DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXE and gucy2f

DIOPT Version :9

Sequence 1:	NP_652601.3	Gene:	ACXE / 53426	FlyBaseID:	FBgn0040506	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	NP_571939.2	Gene:	gucy2f / 140424	ZFINID:	ZDB-GENE-011128-7	Length:	1107	Species:	Danio rerio

Alignment Length:	1257	Identity:	241/1257 - (19%)
Similarity:	418/1257 - (33%)	Gaps:	425/1257 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 CAELRLE---SEFRLYRIRLWKSY-LLTF---FMLHIFVTSV---------HCALLLATIERRSI 75
            |..||..   |....|.|.||... :|||   ....:|...:         :...|.|...|.::
Zfish    21 CPVLRSRRSLSTLPFYSITLWIILGVLTFPRCVQCLVFKVGIIGPWNCDPNYAKSLPAIASRLAV 85

  Fly    76 --IYFDVALSIGCALVLILVLSVNFCDEFIAKHTWYMYASSIFASLT---------LVFADLTES 129
              |..|.:|.:||.:..:::.......:.:.....|...:..|...|         |:..:..:|
Zfish    86 GRINNDFSLDLGCTMDFVILQEACETSKALTSFVQYENVADAFVGPTNPGYCNAAALMSKNWDKS 150

  Fly   130 IYHTYAHSW---------ILGTFYDTY---------IIYMIYMF--------------------- 155
            ::     ||         :.|  |.|:         :::.:..|
Zfish   151 LF-----SWACVNHELDRVQG--YPTFARTLPSPLRVLFNVLKFFRWANIGIVSSNEDIWIDTAA 208

  Fly   156 ----------LPIHFISGA---------VLLALLVSG-----LYILYFVIFIAQGFAQFASALFS 196
                      ||:..::..         .|:::..:|     :..::.|:...:..|.|.:..:.
Zfish   209 KLASALRNRGLPVGIVTSMGNNDTMLENTLMSIKNAGDIKVIIMCMHSVLIGGEQQATFLTKAYD 273

  Fly   197 VGGMSVDIVHYLCLNLVGIFYRVMNDTVVRSSFLDRHQYIKEKIWLRNARLQEKQLLDSILPPQI 261
            :|..|            |.:..:..||::.|.     .||.    :....||....|.......:
Zfish   274 MGLAS------------GRYVFIPYDTLLYSL-----PYIN----ITYYPLQNNSKLSKAYDAVL 317

  Fly   262 SLPLQKDIQGRIVMAKQGIHSWTAMERTMAIQIHPDVSILYADVVNYTHLTTTLTVEMLVKVLHD 326
            ::.|..|    |:...:..::...:...|..|....||.|:..:.|..:|        |.|.:|:
Zfish   318 TITLDSD----IMTFNEAFNAAKQLGELMVTQEPEQVSPLFGTIYNSLYL--------LAKSMHN 370

  Fly   327 L--YGRF----DLAAYRYKVQRIKFLG---DCYYCVAGLSDPDPDHANNCVIL-----GLSMINH 377
            .  .||:    :||   |..:.|.|.|   |..      :|...:...|.|||     |..:...
Zfish   371 ARRAGRWLSGTNLA---YFTRNITFTGFNQDIQ------TDEQGNGQTNYVILDTEAWGTQLYRC 426

  Fly   378 IMEVRDIHGLDINMRIGVHSGNLFAGVIGEAKLQFD--IW---------GLD---VTIANVLEST 428
            .:       :|:...:.:.:|. |....||:....|  .|         |:|   |.||.|:...
Zfish   427 FL-------VDMTSDLVLFAGR-FIHFPGESPPPSDSRCWFEDNAICTGGVDIIYVIIAFVIVLI 483

  Fly   429 GVPGCVHISGATLNNLDVNRFDIEDGPEE----ARD----HPLLKKYRI--------RSYIIRQD 477
            .|.|.:.:|  ......:.:..:..||..    ..|    :|.|.|.:|        :|||
Zfish   484 IVLGSIGLS--LFIRRRIQQIQLIKGPNRILLTLEDLTFINPQLSKRKITLEDLSDSKSYI---- 542

  Fly   478 LHMDDEDSDEFLGDLHSISLCNMGAQPRISDSANQSL-------RALFHEELREEFRKMPVSAFS 535
                   .::..|| .|.|:.:|.....  :::|.::       ...|.|...:|.::.....|:
Zfish   543 -------EEKSTGD-RSRSVNSMATATH--ETSNVAVYEGDWVWLKKFTEGHFKEVKQSTTKIFT 597

  Fly   536 PKRLLGICRFNTGKEVPAHQNLNICL-TFTD-----------------PILERAYLKQTDYMYKY 582
            ..:.|            .::|:|..| .|||                 .:|....:| .|:|:|.
Zfish   598 KMKDL------------RNENVNPFLGFFTDCEMFAIVTEHCSRGSLHDLLRNDDVK-LDWMFKS 649

  Fly   583 SIILSASVGCS-LVYIELMDTQMICSSCFVLPASVATIQCILALIAWYKKYCWTRYGRNNV---- 642
            |::|....|.. |.:.|....::...:|.|....|..|               |.||.|.:
Zfish   650 SLVLDLIKGMKYLHHREFPHGRLKSRNCVVDGRFVLKI---------------TDYGYNEILETQ 699

  Fly   643 ----------------PHH-----------YNGFSCFIFRIHDKILNSLPIRICIYLFLMISSFF 680
                            |.|           |.| ..:.|.|   ||..:.:|...|..|.:|.
Zfish   700 KAPKETLPPEDLFWTAPEHLRDPESPRKGTYKG-DVYSFAI---ILQEVVVRGAPYCMLGLSP-- 758

  Fly   681 VMCLIVMSCQREEFEMAYIEERLFHYEQEAHICFHPWVTTNMLSLMICLTFTFAHIPIMVKTAVA 745
                               ||.:...::...:| .|.|..:.                      |
Zfish   759 -------------------EEIIRKVKKPPPMC-RPTVAPDQ----------------------A 781

  Fly   746 ILETLAYLLLIFFQ-------FDFVFHHSVTTNPYFKSEYAHALLICI----TFLIMFVKERQIE 799
            .||.:..:...:.:       ||.:|......|...|:....::|..:    :.|...::||..|
Zfish   782 PLECIQLMKQCWSEQPDRRPPFDQIFDQFKLINKGKKTNIIDSMLRMLEQYSSNLEDLIRERTEE 846

  Fly   800 FTNKVNFNWRVDLRKEENAASLTNHSIIIILNNILPSHIVDVYLNSLAKHELYFENYRMVSVMFA 864
            .        .|:.::.|.           :|:.:||..:.:......:....||:   .|::.|:
Zfish   847 L--------EVEKQRTEK-----------LLSEMLPPSVAEALKTGASVEPEYFD---QVTIYFS 889

  Fly   865 MLINFEM------DLRSLRVLNEIIAEFDTLLLFYKEYYTVEKIKIVGCTYMAACGLDLNFAGST 923
            .::.|..      .:..:.:||::.:.||.:|..:..|    |::.:|..||.|.||
Zfish   890 DIVGFTTISSLSDPIEVVDLLNDLYSLFDAVLGSHDVY----KVETIGDAYMVASGL-------- 942

  Fly   924 STNRKESIPPTEFNEEQSRRILFQQSNEDLDEVVFVMTSYALDMMRTLAKSNEAYQSIAGDRNIT 988
                     |.:...:.:..|    :|..|:    :::|.....||.:.:              .
Zfish   943 ---------PKKNGNKHAAEI----ANMSLN----ILSSVGSFKMRHMPE--------------V 976

  Fly   989 DGTIAIGISSGEVMAGIVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTEETSEILQQF--GIT 1051
            ...|.|||.||..:||:||.:.|.|.::|:.||.||||||||||..|||...|.:||:..  |..
Zfish   977 PVRIRIGIHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNISTVQILRSLNDGYK 1041

  Fly  1052 CSYRGMTFVKGRGKIPTY-LVG 1072
            ...||.|.:||:|...|| |||
Zfish  1042 IDVRGKTELKGKGIEETYWLVG 1063

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	49/330 (15%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	43/200 (22%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147	65/228 (29%)
gucy2f	NP_571939.2	PBP1_sensory_GC_DEF_like	59..440	CDD:107366	66/436 (15%)
		PK_GC-2D	551..816	CDD:270945	57/342 (17%)
		HNOBA	<825..870	CDD:311573	10/63 (16%)
		CYCc	850..1042	CDD:214485	61/248 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900