DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXE and gcy-13

DIOPT Version :9

Sequence 1:	NP_652601.3	Gene:	ACXE / 53426	FlyBaseID:	FBgn0040506	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	NP_506097.3	Gene:	gcy-13 / 191646	WormBaseID:	WBGene00001539	Length:	1028	Species:	Caenorhabditis elegans

Alignment Length:	256	Identity:	65/256 - (25%)
Similarity:	121/256 - (47%)	Gaps:	48/256 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 SVDIVHYLCLNLVGIFYRVMN----------DTVVRSSFLDRH-QYIKEKIWLRNARLQEKQ--- 251
            ::|:|:.|..|        ||          |.|.  |.|::| ..:::::..|...|.|::
Worm   759 NIDMVNKLMKN--------MNSGRSGSANLMDHVF--SVLEKHASSLEDEVQERMKELVEEKKKS 813

  Fly   252 --LLDSILPPQISLPLQKDIQGRIVMAKQGIHSWTAMERTMAIQIHPDVSILYADVVNYTHLTTT 314
              ||..:||.|::..|:                   :.:::..:....|:|.::|||.:|.|...
Worm   814 DILLYRMLPQQVAERLK-------------------LGQSVEPEAFESVTIFFSDVVGFTVLANK 859

  Fly   315 LTVEMLVKVLHDLYGRFDLAAYRYKVQRIKFLGDCYYCVAGLSDPD-PDHANNCVILGLSMINHI 378
            .|...:|.:|:|||..||....:....:::.:||.|..|:||...: .:|..|...:.|.:::.:
Worm   860 STPLQVVNLLNDLYTTFDAIIEKNDSYKVETIGDAYLVVSGLPRRNGTEHVANIANMSLELMDSL 924

  Fly   379 MEVRDIH--GLDINMRIGVHSGNLFAGVIGEAKLQFDIWGLDVTIANVLESTGVPGCVHIS 437
            ...:..|  ...:.:|||:|||:..|||:|....::.::|..|..|:.:||.|.||.:|:|
Worm   925 QAFKIPHLPQEKVQIRIGMHSGSCVAGVVGLTMPRYCLFGDTVNTASRMESNGKPGFIHLS 985

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	20/86 (23%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	45/151 (30%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147
gcy-13	NP_506097.3	PBP1_NPR_GC_like	3..397	CDD:107347
		ANF_receptor	13..368	CDD:279440
		PKc_like	548..770	CDD:304357	4/18 (22%)
		HNOBA	<797..829	CDD:285003	8/31 (26%)
		CYCc	808..1000	CDD:214485	52/197 (26%)
		Guanylate_cyc	835..1022	CDD:278633	45/151 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810