DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXE and gcy-18

DIOPT Version :9

Sequence 1:	NP_652601.3	Gene:	ACXE / 53426	FlyBaseID:	FBgn0040506	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	NP_502449.2	Gene:	gcy-18 / 178237	WormBaseID:	WBGene00001543	Length:	1113	Species:	Caenorhabditis elegans

Alignment Length:	264	Identity:	65/264 - (24%)
Similarity:	122/264 - (46%)	Gaps:	59/264 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 RVMNDTVVRS--SFLDR-----HQYIK--EKI------WLRNARLQEKQLLDSILPPQISLPLQK 267
            |:..:.|:::  |.:|:     .||..  ||:      .|..|.::..|||..:||..::..|:
Worm   841 RLNTEMVLKTKGSLVDQMMKMMEQYANNLEKLVAERTGMLEEANIRADQLLTQLLPAYVANELK- 904

  Fly   268 DIQGRIVMAKQGIHSWTAMERTMAIQIHPDVSILYADVVNYTHLTTTLTVEMLVKVLHDLYGRFD 332
                              |.|::|.:::...:||::|:|.:|.:.:..|...:|.:|:.||..||
Worm   905 ------------------MGRSVAPKLYSSATILFSDIVGFTTICSGSTPLEVVNMLNGLYTGFD 951

  Fly   333 LAAYRYKVQRIKFLGDCYYCVAGLSDPDP-DHANNCVILGLSMINHI----MEVRDIHGLDINMR 392
            ....|.|..:::.:||.|..|:|:.:.:. :|:.|.....|.|..::    :..|..|  .:..|
Worm   952 ECITRNKSYKVETIGDAYMVVSGIPEENEYNHSRNIANTALDMRQYLTGYQIPHRPTH--RVRCR 1014

  Fly   393 IGVHSGNLFAGVIGEAKLQFDIWGLDVTIANVLESTGVPGCVHISGATLNNLDVNRFDIEDGPEE 457
            .|.|:|::.|||:|....::.::|..|.:::.:||||.||.:.:|                  ||
Worm  1015 WGFHTGSVAAGVVGLTCPRYCLFGDTVNVSSRMESTGTPGMIQMS------------------EE 1061

  Fly   458 ARDH 461
            |..|
Worm  1062 AHMH 1065

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	16/68 (24%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	45/173 (26%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147
gcy-18	NP_502449.2	Periplasmic_Binding_Protein_Type_1	87..448	CDD:299141
		ANF_receptor	87..395	CDD:279440
		PKc_like	549..846	CDD:304357	1/4 (25%)
		HNOBA	<857..903	CDD:285003	11/45 (24%)
		CYCc	882..1073	CDD:214485	56/223 (25%)
		Guanylate_cyc	909..1095	CDD:278633	47/177 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900