Protein Alignment ACXE and gcy-1

DIOPT Version :9

• Sequence 1: NP_652601.3
• Gene: ACXE / 53426
• FlyBaseID: FBgn0040506
• Length: 1123
• Species: Drosophila melanogaster
• Sequence 2: NP_496039.1
• Gene: gcy-1 / 191639
• WormBaseID: WBGene00001528
• Length: 1137
• Species: Caenorhabditis elegans
• Alignment Length: 1281
• Identity: 218/1281 - (17%)
• Similarity: 413/1281 - (32%)
• Gaps: 448/1281 - (34%)

  Fly    15 ERMWEPGYLKAKCAELRLESEFRLYRIRLWKSYLLTFFMLHIFVTSVHCALLLATIERRSIIYF- 78
            ||:.|.|::|.                          |.....|....|.  |.::.|..:.:.
 Worm    63 ERLKEMGFVKD--------------------------FDFEYIVDYTECD--LGSVVRAGMEFIK 99

  Fly    79 ----DVALSIGCALVLILVLSVNFCDEFIAKH-----TWYMYASSIFASLTLVFADLT----ESI 130
                ||.:...||..|.|:       .|:|::     ..:.:.|....|..:.|..||    .|:
 Worm   100 THKVDVIIGPPCAQALRLM-------SFLAENYKKPVLGWGFVSDTDLSDVIRFPHLTTVIPNSL 157

  Fly   131 YHTYAHSWILGTFYDTYIIYMIYMFLPIHFISGAV--------------LLALLVSGLYI----- 176
            ...||.|.:|.||:...:. ::|.|..:.:.||.:              :..::.:.:|:
 Worm   158 MLGYAASKMLTTFHWNRVA-LLYYFSDVKYCSGVMNDIEATFNDPSTPNVNIVIKAEIYLNDNET 221

  Fly   177 -----------LYFVIFIAQGFAQFASALFSVG--GMSVDIVHYLCLNLVGI------------- 215
                       ...:::..|...:....|..:.  .|..|...::.|::..:
 Worm   222 TDNVFQTVKSRARIILWCTQTSVEKRDYLIKIATHDMIGDEYVHIMLSMRNVAFGTQTSLGKPTF 286

  Fly   216 ------------------FYRVMNDTVVRSSFLDRHQYIKEKIWLRNARLQEKQLLDSI-LPPQI 261
                              |.::......|...||.:..:.:|.:|   ...:|.::.:: .||..
 Worm   287 SQSGLTPIWESFTEGTDGFEKMAKQAATRMFVLDVNSEVADKKYL---EYMQKNIIKAVQSPPMN 348

  Fly   262 SLPLQKDIQGRIVMAKQGIHSWTAMERTMAIQIHPDVSILYADVVNYTHLTTTLTVEMLVKVLHD 326
            ...::.......:|.....|.:             ||..||...:.:|:.|...
 Worm   349 CSTVECMTANTTIMGGYARHLF-------------DVVYLYGIALTHTNSTDPA----------- 389

  Fly   327 LYGRFDLAAYRYKVQRIKFLGDCYYCVAGLSDPDPDHANNCVILGLSMINHI--------MEVRD 383
            :||..|:..:::..   .|.|                          |..|:        |.:..
 Worm   390 VYGDVDVLVHQFVT---SFQG--------------------------MTGHVVISPNLTRMPIFQ 425

  Fly   384 IHGLDINM------------RIGVHSGNLFAGVIGEAKLQFDIWG-------LDVTIANVLEST- 428
            ::||:.:.            .:.|.:..||....|.|     :|.       ||:.|...|..:
 Worm   426 LYGLNSDYDQVALVDFTYTNSVMVPNVTLFYKDEGGA-----VWSYYGHSRPLDIPICGFLGKSC 485

  Fly   429 -------------------------GVPGCV-HISGATLNNLDVN-------------------- 447
                                     .:.||: .|||.......:|
 Worm   486 PVSFWEQYKILIFVAIAVIVLMVLIMIIGCLCVISGKRAERARINAEWQVPFAKLIESEKQVRGK 550

  Fly   448 ---RFDIEDGPEEARDH-------PLLKKYRIRSY----IIR---QDLHMDDEDSDEFLGDLHSI 495
               |..::..|..:..|       ...:.|.:..|    ::.   |..|:...|.:.|:
 Worm   551 GASRRSLQSAPSISTGHSGVTTVSDFCENYTMMMYEKEMVLTAKYQYTHLTKADKERFV------ 609

  Fly   496 SLCNMGAQPRISDSANQSLRALFHEELREEFRKMPVSAFSPKRLLGICRFNTGKEVPAHQNLNIC 560
                             .:|.|.||.: ..|..:.:.:.....:..:|...:.:::.:..|.::
 Worm   610 -----------------KMRKLDHENI-NRFIGLSIDSAHFISVTKLCSRGSLQDILSRGNFSM- 655

  Fly   561 LTFTDPILERAYLKQTDYMYKYSIILSASVGCSLVYIELMDTQMICSSCFVLPASVATIQCILAL 625
                            ||.:.:.||...:.|  |.|:.        .:...|..::.:..| |..
 Worm   656 ----------------DYFFMFCIIRDVAKG--LEYLH--------KTFLRLHGNLRSATC-LVN 693

  Fly   626 IAWYKKYCWTRYGRNNVPHHYNGFSCFIFRIHDKIL-NSLPI-----RICIYLFLMISSFFVMCL 684
            .:|..|.  ..||.:|:..........:..:..::| .||.:     ...||.|.:|:|..:
 Worm   694 DSWQVKL--AEYGMDNLVEEQTPPKKRLLWVAPEVLRGSLSVSQMEPSADIYSFAIIASEIL--- 753

  Fly   685 IVMSCQREEFEM----AYIEERLFHYEQEAHICFHPWVTTNM----LSLMICLTFTFAHIPIMVK 741
                .::|.:::    ...||.:::.::.......|.:.|::    .:|:..:...:|.:|....
 Worm   754 ----TKKEAWDILDRKEDCEEIVYNVKKGGLFPIRPEIITDIHDVNPALIALVKDCWAEVPEDRP 814

  Fly   742 TAVAILETLAYLL------LIFFQFDFVFHHSVTTNPYFKSEYAHALLICITFLIMFVKERQIEF 800
            ||..|...:..|:      |:    |.||:        ...||...|            |.:||.
 Worm   815 TAENICSQMKGLVSKQKTNLM----DHVFN--------MLEEYTSTL------------EEEIEE 855

  Fly   801 TNKVNFNWRVDLRKEENAASLTNHSIIIILNNILPSHIVDVYLNSLAKHELYFENYRMVSVMFAM 865
            ..|       :|..|:..|.       |:|:.:||..:.:   ...|...:..|.:..|:|.|:.
 Worm   856 RTK-------ELTLEKKKAD-------ILLSRMLPKQVAE---RLKAGQTVEPEGFDSVTVFFSD 903

  Fly   866 LINFEM------DLRSLRVLNEIIAEFDTLLLFYKEYYTVEKIKIVGCTYMAACGLDLNFAGSTS 924
            ::.|.:      ..:::.:||::.:.|||::    |.:.|.|::.:|..|:...||
 Worm   904 VVKFTILASKCSPFQTVNLLNDLYSNFDTII----EQHGVYKVESIGDGYLCVSGL--------- 955

  Fly   925 TNRKESIPPTEFNEEQSRRILFQQSNEDLDEVVFVMTSYALDMMRTLAKSNEAYQSIAGDRNITD 989
                    ||.......::|:                ..:|..|......|..:   ....|:
 Worm   956 --------PTRNGYAHIKQIV----------------DMSLKFMEYCKSFNIPH---LPRENV-- 991

  Fly   990 GTIAIGISSGEVMAGIVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTEETSEIL-----QQFG 1049
             .:.||::||..:||:||.|.|.|.::|:.||.||||||.|.|..||:|.:...:|     .|:
 Worm   992 -ELRIGVNSGPCVAGVVGLSMPRYCLFGDTVNTASRMESNGKPSLIHLTNDAHSLLTTHYPNQY- 1054

  Fly  1050 ITCSYRGMTFVKGRGKIPTYLVGIDENLNFIPQKATRFPSHQERST 1095
             ..|.||...:||:|.:.|:.|    :..|...:.|...|...|||
 Worm  1055 -ETSSRGEVIIKGKGVMETFWV----HGRFGEMEPTELRSISNRST 1095

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	44/318 (14%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	34/245 (14%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147	58/230 (25%)
gcy-1	NP_496039.1	PBP1_NPR_GC_like	35..449	CDD:107347	67/477 (14%)
		ANF_receptor	53..432	CDD:279440	67/460 (15%)
		PKc_like	555..821	CDD:304357	49/326 (15%)
		HNOBA	<840..883	CDD:285003	14/79 (18%)
		CYCc	862..1051	CDD:214485	57/241 (24%)
		Guanylate_cyc	889..1077	CDD:278633	59/236 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900