Protein Alignment ACXE and acy-3

DIOPT Version :10

• Sequence 1: NP_652601.3
• Gene: ACXE / 53426
• FlyBaseID: FBgn0040506
• Length: 1123
• Species: Drosophila melanogaster
• Sequence 2: NP_497765.4
• Gene: acy-3 / 175489
• WormBaseID: WBGene00000070
• Length: 1243
• Species: Caenorhabditis elegans
• Alignment Length: 1201
• Identity: 237/1201 - (19%)
• Similarity: 438/1201 - (36%)
• Gaps: 339/1201 - (28%)

  Fly    10 LNYSKERMW-EPGYLKAKCAELRLESEFRLYRIRLW----KSYLLT------FFMLHIFVTSVHC 63
            :.:|.|  | |..||     :.|..:..||.||.|:    .::|.|      |:.|...|
 Worm     1 MGFSSE--WLEQSYL-----DWRHAASARLIRIVLFITSGSAFLRTLGHIPGFYALWTAV----- 53

  Fly    64 ALLLATIERRSIIY----------FDVALSIGCALVLILVLSVNFCDEFIAKHTWYMYASSIFAS 118
            .|||:|:   :||:          |.:...|      :|:|.|.|.         .....|:|.:
 Worm    54 ILLLSTV---TIIFHILRPARIAAFQILAGI------VLLLDVAFA---------LPGYESLFPA 100

  Fly   119 LTLVFADLTESIYHTYAHSWILGTFYDTYIIYMIYMFLPIHFISGAVLLALLVSGLYILYFVIFI 183
            |..||     |:|          ||:.          ||.:.|   :..:.|:|.:....|::|:
 Worm   101 LLAVF-----SLY----------TFFS----------LPFYAI---LATSTLISIVQTCSFLLFV 137

  Fly   184 AQGFAQFASALFSVGGMSVDIVHYLCLNLVGIFYRVMNDTVVRSSFLDRHQYIKEKIWLRNARLQ 248
                    ..|.:...:::.:|| :..|..||:.....|.:.|::||......:.:   ..|..|
 Worm   138 --------EPLHTNELLAIIVVH-IWTNFTGIYLCSTADRLARNAFLSARNSSEAE---STAEFQ 190

  Fly   249 E---KQLLDSILPPQISLPLQKDIQGRIVMAKQGIHSWTAMERTMAIQIHPDVSILYADVVNYTH 310
            .   .:||.|.||..              :..|..|..|..:..:..:.:..||:.|..:|.:..
 Worm   191 SNRLNKLLSSFLPYH--------------LINQARHQITLYKPHLYNETYSQVSVAYGRLVGFES 241

  Fly   311 LTTTLTVEMLVKVLHDLYGRFDLAAYRYKVQRIKFLGDCYYC-VAGLSDPDPDHANNCVILGLSM 374
            :....:.....:||.:|..|.:..|......|:...|....| :.|:   |..||.......:.:
 Worm   242 VLAQCSSIDAARVLKELDSRIERLAASNGCTRVASEGITAVCSIPGI---DSQHATKLCRFSMEL 303

  Fly   375 INHIMEVRDIHGLDINMRIGVHSGNLFAGVIGEAKLQFDIWGLDVTIANVLESTGVPGCVHISGA 439
            ...|...||..|.|:::.||:.||.:.|||:|.:|..:|:.|.....|.:::|......|::|..
 Worm   304 ETLINSFRDATGADVSVCIGIDSGPVTAGVVGVSKWHYDVIGSVFDNALLMQSNATEPGVYVSNE 368

  Fly   440 TLNNL-DVNRFDIEDGP---------EEARDHPLLKKYRIRSY------IIRQDLHMDDEDSDEF 488
            |...| ....|::|..|         ......|:.|::.:.:.      :::..:.|:.
 Worm   369 TRRFLGSTGEFELEKCPIGWKLYGHLPSPELFPVNKRFSLVTVPQAVNRVLQSIVAMNP------ 427

  Fly   489 LGDLHSISLCNMGAQPRISDSANQSLRALFHEELREEFRKMPVSAFSPKRLLGICRFNTGKEVPA 553
                   :|..||...:.....:|.                              :|:..|:...
 Worm   428 -------TLKTMGTNKKRKGEKSQE------------------------------KFDMQKKKVE 455

  Fly   554 HQNLNICLT--FTDPILERAYLKQTDYMYKYSIILS----ASVGCSLVYIELMDTQMICSSCFVL 612
            |..:...|:  |.:|.||..|.|:||:.:..|:.:|    ...|   :|..|:..::|.|...::
 Worm   456 HSTIISTLSQRFRNPGLEAEYHKETDHWFIPSLAISIFFLVVYG---IYHMLVMPRLITSLALIV 517

  Fly   613 PASVATIQCILALIAWYKKYCWTRYGRNNVPHHYNGFSCFIFRIHDKILNSLPIRICIYLFLMIS 677
            .|.......:|.|...|                ::.||.||.|      .|....:.|.|.::|
 Worm   518 GALTVMFFILLMLYIDY----------------FHTFSQFITR------TSAGHAVSIILIIVI- 559

  Fly   678 SFFVMCLIV--MSCQREEFEMAYIEERLFHYEQEAHI---CFHPWVTTNMLSLMICLTFTFAHIP 737
             .|| |.||  .||.:.......         |:||.   .|..|..|         |..|...|
 Worm   560 -LFV-CGIVNTFSCPQPNAPDVC---------QKAHFSTYSFAMWTIT---------TAVFVRFP 604

  Fly   738 IMVKTAVAILETLAYLLLIFFQFDFVFHHSVTTNP--YFKSEYAHAL-LICITFLI-----MFVK 794
            .:....:.|:..|.|.|.|:           .|.|  :...|:...| |.|  |||     :|:.
 Worm   605 SVYLAILLIISLLTYGLQIY-----------VTRPDEFGPREFMTELDLSC--FLISLVSMVFLH 656

  Fly   795 ERQIEFTNKVNFNWRV----DLRKEENAASLTNHSIIIILNNILPSHIVDVYLNSLAKHELYFEN 855
            .|:.|...:::|...|    :...::...:|.|..::    |::|:|:....:....  :::..:
 Worm   657 SRRCERLLRLDFLAVVKGIEETSMKDKLINLNNQMLL----NLVPAHVAPGVIQKAG--DVWHHS 715

  Fly   856 YRMVSVMFAMLINFEMDLRS-LRVLNEIIAEFDTLLLFYKEYYTVEKIKIVGCTYMAACGLDLNF 919
            ::.|.:.:..:..|:::..: :..||.:.:.||..:..||   .|||:|.....|:.|.||
 Worm   716 HQSVGIAYIAVSGFDLEGEAGINGLNYVFSHFDQAIANYK---GVEKVKSANRFYIVAVGL---- 773

  Fly   920 AGSTSTNRKESIPPTEFNEEQSRRILFQQSNE---DLDEVVFVMTSYALDMMRTLAKSNEAYQSI 981
                       :|...           |..||   .:.|::..:..:.:.:.: .|..||.:
 Worm   774 -----------LPDAA-----------QNVNETPWTIGELMSTLAHFIISISQ-FAMENEFH--- 812

  Fly   982 AGDRNITDGTIAIGISSGEVMAGIVGASQPHYDIWGNPVNMA-SRMESTGLPGHIHVTEETSEIL 1045
                      :.||:..|..:|.:....||.|:|:|..::.: :.|::.|        .:|:.:.
 Worm   813 ----------VQIGVDCGSTLAFVANTDQPRYEIFGETLDRSRTLMQAAG--------HDTTLVS 859

  Fly  1046 QQFGITCSYRGMTFVKGRGKIP---------TYLVGIDENLNFIPQKATRFPSHQERSTVISLQS 1101
            ::..:....|.:.|.....|:.         |.|..:..::..:|::      .|||.|...:::
 Worm   860 EEVFLALRPRPLRFSSQPVKVAMNLNAYELVTGLRDVSVDIPTMPRE------EQERHTQGMVEA 918

  Fly  1102 TYTH---------AENNNSIASTSRHTLQSL 1123
            .:.:         :|..:|:||:....|:|:
 Worm   919 QFANQSRMYDTQTSEMASSMASSFSSELRSI 949

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AcyC	65..453	CDD:441717	87/402 (22%)
		Nucleotidyl_cyc_III	290..459	CDD:448371	41/179 (23%)
		Nucleotidyl_cyc_III	851..1071	CDD:448371	40/233 (17%)
acy-3	NP_497765.4	AcyC	6..380	CDD:441717	102/460 (22%)
		Nucleotidyl_cyc_III	221..382	CDD:448371	39/163 (24%)
		CYCc	696..873	CDD:214485	39/229 (17%)