Protein Alignment ACXE and gcy-12

DIOPT Version :9

• Sequence 1: NP_652601.3
• Gene: ACXE / 53426
• FlyBaseID: FBgn0040506
• Length: 1123
• Species: Drosophila melanogaster
• Sequence 2: NP_494995.2
• Gene: gcy-12 / 173902
• WormBaseID: WBGene00001538
• Length: 1679
• Species: Caenorhabditis elegans
• Alignment Length: 1180
• Identity: 203/1180 - (17%)
• Similarity: 376/1180 - (31%)
• Gaps: 424/1180 - (35%)

  Fly   158 IHFISGAVLLALLVSGLYILYFVIFIAQGFAQFASALFSVGGMSVDIVHYLC---------LNLV 213
            |..|..|:...:..:.:|:.:      .....|.:.|..:|.|.:....|:.         ||:
 Worm   315 IQSIENAIKSTMQTTRIYLTF------DNVRLFRTMLSIMGEMGLTQQDYMLIYVDTNYDWLNV- 372

  Fly   214 GIFYRVMNDTVVRSSFLDRHQYIKEKIWLRNARLQEKQLLD------SILPPQISLPLQKDIQGR 272
               |..||:..:|::....|.     .|..| ...::::||      ||:|..:.|..|:...
 Worm   373 ---YHSMNNHFLRNTMTYLHH-----SWDAN-NSSDRKMLDYARSALSIIPTPVKLNSQRFYN-- 426

  Fly   273 IVMAKQG--IHSWTAMERTMAIQIHPDVSILYADVVNYTHLTTTL--TVEMLVKVLHDL---YGR 330
             ...|.|  :|.:               .:..||.:....:...|  .|.:..|.:|:|   ||.
 Worm   427 -FWKKAGDYMHHF---------------GVQKADNLKGNRIACYLYDAVYLYAKAIHELVEEYGN 475

  Fly   331 FDLAAYRYKVQRIKFLGDCYYCVAGLSDPDPDHANNCVILGLSMINHIM--EVRDIHGLDINMRI 393
                            .|.|       ||..|        |.::|:.|:  :.|.|.|.|  |||
 Worm   476 ----------------DDSY-------DPTAD--------GKAIIDRIVNKKYRSIQGFD--MRI 507

  Fly   394 GVHSGNLFAGVIGEAKLQFDI--WGLDVTIAN-----------VLESTGV--------------- 430
            ...         |.:|..|.:  |.....|.|           .|:.|.:
 Worm   508 DER---------GNSKGNFSLLSWQKVAPIMNKSDPSYYPLDHALDLTAIFVEAPDKDRLPNLQF 563

  Fly   431 ----------------PGC----------------------------VHISGATLNNLDVNRFDI 451
                            |.|                            :.::|.|||.:...||:.
 Worm   564 KSSRIQWLKGEPPPDEPVCGFHGENCRKKGIFSYLTVVVMILIAVFSLVLTGFTLNYIRSRRFEK 628

  Fly   452 EDGPEEARDHPLLKKYRIRSYIIRQDLHMDDEDSD------------------------------ 486
            |          |...::|..|.:|:.:...:.:|.
 Worm   629 E----------LSMIWKIDPYEVRRVVGGVNNESTASLMQSDVMQFAKTKTPWWSKAPVQGTGMR 683

  Fly   487 ---EFLGDLHSISLCNMGAQPR-ISDSANQSLRA---LFHEELREEFRKMPVSAFSPKRLLGICR 544
               .:.|.|..:.....|.:|: ::..|.:.|||   |.|..: ..|..:.|..:|...:...|.
 Worm   684 GLASYKGTLVGLKDLMYGRKPKDLTREAKKELRAMRQLAHPNV-NNFLGIIVCQYSVTVVREYCS 747

  Fly   545 FNTGKEVPAHQNLNICLTFTDPILERAYLKQTDYMYKYSIILSASVGCSLVYI---------ELM 600
            ..:..::..::||.:                 |:||..|.:.....|  :|||         .|.
 Worm   748 KGSLHDILRNENLKL-----------------DHMYVASFVDDLVKG--MVYIHDSELKMHGNLK 793

  Fly   601 DTQMICSSCFVLPASVATIQCILALIAW------YKKYCWT---------RYGRNNVPHHYNGFS 650
            .|..:.:|.:.|..:...::.:...|.:      ::.:.||         ....:|.|.......
 Worm   794 STNCLITSRWTLQIADFGLRELREGIMYDSSYNIWENFLWTAPEAMTINGSLAISNPPTPKADAY 858

  Fly   651 CFIFRIHDKILNSLPIRICIYLFLMISSFFVMCLIVMSCQREEF--EMA----YIEERLFHYEQE 709
            .|....|:......|.:|.:                   ||.:.  |.|    .:|.|....:..
 Worm   859 SFGIIFHEIFTREGPYKIYV-------------------QRGDVNGEAAPKKDSVECRALVEKTV 904

  Fly   710 AHICFHPWVTTNMLSLMICLTFTFAHIPIMVKTAVAILETLAYLLLIFFQFDFVFHHSVTTNPYF 774
            ..:...|:...:...|         .:...||..:|.                .:||.....|.|
 Worm   905 RRVYSDPYFRPDTSDL---------EVQNYVKEVMAA----------------CWHHDPYQRPEF 944

  Fly   775 KS-----------EYAHALLICITFLIMFVKERQIEFTNKVNFNWRVDLRKEENAASLTNHSIII 828
            |:           .|...::   ..:::.:::.|.:..:.|: ...::|:.|:..   :.|
 Worm   945 KTIKNKLKPLFHQIYKQNIM---DHMVLMMEKYQTQLEDLVD-ERTIELKDEQRR---SQH---- 998

  Fly   829 ILNNILPSHIVDVYLNSLAKHELYFENYRMVSVMFAMLINF------EMDLRSLRVLNEIIAEFD 887
            :|..:|||.:.:   ..||..::..|.:..|::.|:.::.|      ...:..:..||::...||
 Worm   999 LLQRMLPSSVAE---QLLAGQDVIPEAFPPVTIYFSDIVGFTTISGESTPMEVVTFLNKLYTLFD 1060

  Fly   888 TLLLFYKEYYTVEKIKIVGCTYMAACGLDLNFAGSTSTNRKESIPPTEFNEEQSRRILFQQSNED 952
            :::    ..|.|.|::.:|..||...|:             ......|::.||
 Worm  1061 SII----RRYDVYKVETIGDAYMVVSGV-------------PQYKTMEYHAEQ------------ 1096

  Fly   953 LDEVVFVMTSYALDMMRTLAKSNEAYQSIAGDRNITDGTIAIGISSGEVMAGIVGASQPHYDIWG 1017
                :.:|..:.|..:|:.:..:.:.:.:         .|.||:.:|..:||:||.:.|.|.::|
 Worm  1097 ----IAMMAIHILSAVRSFSIPHRSCEPL---------MIRIGMHTGPCVAGVVGKTMPRYTLFG 1148

  Fly  1018 NPVNMASRMESTGLPGHIHVTEETSEILQQF--GITCSYRGMTFVKGRGKIPTYL---------- 1070
            :.||.||||||.|....||.:..|.::|...  |.....||...:||:|::.||.
 Worm  1149 DTVNTASRMESNGEALRIHCSSSTQKVLTSIDQGFLLEERGSLAIKGKGQMTTYWLNGRAGYEFT 1213

  Fly  1071 --------------------------VGIDENLNFIPQKATRFPSHQERSTVISLQSTYTHAENN 1109
                                      |..:.:|:...:|:::....|..:...:.|....:.:..
 Worm  1214 ETIEDKMVVPDIFPRPNLKNRGSSWGVNRESSLSLATEKSSQIMKRQSAAMNRNNQDVIYYNQPL 1278

  Fly  1110 NSIASTSRHT 1119
            ||...|||.|
 Worm  1279 NSGGFTSRGT 1288

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	25/128 (20%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	41/247 (17%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147	53/263 (20%)
gcy-12	NP_494995.2	PBP1_Speract_GC_like	123..545	CDD:107365	59/305 (19%)
		ANF_receptor	140..519	CDD:279440	55/279 (20%)
		PK_GC-A_B	648..957	CDD:270944	54/372 (15%)
		TyrKc	688..951	CDD:197581	53/326 (16%)
		HNOBA	<967..1012	CDD:285003	9/55 (16%)
		CYCc	991..1183	CDD:214485	53/243 (22%)
		Guanylate_cyc	1018..1206	CDD:278633	53/229 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900