DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXE and gcy-4

DIOPT Version :9

Sequence 1:	NP_652601.3	Gene:	ACXE / 53426	FlyBaseID:	FBgn0040506	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	NP_496218.2	Gene:	gcy-4 / 191642	WormBaseID:	WBGene00001531	Length:	1136	Species:	Caenorhabditis elegans

Alignment Length:	906	Identity:	169/906 - (18%)
Similarity:	311/906 - (34%)	Gaps:	326/906 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   377 HIMEVRDIHGLDINMRIGVHS------GNL----------FAGVIGEAKLQ--------FDIWGL 417
            |:.:|..::|:.::   .::|      |||          |.|:.||.||.        :.::||
Worm   361 HLFDVFYMYGMAVS---SLNSTDPNVYGNLSLLIPKFTTAFEGMTGEVKLNEDLARKPLYQVYGL 422

  Fly   418 DVTIANVLESTGVPGCVHISGATLNNLDVN-RFDIEDGPEEARDH-------------------- 461
            :.....:       ..:.||   |.|..|| .|:..||..|....
Worm   423 NSEYDQI-------SLIDIS---LINDTVNVVFNYADGNTEVWHFWGGTRPPDTPVCGFLGKSCP 477

  Fly   462 -PLLKKYR------------------------IRSYIIRQD-LHMDDEDSDEFLGDLHSISL--- 497
             |:.::||                        ||:..:.|. ||.:        ..:|:|.|
Worm   478 LPIFEQYRALVIVAIAVTILILLAIIICMSSKIRNRRVEQSRLHSE--------WQIHAIKLRLP 534

  Fly   498 ----CNMGAQPRISDSAN--QSLRALFHEELREEFRKMPVSAFSPKRLLGICRFNTGKEVPA--- 553
                .:..:|...::||:  ::..:...:.:..||::.....:....|:    ..|..:|..
Worm   535 MHRRASKSSQESETESASETENFTSKSGDTMTSEFKETYTIQYLENDLV----LTTAHQVQELSQ 595

  Fly   554 -------------HQNLN-----------------ICL--TFTDPILERAYLKQTDYMYKYSIIL 586
                         |:|||                 :|.  :..|.|.:.::  ..||.:.:.:|.
Worm   596 AEMMKFVKLRKLDHENLNKFIGLSIDGSRFVSVWKMCSRGSLQDIISKGSF--SMDYFFMFCMIR 658

  Fly   587 SASVGCSLVYIELM--DTQMICSSCFVLPASVATIQCILALIAWYKKYCWTRYG------RNNVP 643
            ..:.|...::...:  ...:..::|.|..             :|..|.  ..:|      ....|
Worm   659 DIAEGLHYIHKSFLRHHGNLRSATCLVND-------------SWQVKL--ADFGLQFLQDEEEKP 708

  Fly   644 HHYNGFSCFIFRIHDKILNSLPIR-----ICIYLFLMISSFFVMCLIVMSCQREEFEMAY----I 699
            ...|    .::...:.|..||.|.     ..||.|.:::|..:       .:||.::::.    .
Worm   709 FKKN----MLWAAPEVIRGSLSIEQMDSSADIYSFAIVASEIL-------TKREAWDLSRRKEGY 762

  Fly   700 EERLFHYEQEAHICFHPWVTTNMLSLMICLTFTFAHIPIMV-KTAVAILE-----------TLAY 752
            ||..:..::.......|.:                ||.|.| :|.:|:::           :...
Worm   763 EEIKYAVKKGGQFVLRPDL----------------HIDIEVNQTLLALVKDCWCENPEERPSAEN 811

  Fly   753 LLLIFFQ---------FDFVFHHSVTTNPYFKSEYAHALLICITFLIMFVKERQIEFTNKVNFNW 808
            :..:.|.         .|.||.        ...||..:|.:       .|.||..|.|
Worm   812 VCKVLFDMTPNTEDNLMDHVFS--------MLEEYTSSLEV-------EVGERTKELT------- 854

  Fly   809 RVDLRKEENAASLTNHSIIIILNNILPSHIVDVYLNSLAKHELYFENYRMVSVMFAMLINFEMDL 873
               |.|:::.         |:|..:||..:.:   ...|...:..|::.:|:|.|:.|:.| .||
Worm   855 ---LEKKKSD---------ILLGRMLPKQVAE---RLKAGQAVEPESFDLVTVFFSDLVKF-TDL 903

  Fly   874 RS-------LRVLNEIIAEFDTLLLFYKEYYTVEKIKIVGCTYMAACGLDLNFAGSTSTNRKESI 931
            .|       :.:||::.:.||:::    |.:.|.|::.:|..::...||
Worm   904 ASKCSPFQVVNLLNDVFSNFDSII----EKHDVYKVESIGDGFLCVSGL---------------- 948

  Fly   932 PPTEFNEEQSRRILFQQSNEDLDEVVFVMTSYALDMMRTLAKSNEAYQSIAGDRNITDGTIAIGI 996
             |.....|..|:|:             .|:...::..|.....:...:.:         .:.:||
Worm   949 -PNRNGMEHIRQIV-------------GMSLCFMEFCRNFRIPHLPRERV---------ELRVGI 990

  Fly   997 SSGEVMAGIVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTEETSEIL---QQFGITCSYRGMT 1058
            :||..:||:||.|.|.|.::|:.||.||||||.|.|..||::|....:|   ..:....:.||..
Worm   991 NSGPCVAGVVGLSMPRYCLFGDTVNTASRMESNGKPSMIHMSEAAHSLLVNNYPYQFETNSRGEV 1055

  Fly  1059 FVKGRGKIPTY-LVGIDE----------NLNFIPQKATRFPSHQERSTVISLQSTYTHAEN 1108
            .:||:|.:.|| |:|...          .:|..|:|...|...:  .|..|.:|...:.||
Worm  1056 IIKGKGVMETYWLLGKMSLSNQSTPPITKVNHKPRKIASFTDSE--LTNYSFRSVSPYVEN 1114

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454
		Nucleotidyl_cyc_III	290..459	CDD:325147	25/106 (24%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147	58/230 (25%)
gcy-4	NP_496218.2	PBP1_NPR_GC_like	29..457	CDD:107347	25/108 (23%)
		ANF_receptor	49..423	CDD:279440	14/64 (22%)
		PKc_like	558..819	CDD:304357	43/308 (14%)
		HNOBA	<834..876	CDD:285003	14/70 (20%)
		CYCc	855..1047	CDD:214485	58/247 (23%)
		Guanylate_cyc	882..1070	CDD:278633	59/231 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900