Protein Alignment ACXE and ACXD

DIOPT Version :10

• Sequence 1: NP_652601.3
• Gene: ACXE / 53426
• FlyBaseID: FBgn0040506
• Length: 1123
• Species: Drosophila melanogaster
• Sequence 2: XP_061503573.1
• Gene: ACXD / 1269596
• VectorBaseID: AGAMI1_009197
• Length: 1215
• Species: Anopheles gambiae
• Alignment Length: 1227
• Identity: 400/1227 - (32%)
• Similarity: 613/1227 - (49%)
• Gaps: 217/1227 - (17%)

  Fly    11 NYSKERMWEPGYLKAKCAELRLESEFRLYRIRLWKSYLLTFFMLHIFVTSVHCALLL-------A 68
            :|...:.||.|:|:.:|..|.||:.:..|..|:.:|||..|.:|..||:..|..:::       |
Mosquito    36 DYIALKKWELGFLRRECVNLGLETFYLKYMERVQRSYLSIFVVLQTFVSISHVIVIVTGKPHPTA 100

  Fly    69 TIERRSIIY-FDVALSIGCALVLILVLSVNFCDEFIAKHTWYMYASSIFASLTLVFADLTESIYH 132
            .|....|.| |.:       |::.:.|...|.:..:..:.|..|.||..|.:|::..|||..:||
Mosquito   101 AIHPDLICYLFGI-------LIVWISLFAAFKEGLVKAYPWVPYVSSSIAVITMIITDLTIPLYH 158

  Fly   133 TYAHSWILGTF--------YDTYIIYMIYMFLP----IHFISGAVLLALLVSGLYILYFVIFIAQ 185
            ...      ||        |.::.|..||:|||    ||.|       :|.|...:.|.::....
Mosquito   159 AVV------TFINPPLRPSYASHTILAIYIFLPLTENIHGI-------ILGSATSLCYLIVMTLI 210

  Fly   186 GFAQFASALFSVGGMSVDIVHYLCLNLVGIFYRVMNDTVVRSSFLDRHQYIKEKIWLRNARLQEK 250
            .:....:....|   ..::::::||||.|:::|::|:..:|.:||||.:.::..:.|:.||.|||
Mosquito   211 TYRLEENTALKV---ITELIYFICLNLFGLYFRLINEVAIRRTFLDRRELVEGNLLLKFARNQEK 272

  Fly   251 QLLDSILPPQISLPLQKDIQGRIVMAKQGIHS----------------WTAMERTMAIQIHPDVS 299
            :||.||||...:..::|||:..|...:...|:                |.::.: :.:|.|.:|:
Mosquito   273 ELLLSILPEHTAELMEKDIRAMIEKMRNDQHNANQTINTQNFFRTGTQWRSINK-LYVQKHTNVT 336

  Fly   300 ILYADVVNYTHLTTTLTVEMLVKVLHDLYGRFDLAAYRYKVQRIKFLGDCYYCVAGLSDPDPDHA 364
            |||||||||||:||.|.|..||.|||:|:.:||.|:..:.|.||||||||||||:|:...:..||
Mosquito   337 ILYADVVNYTHMTTQLPVRTLVDVLHELFVKFDEASKEFNVLRIKFLGDCYYCVSGVPVRNKYHA 401

  Fly   365 NNCVILGLSMINHIMEVRDIHGLDINMRIGVHSGNLFAGVIGEAKLQFDIWGLDVTIANVLESTG 429
            .:||.|||.||..|.:||....|:|:||||:|||::.:||||..|.|:|||..||.|||.:||||
Mosquito   402 KSCVNLGLRMIKDIRDVRMSRDLNIDMRIGIHSGSIISGVIGACKWQYDIWSKDVIIANKMESTG 466

  Fly   430 VPGCVHISGATLNNLDVNRFDIEDGPEEARDHPLLKKYRIRSYIIRQDLHMDDEDSDEFLGDLHS 494
            ..|.||::..||..|| ..:..|:|..:|:|.|:|.|:.|::::|......||       |...:
Mosquito   467 EAGKVHVTMQTLELLD-GEYIFEEGTPQAKDDPILVKHNIQTFLIVPQPGYDD-------GSFFT 523

  Fly   495 ISLCNMGAQPRISDSANQSL----RAL----FHEELREEFR---------------KMPVSAFSP 536
            :.  ..|...|:|....:..    |:|    |.:...|:||               :||:..|..
Mosquito   524 VQ--EPGPSSRMSSGVKRKTIKKERSLVTRNFMQNSMEQFREIMKLTNVEMAYELERMPIGRFQF 586

  Fly   537 KRLLGICRFNTGKEVPAH--------QNLNIC---------------LTFTDPILERAYLKQTDY 578
            .:|..  .:.|..:.|:|        :|...|               :.|.:...|.:||::.|.
Mosquito   587 NKLFS--SYKTYMQEPSHTSAPARTVENGPRCSEEDTNRLDNMSPFFMCFENKRWELSYLQEPDL 649

  Fly   579 MYKYSIILSASVGCSLVYIELMDTQMICSSCFVLPASVATIQCILAL--IAWYKKYCW------- 634
            |.|||:::|..|...::.|::::.   .|..:....:..:...:||.  |.|:|| .|
Mosquito   650 MLKYSVLMSFIVFVCILLIQILND---ASGIYFWLLNGLSGALLLAFIPITWFKK-VWDVYTPYS 710

  Fly   635 ------TRYGRNNVPHHYNGFSCFIFRIHDKILNSLPIRICIYLFLMISSFFVMC--LIVMSCQR 691
                  .|..::.|...:..||       :.|:::..||..|||..:  :..|:|  :.::.|..
Mosquito   711 IDDLLRVRKPQSRVMRIFYDFS-------NDIMSNFVIRTVIYLITI--ALLVVCSLMYLIECNY 766

  Fly   692 EEFEMAY-----IEERLFHYEQE---------AHICFHPWVTTNMLSLMICLTFTFAHIPIMVKT 742
            :..|...     :.:.|....||         .:.|.:||..|..|:|.|.:.|.|..|..::|.
Mosquito   767 DLLEQTSTTSVPVSDNLTSLFQENQTSPDPMAKNFCTNPWSVTQCLTLAIGMAFLFLRIHFLLKA 831

  Fly   743 AVAILETLAYLLLIFFQFDFVFHHSVTTNPYFKSEYAHALLICITFLIMFVKERQIEFTNKVNFN 807
            ||.:|....|...||....:.|..|.:.||....:.:|.:||....:|....:||.|:..:.::|
Mosquito   832 AVGLLIFFFYCWAIFDDLYYYFDSSASMNPGLDPKVSHLMLILFIVIIFHWIDRQSEYIARTDYN 896

  Fly   808 WRVDLRKEENAASLTNHSIIIILNNILPSHIVDVYLNSLAKHELYFENYRMVSVMFAMLINFEM- 871
            |:..|.|::..|.:|..:..|::.||||:|:.::|:|...|:|.|.|.|..|:||||.:.|.|:
Mosquito   897 WKQQLLKQKEEAEVTKQTNKILVENILPTHVAEIYINRQLKNEFYNEEYENVAVMFATITNMEVN 961

  Fly   872 -------DLRSLRVLNEIIAEFDTLLLFYKEYYTVEKIKIVGCTYMAACGLDLNFAGSTS----- 924
                   :...|:||||||.:||..|.::..|..|||||:.|.|||||||||.....|:|
Mosquito   962 TDISVENEKSVLKVLNEIICDFDERLQYFDGYLKVEKIKVAGWTYMAACGLDPGRCDSSSSLSGY 1026

  Fly   925 ------------TNRKESIPP-------------TEFNEEQSRRILFQQSNEDLDEVVFVMTSYA 964
                        ||.:.|:.|             |..|...||     .||    .|..||..:|
Mosquito  1027 RSVSGMTRTSLMTNGRRSLNPRTSLEVAHKASTSTRSNSSNSR-----HSN----NVTIVMAEFA 1082

  Fly   965 LDMMRTLAK-SNEAYQSIAGDRNITDGTIAIGISSGEVMAGIVGASQPHYDIWGNPVNMASRMES 1028
            |::||.|.. |||.:      :..:.|.:.:|||.|:||||:||:|:|.||||||.|||||||:|
Mosquito  1083 LELMRVLRDFSNENF------KQTSPGLLRVGISHGKVMAGVVGSSKPLYDIWGNAVNMASRMDS 1141

  Fly  1029 TGLPGHIHVTEETSEILQQFGITCSYRGMTFVKGRGKIPTYLVGIDENLNFIPQKAT 1085
            ||.||.|.||:|::|:||.:|..|.|||..|||||||||||.:.|..:|.|: :||:
Mosquito  1142 TGRPGRIQVTKESAEVLQSYGYQCDYRGEIFVKGRGKIPTYFLKIGSDLKFL-KKAS 1197

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AcyC	65..453	CDD:441717	152/423 (36%)
		Nucleotidyl_cyc_III	290..459	CDD:448371	89/168 (53%)
		Nucleotidyl_cyc_III	851..1071	CDD:448371	113/258 (44%)
ACXD	XP_061503573.1	None