DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXE and gcy-15

DIOPT Version :9

Sequence 1:	NP_652601.3	Gene:	ACXE / 53426	FlyBaseID:	FBgn0040506	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	NP_001364713.1	Gene:	gcy-15 / 191648	WormBaseID:	WBGene00001541	Length:	1104	Species:	Caenorhabditis elegans

Alignment Length:	321	Identity:	87/321 - (27%)
Similarity:	137/321 - (42%)	Gaps:	75/321 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   799 EFTNKVNFNWRVDLRKEENAASLTNHSIIIILNNILPSHIVD-VYLNSLAKHELYFENYRMVSVM 862
            ::|:|:..:  :..|.||..|......  .:|..:||..:.| :.|.|....| .|||   .:|.
Worm   840 KYTDKLEKD--IAERNEELEAEKAKSE--ALLKMMLPEVVADSLKLGSNVSAE-SFEN---CTVF 896

  Fly   863 FAMLINF-EMDLRS-----LRVLNEIIAEFDTLLLFYKEYYTVEKIKIVGCTYMAACGLDLNFAG 921
            |:....| ||...|     ::.||::...||.::    :.:.|.|::.:...||.|.||
Worm   897 FSDCPGFVEMSATSKPIDIVQFLNDLYTVFDRII----DQFDVYKVETIADAYMVASGL------ 951

  Fly   922 STSTNRKESIPPTEFNEEQSRRILFQQSNEDLDEVVFVMTSYALDMMRTLAKSNEAYQSIAGDRN 986
                    .:|               ..|....|:    .|..|    .|.|:.|:::.    |:
Worm   952 --------PVP---------------NGNHHAGEI----ASLGL----ALLKAVESFKI----RH 981

  Fly   987 ITDGTI--AIGISSGEVMAGIVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTEETSEILQQF- 1048
            :.:..:  .||::||..:||:||...|.|.::|:.||.||||||.|:|..|:.:....|||.|.
Worm   982 LPNEKVRLRIGMNSGPCVAGVVGLKMPRYCLFGDTVNTASRMESNGIPLRINCSGTAKEILDQLG 1046

  Fly  1049 GITCSYRGMTFVKGRGKIPTYLVGIDENLNFIPQKATRFPSHQERSTVISL------QSTY 1103
            |.....||:..:||:||..||.|. .||.:...::..|     ||....||      :.||
Worm  1047 GYEIEERGIVEMKGKGKQMTYFVR-GENSDMRRERIIR-----ERVKFASLKKAQIQEKTY 1101

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454
		Nucleotidyl_cyc_III	290..459	CDD:325147
		Nucleotidyl_cyc_III	851..1071	CDD:325147	64/228 (28%)
gcy-15	NP_001364713.1	Periplasmic_Binding_Protein_type1	2..363	CDD:415822
		PK_GC	553..822	CDD:270894
		HNOBA	<831..879	CDD:400168	10/42 (24%)
		Guanylate_cyc	885..1071	CDD:306677	66/235 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900