DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXE and Gucy2e

DIOPT Version :9

Sequence 1:	NP_652601.3	Gene:	ACXE / 53426	FlyBaseID:	FBgn0040506	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	XP_036012232.1	Gene:	Gucy2e / 14919	MGIID:	105123	Length:	1139	Species:	Mus musculus

Alignment Length:	286	Identity:	80/286 - (27%)
Similarity:	122/286 - (42%)	Gaps:	67/286 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   829 ILNNILPSHIVDVYLNSLAKHELYFENYRMVSVMFAMLINF------EMDLRSLRVLNEIIAEFD 887
            :|..:||..:.:......:....|||.   |::.|:.::.|      ...:..:.:||::...||
Mouse   886 LLTQMLPPSVAEALKMGTSVEPEYFEE---VTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFD 947

  Fly   888 TLLLFYKEYYTVEKIKIVGCTYMAACGLDLNFAGSTSTNRKESIPPTEFNEEQSRRILFQQSNED 952
            .::..:..|    |::.:|..||.|.||.                     :...:|...:.:|..
Mouse   948 AIIGAHDVY----KVETIGDAYMVASGLP---------------------QRNGQRHAAEIANMS 987

  Fly   953 LDEVVFVMTSYALDMMRTLAKSNEAYQSIAGDRNITDGTIAIGISSGEVMAGIVGASQPHYDIWG 1017
            ||    ::::.....||.:.:              ....|.||:.||..:||:||.:.|.|.::|
Mouse   988 LD----ILSAVGSFRMRHMPE--------------VPVRIRIGLHSGPCVAGVVGLTMPRYCLFG 1034

  Fly  1018 NPVNMASRMESTGLPGHIHVTEETSEIL----QQFGITCSYRGMTFVKGRGKIPTY-LVGIDENL 1077
            :.||.||||||||||..|||...|..||    |.|.:.|  ||.|.:||:|...|| |||   .|
Mouse  1035 DTVNTASRMESTGLPYRIHVNMSTVRILRALDQGFQMEC--RGRTELKGKGIEDTYWLVG---RL 1094

  Fly  1078 NF---IPQKATRFPSHQERSTVISLQ 1100
            .|   ||:.....|......  ||||
Mouse  1095 GFNKPIPKPPDLQPGASNHG--ISLQ 1118

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454
		Nucleotidyl_cyc_III	290..459	CDD:325147
		Nucleotidyl_cyc_III	851..1071	CDD:325147	65/230 (28%)
Gucy2e	XP_036012232.1	PBP1_sensory_GC_DEF-like	58..465	CDD:380594
		PK_GC-2D	570..845	CDD:270945
		HNOBA	<854..899	CDD:400168	3/12 (25%)
		CYCc	879..1070	CDD:214485	58/229 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810