..:||..:.| :.|.|....| .|||   .:|.|:....| ||...|     ::.||::...|
Worm   925 LLKMMLPEVVADSLKLGSNVSAE-SFEN---CTVFFSDCPGFVEMSATSKPIDIVQFLNDLYTVF 985

  Fly   887 DTLLLFYKEYYTVEKIKIVGCTYMAACGLDLNFAGSTSTNRKESIPPTEFNEEQSRRILFQQSNE 951
            |.::    :.:.|.|::.:...||.|.||              .:|               ..|.
Worm   986 DRII----DQFDVYKVETIADAYMVASGL--------------PVP---------------NGNH 1017

  Fly   952 DLDEVVFVMTSYALDMMRTLAKSNEAYQSIAGDRNITDGTI--AIGISSGEVMAGIVGASQPHYD 1014
            ...|:    .|..|    .|.|:.|:::.    |::.:..:  .||::||..:||:||...|.|.
Worm  1018 HAGEI----ASLGL----ALLKAVESFKI----RHLPNEKVRLRIGMNSGPCVAGVVGLKMPRYC 1070

  Fly  1015 IWGNPVNMASRMESTGLPGHIHVTEETSEILQQF-GITCSYRGMTFVKGRGKIPTYLVGIDENLN 1078
            ::|:.||.||||||.|:|..|:.:....|||.|. |.....||:..:||:||..||.|. .||.:
Worm  1071 LFGDTVNTASRMESNGIPLRINCSGTAKEILDQLGGYEIEERGIVEMKGKGKQMTYFVR-GENSD 1134

  Fly  1079 FIPQKATRFPSHQERSTVISL------QSTY 1103
            ...::..|     ||....||      :.||
Worm  1135 MRRERIIR-----ERVKFASLKKAQIQEKTY 1160

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454
		Nucleotidyl_cyc_III	290..459	CDD:325147
		Nucleotidyl_cyc_III	851..1071	CDD:325147	64/228 (28%)
gcy-21	NP_001364740.1	Periplasmic_Binding_Protein_type1	58..422	CDD:415822
		PK_GC	612..881	CDD:270894
		HNOBA	<890..938	CDD:400168	4/12 (33%)
		Guanylate_cyc	944..1130	CDD:306677	66/235 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810