Protein Alignment ACXE and gcy-3

DIOPT Version :9

• Sequence 1: NP_652601.3
• Gene: ACXE / 53426
• FlyBaseID: FBgn0040506
• Length: 1123
• Species: Drosophila melanogaster
• Sequence 2: NP_496037.1
• Gene: gcy-3 / 191641
• WormBaseID: WBGene00001530
• Length: 1140
• Species: Caenorhabditis elegans
• Alignment Length: 754
• Identity: 142/754 - (18%)
• Similarity: 275/754 - (36%)
• Gaps: 233/754 - (30%)

  Fly   404 VIGEAKLQFDIWGLDVTIANVLESTGVPGCVHISGATLNNLDVNRFDIEDGPEEARDHPLLKKYR 468
            :.||:|:                |||...|        .|.:|..|:        :|..|..|:
 Worm   563 ITGESKV----------------STGSEFC--------ENYEVKMFE--------KDMVLTMKF- 594

  Fly   469 IRSYIIRQDLHMDDEDSDEFLGDLHSISLCNMGAQPRISDSANQSLRALFHEELREEFRKMPVSA 533
                   |.::::..|.|:|:                       .||.|.||.|
 Worm   595 -------QYMNLNKADMDKFV-----------------------KLRKLDHENL----------- 618

  Fly   534 FSPKRLLGICRFNTGKEVPAHQNLNIC-LTFTDPILERAYLK--QTDYMYKYSIILSASVGCSLV 595
               .:.:|:       .:.:.|.:::. |.....:|:..|..  ..|:.:.|.||...:.|.|.:
 Worm   619 ---NKFIGL-------SIDSSQFISVTKLCSRGSLLDILYKGNFSMDFFFMYCIIKDVAEGMSYL 673

  Fly   596 YIELM--------DTQMICSSCFVLPASVATIQCILALIAWYKKYCWTRYGRNNVPHHYNGFSCF 652
            :...:        .|.::..|..|..|.....|.:..:....::..|.      .|....|
 Worm   674 HKSFLRLHGNLRSATCLVNDSWQVKLAEFGFDQLLEEITPTKRRLLWA------APEVLRG---- 728

  Fly   653 IFRIHDKILNSLPIRICIYLFLMISSFFVMCLIVMSCQREEFEM-----AYIEERLFHYEQEAHI 712
                 ...::.:.....::.|.:|:|..:       .::|.:::     .| :|.::..::....
 Worm   729 -----SLTVSQMDPSADVFSFAIIASEIL-------TRKEAWDLKERKEGY-DEIIYRVKKGGSF 780

  Fly   713 CFHPWVTTNM----LSLMICLTFTFAHIPIMVKTAVAILETLAYLL------LIFFQFDFVFHHS 767
            ...|.:.|::    .:|:..:...:|..|....||..|.|.|..|:      |:    |.||:
 Worm   781 PIRPDIITDVPDVNPTLIALVKDCWAEAPEDRPTAENICEQLRDLMPKTKSNLM----DHVFN-- 839

  Fly   768 VTTNPYFKSEYAHALLICITFLIMFVKERQIEFTNKVNFNWRVDLRKEENAASLTNHSIIIILNN 832
                  ...||...|.:       .|:||..|.|        ::.:|.:           ::|:.
 Worm   840 ------MLEEYTSTLEV-------EVEERTKELT--------LEKKKAD-----------LLLSR 872

  Fly   833 ILPSHIVDVYLNSLAKHELYFENYRMVSVMFAMLINFEM------DLRSLRVLNEIIAEFDTLLL 891
            :||..:.:   ...|...:..|.:..|:|.|:.::.|.:      ..:.:.:||::.:.|||::
 Worm   873 MLPKQVAE---RLKAGQTVEPEGFDSVTVFFSDVVKFTILASKCTPFQVVNLLNDLYSNFDTII- 933

  Fly   892 FYKEYYTVEKIKIVGCTYMAACGLDLNFAGSTSTNRKESIPPTE--FNEEQSRRILFQQSNEDLD 954
               |.:.|.|::.:|..|:...||                 ||.  ||.              :.
 Worm   934 ---EEHGVYKVESIGDGYLCVSGL-----------------PTRNGFNH--------------IK 964

  Fly   955 EVVFVMTSYALDMMRTLAKSNEAYQSIAGDRNITDGTIAIGISSGEVMAGIVGASQPHYDIWGNP 1019
            ::|.:...: :|..:.....:...:.:         .:.||::||..:||:||.|.|.|.::|:.
 Worm   965 QIVDMSLKF-MDYCKNFKIPHLPRERV---------ELRIGVNSGPCVAGVVGLSMPRYCLFGDT 1019

  Fly  1020 VNMASRMESTGLPGHIHVTEETSEILQQ---FGITCSYRGMTFVKGRGKIPTYLVGIDENLNFIP 1081
            ||.||||||.|.|..||:|.:...:|.:   .....:.||...:||:|.:.|:.| :..:.:..|
 Worm  1020 VNTASRMESNGKPSLIHLTSDAHLLLMKHFPHQYETNSRGEVIIKGKGVMETFWV-LGRSGDIEP 1083

  Fly  1082 QKATRF--PSHQERSTVISLQSTYTHAENNNSIASTSRH 1118
            ..:.|.  |..|||.||.:..:....:.:::....:|.|
 Worm  1084 SISNRSTPPVTQERFTVRAPDTPEARSVSSHGSRPSSNH 1122

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454
		Nucleotidyl_cyc_III	290..459	CDD:325147	10/54 (19%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147	55/230 (24%)
gcy-3	NP_496037.1	PBP1_NPR_GC_like	36..453	CDD:107347
		ANF_receptor	54..433	CDD:279440
		PKc_like	554..823	CDD:304357	57/366 (16%)
		HNOBA	<839..882	CDD:285003	12/79 (15%)
		CYCc	861..1051	CDD:214485	54/248 (22%)
		Guanylate_cyc	888..1076	CDD:278633	56/233 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810