Protein Alignment ACXE and gcy-19

DIOPT Version :9

• Sequence 1: NP_652601.3
• Gene: ACXE / 53426
• FlyBaseID: FBgn0040506
• Length: 1123
• Species: Drosophila melanogaster
• Sequence 2: NP_001348702.1
• Gene: gcy-19 / 191650
• WormBaseID: WBGene00001544
• Length: 1187
• Species: Caenorhabditis elegans
• Alignment Length: 1189
• Identity: 218/1189 - (18%)
• Similarity: 386/1189 - (32%)
• Gaps: 430/1189 - (36%)

  Fly   109 YMYASSIFA-SLTLVFA----------DLTESIYHTYAHSWILGTF---------YDTYIIYMIY 153
            |.|.::|.| ||:|.|:          |....:|...|..:.|...         |||:.:.::
 Worm   156 YPYLTNIMANSLSLGFSLVKLLEMMEWDRVALVYEESAQDYPLSVINDVETAINEYDTFAVNVV- 219

  Fly   154 MFLPIHFISGAVLLALLVSGLYILYFVIFIAQGFAQFASALFSVGGMSVDIVHYLCLNLVGIF-- 216
                       |..||....|           ..||:.|.|        :.:...|..:|.:|
 Worm   220 -----------VKQALPGGDL-----------NDAQYISVL--------NRIKLRCRIIVSVFQT 254

  Fly   217 ------YRVMNDTVVRSSFLDRHQYIKEKIWLR-------NARLQEKQL--LDSILPPQISLPLQ 266
                  |..|.|    ...:...:|:...:.||       :|.|.:.:|  |.|.|.|...:...
 Worm   255 APTRRRYLKMID----QQGMANEEYVHILLGLRSIGFGKQSAGLTKCELNCLSSGLAPFWDIAPD 315

  Fly   267 KDIQGRIVMAKQGIHSWTAMERTMAIQIHPDVSILYADVVNYTHLTT------------------ 313
            ..:..|:   ||      |..|.:.:.: ||...|..||.:..:|.|
 Worm   316 DGLNDRL---KQ------AATRMLVMDL-PDTMDLSTDVPDINYLNTFTMNCGAVVVNPPVSCAT 370

  Fly   314 -------TLTVEMLVKVLHDLYGRFDLAAYRYKVQRIKFLGDCYYCVAGLSDPDPDHANNCVILG 371
                   |.......:.|||::..:.||                  :..|.:.||.:.|
 Worm   371 PACINASTSPPSAFARSLHDVFYLYGLA------------------ITNLYNQDPAYLN------ 411

  Fly   372 LSMINHIMEVRDIHG-LDINMRIGVHSGNLFAGVIGEAKL-----------------QFD----- 413
                    ::..|:| |.:|          |||:.||..:                 ::|
 Worm   412 --------DIDKINGALQLN----------FAGLTGEVSINANNSRVPKLMLYALNDKYDQASFM 458

  Fly   414 ------IWGLDVTIANVLEST-----------GVPGC------------------VHISGATL-- 441
                  ..|..|::|...|::           .||.|                  |...|..|
 Worm   459 NLTYSLNGGASVSLAYTNEASLWYWYGGKRPLSVPVCGFAGTDCPQSFVDQYGALVFAIGGVLIF 523

  Fly   442 ---------------NNLDVNRFDIE--------DGPEEARDHPLLKKYRIRSYIIRQDLHMDDE 483
                           ..|:.:|.|.|        ..|.: ||...:.|..::|    ...::.|.
 Worm   524 AMLFVITCFFYVMRQKRLERDRIDAEWQIPLVKLQAPPK-RDKERMSKRSLQS----GPSNITDT 583

  Fly   484 DSDEFLGDLHSISLCNMGAQPRISDSANQS------------LRALFHEELREEFRKMPVSAFSP 536
            ....|.....:.|:..:..:|.:|.:...|            ||.|.||.: .:|..|.:.....
 Worm   584 SKMTFDNTFSNYSIFYLDKEPVLSTAHPASNLIRTDYDTFVRLRKLDHENV-NKFVGMSIDGPEY 647

  Fly   537 KRLLGICRFNTGKEVPAHQNLNICLTFTDPILERAYLKQTDYMYKYSIILSASVGCSLVYIELMD 601
            ..:..:|...:.:::....|.:|     ||            .:.:.:|...:.|...::...:.
 Worm   648 LAVWKLCMRGSLQDIIGQGNFSI-----DP------------FFMFCVIRDMAEGLKYLHNSFLH 695

  Fly   602 TQMICSSCFVLPASVATIQCILALIAWYKKYCWTRYGRNNVPHHYNGFSCFIFRIHDKILNS--L 664
            ......|..||...           :|..|.  |.:|...:.............:..:::..  |
 Worm   696 VHANLRSGTVLVNE-----------SWQAKL--TDFGLGTLAEEKKPMKRRQLWMAPEVIRGTLL 747

  Fly   665 PIRI----CIYLFLMISSFFVMCLIVMSCQREEFEMA----YIEERLFHYEQEAHICFHPWVTTN 721
            |.:|    .||...:|:|       .:..::|.:.||    .::|.::..::.......|.:..:
 Worm   748 PHQIEKSADIYSLAVIAS-------EVLTRKEAWNMAERKDTVDEIVYRIKKGGPNAPRPELDMD 805

  Fly   722 ML----SLMICLTFTFAHIPIMVKTAVAILETLAYLL-----LIFFQFDFVFH--HSVTTNPYFK 775
            .:    :|:|.:...::..|....:|..|...|..::     |:    |.||:  ...|||
 Worm   806 GVEINHNLLILIRDCWSEEPADRPSADVICNLLKNMMPKKGNLM----DHVFNILEDYTTN---- 862

  Fly   776 SEYAHALLICITFLIMFVKERQIEFTNKVNFNWRVDLRKEENAASLTNHSIIIILNNILPSHIVD 840
                         |.:.|::|..|.|            .|:..|.       ::|..:||..:.:
 Worm   863 -------------LEVEVEDRTKELT------------AEKKKAD-------VLLGRMLPKQVAE 895

  Fly   841 VYLNSLAKHELYFENYRMVSVMFAMLINFEM------DLRSLRVLNEIIAEFDTLLLFYKEYYTV 899
            ..........   |.:..|:|.|:.::.|..      ..:.:.:||::.:.||.::    |.:..
 Worm   896 RLKQGQTVEP---EGFDSVTVFFSDVVKFTQLAAKCSPFQVVNLLNDLYSNFDAII----EEHGC 953

  Fly   900 EKIKIVGCTYMAACGLDLNFAGSTSTNRKESIPPTEFNEEQSRRILFQQSNEDLDEVVFVMTSYA 964
            .|::.:|..|:...||                 |:            :..|..:.::|    ..:
 Worm   954 YKVESIGDGYLCVSGL-----------------PS------------KNGNAHIKQIV----ELS 985

  Fly   965 LDMMRTLAKS-------NEAYQSIAGDRNITDGTIAIGISSGEVMAGIVGASQPHYDIWGNPVNM 1022
            ||.| :..||       .|..:            :.||::||..:||:||.|.|.|.::|:.||.
 Worm   986 LDFM-SYCKSFKIPHLPREKVE------------LRIGVNSGPCVAGVVGLSMPRYCLFGDTVNT 1037

  Fly  1023 ASRMESTGLPGHIHVTEETSEIL-----QQFGITCSYRGMTFVKGRGKIPTYLV--------GID 1074
            ||||||.|...|||::..:..:|     .|:. |.| ||...:||:|.:.|:.|        |:.
 Worm  1038 ASRMESNGKASHIHLSAASYTLLMKHYPNQYN-TAS-RGDVIIKGKGVMETFWVFERNNQFMGVS 1100

  Fly  1075 ENLNF-IPQKATRFPSHQE 1092
            .|..: ..:|||...|..|
 Worm  1101 SNSGYQSDKKATNNGSSPE 1119

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	39/199 (20%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	42/276 (15%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147	58/237 (24%)
gcy-19	NP_001348702.1	PBP1_NPR_GC_like	45..467	CDD:107347	71/397 (18%)
		PKc_like	571..841	CDD:328722	46/311 (15%)
		CYCc	876..1065	CDD:214485	54/248 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900