DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXE and acy-4

DIOPT Version :9

Sequence 1:	NP_652601.3	Gene:	ACXE / 53426	FlyBaseID:	FBgn0040506	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	NP_504486.4	Gene:	acy-4 / 178949	WormBaseID:	WBGene00000071	Length:	1013	Species:	Caenorhabditis elegans

Alignment Length:	1082	Identity:	282/1082 - (26%)
Similarity:	471/1082 - (43%)	Gaps:	237/1082 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 ERRSIIY---------------FDVALSIGC---------------ALVL-ILVLSVNFCDEFIA 104
            ::||.:|               |.:.||| |               :|:| ||.|.::....|.|
Worm    76 KKRSTLYSFYFEQVNSGRIQFSFVILLSI-CISEAAFSAFGAEWLKSLILCILTLVISILSFFHA 139

  Fly   105 KHTWYMYASSIFASLTLVFADLTESIYHTYAHSWILGTFYDTYIIYMIYMFLPIHFISGAVLLAL 169
            |.|..:..:||. |..::.|..:.....||            .:|:..|..||:.|:       |
Worm   140 KRTELVCIASII-SCVIISACTSMRTSVTY------------LLIFSTYSLLPMSFM-------L 184

  Fly   170 LVSGLYILYFVIFIAQGFAQFASAL--FSVGGMSVDIV-----HYLCLNLVGIFYRVMNDTVVRS 227
            ::...:.|.|::       .|...|  ::||   .||:     ..:.:|:||.......:.|.|.
Worm   185 MIFSTFALTFLV-------AFIGVLMDYNVG---FDIILTRVMMVILVNVVGSLVYYPTEFVQRK 239

  Fly   228 SFLDRHQYIKEKIWLRNARLQEKQLLDSILPPQISLPLQKDIQGRIVMAKQGIHSWTAMER---T 289
            :|.:..:.::.::.|.....:::::|.::||..|:..::||:|.            |..||   .
Worm   240 TFHETRKCVQSRMLLDKEMHRQEKILLAVLPKNIAFEVKKDMQE------------THEERMFHK 292

  Fly   290 MAIQIHPDVSILYADVVNYTHLTTTLTVEMLVKVLHDLYGRFDLAAYRYKVQRIKFLGDCYYCVA 354
            :.|:.:.|:|||:||:..:|:|.:....:.||.:|::|:.|||..|..::..|||.||||||||.
Worm   293 IYIRKYEDISILFADICGFTNLASEYNPKDLVLMLNELFARFDKVASIHQCMRIKILGDCYYCVC 357

  Fly   355 GLSDPDPDHANNCVILGLSMINHIMEVRDIHGLDINMRIGVHSGNLFAGVIGEAKLQFDIWGLDV 419
            |:.:...:||.|.|.:|..||..|..||::..:::|||:|:|:|....||:|..|.|||:|..||
Worm   358 GVPEYQKNHAINTVEMGRDMIEAIRLVREMTLVNVNMRVGIHTGKAHCGVLGLKKWQFDVWSNDV 422

  Fly   420 TIANVLESTGVPGCVHISGATLNNLDVNRFDIEDGPEEARDHPLLKKYRIRSYIIRQDLHMD-DE 483
            |:||.:||.|:.|.|||:.||.:.|. ..:.:|:|...:|. ..|:|.:|:::::     :| ..
Worm   423 TLANQMESGGLAGRVHITDATRSYLK-GAYILEEGNGGSRS-KFLEKEKIKTWLV-----VDRSP 480

  Fly   484 DSDEFLGDL--HSI-----SLCNMGAQPRISDSANQSLRALFHEELREEFRKMPVSAFSPKRLLG 541
            |.|....:.  |.:     |...:..|.|::..:.::..|.....|.||  ::.|.........|
Worm   481 DYDNICQEATNHPVMVPWKSTRGISKQERLTGMSTRTRGASTRNGLSEE--EVLVENVDSHLRQG 543

  Fly   542 ICRFNTGKEVPAHQNLNICLTFTDPILERAY--LKQTDYMYK---YSIILSASVGCSLVYIELMD 601
            |...:.......|.. |..|.:....:|..:  ||..|..::   |..|::..:|.....:.|:.
Worm   544 IQAIHQENWKTMHCK-NWSLKYKQVRVENKFVRLKYKDIPFQVTLYVAIVAICIGIKFGLMNLVS 607

  Fly   602 TQMICSSCFVLPASVATIQCILALIAWYKKYCWTRYGRNNVPHHYNGFSCFIFRIHDKILNSLPI 666
            ...: ...|::..||.......|||         ::.|                     |.||.|
Worm   608 FSFV-PQMFIVLTSVMIFILTRALI---------KHAR---------------------LVSLVI 641

  Fly   667 RICIYLFLMISSFFVMCLIVMSCQREEFEMAYIEERLFHYEQEAHICFHPWVTTNMLSLMIC--L 729
            .:   ||:::|   :..:|:|.....:|..            :...||....|.......||  .
Worm   642 GV---LFILLS---IQIVILMGMYESKFTC------------DVEKCFKNNYTDFFEIFEICTLA 688

  Fly   730 TFTFAHIPIMVKTAVAILETLAYLLLIFFQFDFVFHHSVTTNPY--FKSEYAH-ALLICITFLIM 791
            |.....:..|.|..::::...::.:||..:.       :..|.|  ..|.||: .:|.|:|.|::
Worm   689 TCVILSVDFMTKLLMSMIYFSSFTVLITAKL-------IRINQYEALLSTYANFCVLSCLTLLLV 746

  Fly   792 FVKERQIEFTNKVNFNWRVDLRKEENAASLTNHSIIIILNNILPSHIVDVYLNSLAKH------- 849
            ....|:.|..::.:|.|::....|:......:.....:|.||||||:        |||
Worm   747 VFSTRRSELISRYDFIWKLQALDEQLQMKRKHEQNRSVLENILPSHV--------AKHFVEDATS 803

  Fly   850 --ELYFENYRMVSVMFAMLINF-----EMD-----LRSLRVLNEIIAEFDTLL---LFYKEYYTV 899
              :||.|:.....:|||.|..|     |.|     :..||:|||||::||.:|   |..:|:..:
Worm   804 VSKLYHESRDNACIMFATLTEFDKFYIECDGNNEGVECLRLLNEIISDFDQILDQILDREEFKKI 868

  Fly   900 EKIKIVGCTYMAACGLDLNFAGSTSTNRKESIPPTEFNEEQSRRILFQQSNEDLDEVVFVMTSYA 964
            ||||.:..|||.|.||.....|..|.                               |..:..:|
Worm   869 EKIKTISTTYMVASGLAGRECGDNSH-------------------------------VEAIALFA 902

  Fly   965 LDMMRTLAKSNEAYQSIAGDRNITDGTIAIGISSGEVMAGIVGASQPHYDIWGNPVNMASRMEST 1029
            .:::..|..:|        ..:..:..:.|||:.|.|:||::|:.:||||||||.||:||||:|.
Worm   903 RELLVKLESTN--------IHSFNNFNLRIGINVGPVVAGVIGSDKPHYDIWGNSVNVASRMDSG 959

  Fly  1030 GLPGHIHVTEETSEILQQFGITCSYRGMTFVKGRGKIPTYLV 1071
            |:.|.|.||||...||:..|.....||...|||:|.:.|:.:
Worm   960 GVAGRIQVTEEVKSILEPLGYNFECRGQINVKGKGMMETFFL 1001

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	51/238 (21%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	70/168 (42%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147	78/232 (34%)
acy-4	NP_504486.4	AC_N	<50..291	CDD:292831	54/257 (21%)
		CYCc	260..451	CDD:214485	78/203 (38%)
		Guanylate_cyc	293..448	CDD:278633	67/154 (44%)
		CYCc	778..984	CDD:214485	81/252 (32%)
		Guanylate_cyc	807..1003	CDD:278633	78/234 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910