DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXE and gcy-11

DIOPT Version :9

Sequence 1:	NP_652601.3	Gene:	ACXE / 53426	FlyBaseID:	FBgn0040506	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	NP_001359843.1	Gene:	gcy-11 / 181745	WormBaseID:	WBGene00001537	Length:	1168	Species:	Caenorhabditis elegans

Alignment Length:	301	Identity:	79/301 - (26%)
Similarity:	136/301 - (45%)	Gaps:	58/301 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 SFLDRHQ-----YIKEKI-WLRNARLQEKQLLDSILPPQISLPLQKDIQGRIVMAKQGIHSWTAM 286
            :.|||::     .|||:. .|.:.|.:.:.||..:||..::..|:   .|:.|.|
Worm   901 NLLDRYRNNLEDVIKERTEQLEDERKRNESLLLQLLPKSVANSLK---NGQPVDA---------- 952

  Fly   287 ERTMAIQIHPDVSILYADVVNYTHLTTTLTVEMLVKVLHDLYGRFDLAAYRYKVQRIKFLGDCYY 351
                  :.:..|||.::|:|.:|.|::..|...:|.:|::||..||....::...:::.:||.|.
Worm   953 ------EFYDSVSIYFSDIVGFTALSSKSTPLQVVNMLNNLYTNFDTIIDKFDCYKVETIGDAYM 1011

  Fly   352 CVAGLSDPDPD---HANNCVILGLSMINHIMEVRDIHGLD--INMRIGVHSGNLFAGVIGEAKLQ 411
            .|:||  |:.:   ||.......|.:::.|......|..|  :.:|||.|:|.:..||:|....:
Worm  1012 FVSGL--PEVNSYLHAGEVASASLELLDSIKTFTVSHCPDEKLRLRIGNHTGPVVTGVVGIRMPR 1074

  Fly   412 FDIWGLDVTIANVLESTGVPGCVHISGATLNNLDVNRFDIEDG--PEEARDHPLLK-KYRIRSYI 473
            :.::|..|.|||::||:|.|..:.||.      |.....::.|  ..|.|:..:|| |..:.:|
Worm  1075 YCLFGDTVIIANMMESSGEPMRIQISS------DAYELILKCGGYVTEQREKIVLKNKLEVMTY- 1132

  Fly   474 IRQDLHMDDEDSDEFLGDL-----------HSISLCNMGAQ 503
                 .|:|...|..|..|           |.|...|.|.:
Worm  1133 -----WMNDYSKDARLARLVAHQEKFPHLEHLIHKFNKGVR 1168

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	13/49 (27%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	49/175 (28%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147
gcy-11	NP_001359843.1	Periplasmic_Binding_Protein_type1	<234..452	CDD:385651
		PKc_like	640..890	CDD:389743
		CYCc	923..1116	CDD:214485	57/219 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900