Protein Alignment ACXE and acy-1

DIOPT Version :9

• Sequence 1: NP_652601.3
• Gene: ACXE / 53426
• FlyBaseID: FBgn0040506
• Length: 1123
• Species: Drosophila melanogaster
• Sequence 2: NP_497970.1
• Gene: acy-1 / 175622
• WormBaseID: WBGene00000068
• Length: 1253
• Species: Caenorhabditis elegans
• Alignment Length: 1330
• Identity: 309/1330 - (23%)
• Similarity: 501/1330 - (37%)
• Gaps: 409/1330 - (30%)

  Fly    16 RMWEPGYLKA-------KCAELRLESEFR---LY---RIRLWKSYLLTF---FMLHIFVTSVHCA 64
            |.|.|.:..|       ||:..:|...||   :|   .|..|..||..|   |:.|..|:...||
 Worm    39 RWWNPQFRSATLEAQYWKCSFSQLRDRFRSGLIYIAVVIAAWTLYLALFDRTFIQHWIVSLCLCA 103

  Fly    65 LLLA----TIERRSIIYFDVALSIGCALVLILVLSVNFCDEFIAKHTWYMYASSIFASLTLVFAD 125
            ::.|    |........|.:..|..|..::.||                         ..|:|:.
 Worm   104 IIFAMFAFTACAAQYQRFYMPTSFLCTFLICLV-------------------------TLLIFSA 143

  Fly   126 LTESIYHTYAHSWILGTFYDTYIIYMIYMFLPIHFISGAVLLALLVSGLYILYFVIF----IAQG 186
            ..::.:.|...|  |.|.:.  ::.:||..:|:     .:.|.:|:..:|.:.|.|.    |...
 Worm   144 ENQAAFMTPVAS--LATSFQ--VVLLIYTVIPL-----PLYLCILIGIIYSILFEILNKNKIGLE 199

  Fly   187 FAQFASALFSVGGMSVDIVHYLCLNLVGIFYRVMNDTVVRSSFLDRHQYIKEKIWLRNARLQEKQ 251
            .|.:...:...|      ||     |:|:...::.....|.:||...|.:..:..|......:..
 Worm   200 EAGYIKLVLHAG------VH-----LLGVHLFILTQVRQRKTFLKVGQSMLARKDLELETQFKDH 253

  Fly   252 LLDSILPPQISLPLQKDIQG------------RIVMAKQGIHSWTAME------RTMAIQIHPDV 298
            ::.|::|.:::..|.||...            |...|.|.......|.      |...:.:..:|
 Worm   254 MIQSVMPKKVADELLKDASELRRPSASNDSNCRTSNATQVDQPLAKMVPEYRKFRPFTMNLMTNV 318

  Fly   299 SILYADVVNYTHLTTTLTVEMLVKVLHDLYGRFDLAAYRYKVQRIKFLGDCYYCVAGLSDPDPDH 363
            |||:||:..:|.:::..:.:.||.:|:||:||||.......:::|..||||||||||..:|..||
 Worm   319 SILFADIAGFTKMSSNKSADELVNLLNDLFGRFDTLCRLRGLEKISTLGDCYYCVAGCPEPCDDH 383

  Fly   364 ANNCVILGLSMINHIMEVRDIHGLDINMRIGVHSGNLFAGVIGEAKLQFDIWGLDVTIANVLEST 428
            |...|.:||.||..|.:.....|.::|||:|:|:|.:..|::|..:.:||::..|||:||.:||:
 Worm   384 ACRTVEMGLDMIVAIRQFDIDRGQEVNMRVGIHTGKVMCGMVGTKRFKFDVFSNDVTLANEMESS 448

  Fly   429 GVPGCVHISGATLNNLDVNRFDIEDGPEEARDHPL----------LKKYRIRSYIIR-------- 475
            ||.|.||:|.||...|. ..::||:||:  .|.||          :|...::::.|:
 Worm   449 GVAGRVHVSEATAKLLK-GLYEIEEGPD--YDGPLRMQVQGTERRVKPESMKTFFIKGRINDGVE 510

  Fly   476 ---------QDLHMDDEDSDEFL--------------------------GDLHSISLC--NMGAQ 503
                     :.||.........|                          |.|. |.|.  |...|
 Worm   511 EEVMQVQEVESLHSQKSSKKSTLKQKWAEKLKMNHTNSYPMRAAAREGGGSLR-IKLAERNRSTQ 574

  Fly   504 --PRISDS--------ANQSLRAL-------FHEELREEFRKMPVS-AFSPKRLLG--------- 541
              |:.|:|        .:.||:||       .:.:....:.:..|: :.|.|.:.|
 Worm   575 LLPKESNSICIMEDNRKSASLQALATNNFNGSNTDTNNTYSERGVAGSVSKKSVAGSESNSIKGS 639

  Fly   542 ----------------------------------ICRFNTGKEVPA------------------- 553
                                              :.||:|......
 Worm   640 RSSGLQLSLQDGNSDLNSVGGLDTAISHHHNAASLTRFDTDNNFDQRLAMVIGQGEGGFDKGFWN 704

  Fly   554 -HQNLN-ICLTFTDPILERAYL-------------------KQTDYM----------------YK 581
             |.:|| ..|.|.:..:|..|.                   :..|.|                |:
 Worm   705 HHDSLNKWTLRFNEKDVEEEYRAHFVDSSERYTASKKGHVERHKDLMEQGGEKDGITGSTVNKYR 769

  Fly   582 YSIILSASVGCSLVY-----IELMDTQ-----MICSSCFVLPASVATIQCI-LALIAWYKKY-CW 634
            ||.:....:..:|::     :.:|..:     :|....|.....:.||..| |.|:|..|.: |.
 Worm   770 YSGVFIDIIVATLIFVISGAVAIMSVRPFPLSLIAYFPFAAAILILTIVLIGLPLLARKKSFQCA 834

  Fly   635 TRYGRNNVPHHYNGFSCFIFRIHDKILNSLPIRICIYLFLMISSFFVMCLIVMSCQREEFEMAYI 699
            .::    :|.|..|.          :|..|||.:.|            |::.: ||..:.....:
 Worm   835 NQW----MPRHLIGL----------LLIFLPIGVAI------------CIMPL-CQSGDCANVIL 872

  Fly   700 EERL-FHYEQEAHICFHPWVTTNMLSLMICLTFTFAHIPIMVKTAVAILETLAYLLLIFFQFDFV 763
            ..|| |.|           ||.    |.|.....|:.:....||..|:...|.::..:|: .:|.
 Worm   873 NYRLAFSY-----------VTI----LAIFAHCNFSQLAAWPKTTAAVFIGLLHIAGVFY-CEFN 921

  Fly   764 FHHSV----TTN---------------------------------PYFKSEYAHALLICITFLIM 791
            ..|.|    |.|                                 |.|..|....:::.|. |:.
 Worm   922 LKHLVEEQDTCNVTAIMIPPIRKGLNYTIALNSTSARTLSQDFGSPLFIWELLLDVILSIV-LVA 985

  Fly   792 FVKERQIEFTNKVNFNWRVDLRKEENAASLTNHSIIIILNNILPSHIVDVYLNSLAKHELYFENY 856
            |: ..|.|...:::|...|..|::.....:.......:|||::|:|.|:    ||.....|.||:
 Worm   986 FL-NYQFETAFRMSFFGDVQARRDTERMQIVRDQADWLLNNVIPAHAVE----SLKTDTKYSENH 1045

  Fly   857 RMVSVMFAMLI--------NFEMDLRSLRVLNEIIAEFDTLLLFYKEYYTVEKIKIVGCTYMAAC 913
            ..|.|:||.:.        |||.....||||||:|.:||. ||...::..:||||.:|..||||.
 Worm  1046 ETVGVLFASITNWNDMYEENFEGGREFLRVLNEVIGDFDE-LLDRPDFTHIEKIKTIGPAYMAAS 1109

  Fly   914 GLDLNFAGSTSTNRKESIPPTEFNEEQSRRILFQQSNEDLDEVVFVMTSYALDMMRTLAKSNEAY 978
            ||                     |.|:.:.:|..:      |.::.|..:||.:...|:..||
 Worm  1110 GL---------------------NPERKKNMLHPK------EHLYQMVDFALAVQHVLSVFNE-- 1145

  Fly   979 QSIAGDRNITDGTIAIGISSGEVMAGIVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTEETSE 1043
                 |....|....:|::.|.|.||::|.::.:|||||:.||:||||.|||:...|.|::.|.|
 Worm  1146 -----DLLNFDFVCKLGLNIGPVTAGVIGTTKLYYDIWGDTVNIASRMYSTGVLNRIQVSQHTRE 1205

  Fly  1044 -ILQQFGITCSYRGMTFVKG-RGKIPTYLV 1071
             :|.::..  .:|....||| .|.:.|||:
 Worm  1206 YLLDRYEF--EFRDHIEVKGIDGGMDTYLL 1233

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	52/269 (19%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	68/168 (40%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147	76/229 (33%)
acy-1	NP_497970.1	MreD	127..>223	CDD:294686	24/140 (17%)
		CYCc	297..469	CDD:214485	66/172 (38%)
		Guanylate_cyc	317..503	CDD:278633	73/188 (39%)
		SDF	<773..982	CDD:294387	45/251 (18%)
		CYCc	1016..1215	CDD:214485	77/239 (32%)
		Guanylate_cyc	1041..1235	CDD:278633	77/230 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810