DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXE and gcy-28

DIOPT Version :9

Sequence 1:	NP_652601.3	Gene:	ACXE / 53426	FlyBaseID:	FBgn0040506	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	NP_001021600.1	Gene:	gcy-28 / 172051	WormBaseID:	WBGene00020131	Length:	1276	Species:	Caenorhabditis elegans

Alignment Length:	1195	Identity:	225/1195 - (18%)
Similarity:	381/1195 - (31%)	Gaps:	430/1195 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 SGLYILYFVIF-----------IAQGFAQFASALFSVGGMSVDIVH-YLCLNLVGIFYRVMNDTV 224
            |.|..|..:.|           |||..:|...|..|         | |..|..:..::...:.|.
Worm   197 SSLNYLNLIFFYHDKRRAVNRVIAQDESQETGATSS---------HCYFSLYAIKRYFTEKSKTF 252

  Fly   225 VRSSFLDRHQYIKE----------KIWLRNARLQEKQLLDSILPPQISLPLQKDIQGRIVMAKQG 279
            .|...|:..|:..:          |.|||...||...::         |....|....|::|...
Worm   253 KREWALNTPQFPFDEDLVIERETFKQWLREISLQSNVII---------LCASPDTVREIMLAAHD 308

  Fly   280 IHSWTAMERTMAIQIHPDVSI--------LYADVVNYTHLTTTLTVEMLVKVLHDLYGRFDLAAY 336
            :...|:.|   .:.|:.|||.        :.|:..|.............:|.:.  ..|.||..|
Worm   309 LGMATSGE---YVFINIDVSTGSHAEQPWIRANDTNNEENEKAKEAYRALKTIS--LRRSDLDEY 368

  Fly   337 RYKVQRIKFLGDCYYCVAGLSDPDPDHAN------NCVILGLSMINHIMEVRDIHGLDINMRIGV 395
            :....|:|...|..|....::..|.:..|      :.|:|....:|..::    .|||......:
Worm   369 KNFELRVKERADQKYNYTNITGKDYEMNNFISAFYDAVLLYAIALNETIQ----SGLDPRNGHNI 429

  Fly   396 HS---GNLFAGVIGEAKL--------QFDIWGLD------VTIA------NVLESTG-------- 429
            .|   |..|.|:.|...:        .:.:..||      |.:|      |.|::.|
Worm   430 TSRMWGRTFVGITGNVSIDHNGDRYSDYSLLDLDPVQNRFVEVAYYSGASNQLKTVGQLHWVGGK 494

  Fly   430 ----VPGC-----------VHI---SGATLNNLDV--------NRFDIE---------------D 453
                :|.|           :|:   .|:.|..|.:        .|:.:|               |
Worm   495 PPTDLPICGYDKSKCPGYPLHVYLLMGSFLLILVLVGLFIFFWRRYKLEQELAAMSWKIRWEELD 559

  Fly   454 GPE-----------EARDH--------PLLKKYRIRSYIIRQDLHMDDEDSDEFL---------- 489
            |.|           :.::|        |||:.      ..|..::.|..|.|..:
Worm   560 GEESQKKNEKKKAKKRKNHNDYLPESDPLLRS------TSRSSVNSDKFDEDSLIPIRFRLRSSS 618

  Fly   490 -GDLHSISLC---------------------NMGAQP--------------------------RI 506
             |....||..                     |.|..|                          |:
Worm   619 SGTTRKISAMIDRKLSIFTRKKSTPPSESQKNGGLTPNSLQKAENGDCSPINEVQFRLPLNDRRV 683

  Fly   507 SDSANQSLRAL-FHEELREEFRKMPVSAFSPKRLLGICRFNTGK----EVPAHQN---------- 556
            |..::::.|.. .:||..|...|..:|..:.|...|:..|.:|.    |..|..|
Worm   684 SSPSSEATRKKNSNEEDPENGAKKSLSLKNRKLSFGMVSFKSGSGGSVETIAQNNTQIYTKTAIF 748

  Fly   557 ---------LNI-----------------------------------CLTF-------------- 563
                     |||                                   |:.|
Worm   749 KGVVVAIKKLNIDPKKYPRLDLSRAQLMELKKMKDLQHDHITRFTGACIDFPHYCVVTEYCPKGS 813

  Fly   564 TDPILERAYLKQTDYMYKYSIILSASVGCSLVYI-------ELMDTQMICSSCFVLPAS---VAT 618
            .:.|||...: :.|.:.|||::.....|...::.       .|..:..:..|.|||..:   :..
Worm   814 LEDILENEKI-ELDKLMKYSLLHDLVKGLFFLHNSEIRSHGRLKSSNCVVDSRFVLKVTDFGLHR 877

  Fly   619 IQCI-------LALIAWYKKYCWTRYGRNNVPHHYNGFSCFIFRIHDKILNSLPI---RICIYLF 673
            :.|:       :...|:|||..||      .|.          .:.|.  |:.|:   :..||.|
Worm   878 LHCLEEINLEEIGEHAYYKKMLWT------APE----------LLRDS--NAPPMGTQKGDIYSF 924

  Fly   674 LMISSFFVMCLIVMSCQREEFEMAYIEERLFHYEQEAHICFHPWVT------------TNMLSLM 726
            .:|....:....|.:.:.|:.....|.:|:.....|......|||:            ..:||||
Worm   925 AIILHEMMFRKGVFALENEDLSPNEIVQRVRKPVSEDQEPLRPWVSETGEGEGDDALNDTLLSLM 989

  Fly   727 ICLTFTFAHIPIMVKTAVAILETLAYLLLIFFQFDFVFHHSVTTNPYFKSEYAHALLICITFLIM 791
            :.......|....|.:....:.:|.             ..:.|:|                 |:.
Worm   990 VACWSEDPHERPEVSSVRKAVRSLN-------------RDNETSN-----------------LVD 1024

  Fly   792 FVKERQIEFTNKVNFNWRVDLRKEENAASLTNHSIIIILNNILPSHIVDVYLNSLAKHELYFENY 856
            .:.:|..::.|  |....|:.|.:|..|.  ...:..:|:.:||..|.|..   :|...:..|:|
Worm  1025 NLLKRMEQYAN--NLEGLVEERTQEYLAE--KKKVEELLHQLLPPAIADTL---IAGRAVQAESY 1082

  Fly   857 RMVSVMFAMLINF------EMDLRSLRVLNEIIAEFDTLLLFYKEYYTVEKIKIVGCTYMAACGL 915
            ..|::.|:.::.|      ...::.:.:||::...||.::..:|.|    |::.:|..||...||
Worm  1083 DCVTIYFSDIVGFTSLSSQSTPMQVVTLLNDLYLAFDGVVDNFKVY----KVETIGDAYMVVSGL 1143

  Fly   916 DLNFAGSTSTNRKESIPPTEFNEEQSRRILFQQSNEDLDEVVFVMTSYALDMMRTLAKSNEAYQS 980
                                           .:..:|....:..|:...|..::.....:..::.
Worm  1144 -------------------------------PERRDDHANQIAQMSLSLLHKVKNFVIRHRPHEQ 1177

  Fly   981 IAGDRNITDGTIAIGISSGEVMAGIVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTEETSEIL 1045
            :         .:.||:.||.|:||:||:..|.|.::|:.||.:|||||.|||..|||:::|.:||
Worm  1178 L---------KLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLPLKIHVSQQTYDIL 1233

  Fly  1046 -QQFGITCSYRGMTFVKGRGKIPTY 1069
             |:.|.....||...:||:|...||
Worm  1234 MQEAGFKLELRGSVEMKGKGMQTTY 1258

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	25/121 (21%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	46/265 (17%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147	57/226 (25%)
gcy-28	NP_001021600.1	PBP1_NPR_like	42..486	CDD:107368	63/315 (20%)
		ANF_receptor	64..465	CDD:279440	59/294 (20%)
		PK_GC-A_B	722..1016	CDD:270944	53/325 (16%)
		STYKc	741..1008	CDD:214568	47/285 (16%)
		HNOBA	<1026..1071	CDD:285003	12/48 (25%)
		CYCc	1050..1233	CDD:214485	53/231 (23%)
		Guanylate_cyc	1077..1262	CDD:278633	57/226 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910