DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXE and gcy-17

DIOPT Version :9

Sequence 1:	NP_652601.3	Gene:	ACXE / 53426	FlyBaseID:	FBgn0040506	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	NP_001293327.1	Gene:	gcy-17 / 191649	WormBaseID:	WBGene00001542	Length:	1088	Species:	Caenorhabditis elegans

Alignment Length:	287	Identity:	77/287 - (26%)
Similarity:	135/287 - (47%)	Gaps:	60/287 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 GFAQFASALFSVGGMSVD--IVHYL--C----------LNLVGIFYRVMNDTVVRSSFLDRHQY- 235
            ||.....:|.:...:.::  :||.:  |          ::.|....|.|||. .:.:.:| |.:
Worm   762 GFNAIRPSLLTDEALEINPALVHLIRDCWTEKPSERPPIDQVRSLLRGMNDG-KKGNLMD-HVFN 824

  Fly   236 --------IKEKIWLRNARLQEKQ-----LLDSILPPQISLPLQKDIQGRIVMAKQGIHSWTAME 287
                    ::|::..|...|.|:|     ||..:||..::..|           |.|
Worm   825 MLETYASTLEEEVNERTKELVEEQKKSDVLLYRMLPKTVAEKL-----------KAG-------- 870

  Fly   288 RTMAIQIHPD----VSILYADVVNYTHLTTTLTVEMLVKVLHDLYGRFDLAAYRYKVQRIKFLGD 348
                |.|.|:    |:|.::|||.:|.|.:..|...:|::|:|||..||....:..|.:::.:||
Worm   871 ----ISIEPETFELVTIFFSDVVQFTTLASKCTPLQVVQLLNDLYTIFDSIIEQNDVYKVETIGD 931

  Fly   349 CYYCVAGLSDPD-PDHANNCVILGLSMINHIMEVRDIH--GLDINMRIGVHSGNLFAGVIGEAKL 410
            .|.||:||...: .||..:...:.|:.::.:.|.|..|  ...||:|||::.|::.|||:|....
Worm   932 GYLCVSGLPHRNGHDHIKHIARMSLAFLSSLAEFRVAHMPSERINLRIGINCGSVVAGVVGLTMP 996

  Fly   411 QFDIWGLDVTIANVLESTGVPGCVHIS 437
            ::.::|..|..|:.:||.|.||.:|:|
Worm   997 RYCLFGDAVNTASRMESNGKPGRIHVS 1023

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	23/113 (20%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	52/155 (34%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147
gcy-17	NP_001293327.1	Periplasmic_Binding_Protein_Type_1	25..404	CDD:299141
		ANF_receptor	47..398	CDD:279440
		PKc_like	539..808	CDD:304357	7/45 (16%)
		Pkinase	567..803	CDD:278497	6/40 (15%)
		HNOBA	<824..867	CDD:285003	9/42 (21%)
		CYCc	846..1038	CDD:214485	61/201 (30%)
		Guanylate_cyc	873..1060	CDD:278633	51/151 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900