DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXE and LRRK2

DIOPT Version :9

Sequence 1:	NP_652601.3	Gene:	ACXE / 53426	FlyBaseID:	FBgn0040506	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	NP_940980.4	Gene:	LRRK2 / 120892	HGNCID:	18618	Length:	2527	Species:	Homo sapiens

Alignment Length:	889	Identity:	168/889 - (18%)
Similarity:	293/889 - (32%)	Gaps:	247/889 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 VHYLCLNLVGIFYRVMNDTVVRSSFLDRHQYIKEKIWLRNARL------QEKQLLDSILPPQISL 263
            ||.|.|.::.:....:|.:|:....||        :.|.:.::      :|..:...|.....|.
Human   114 VHQLILKMLTVHNASVNLSVIGLKTLD--------LLLTSGKITLLILDEESDIFMLIFDAMHSF 170

  Fly   264 PLQKDIQGRIVMAKQGIHSWTAMERTMAIQI-----HPDVSILYADVVNYTHLTTTLTVEMLVKV 323
            |...::|   .:..:.:|  ...||....|:     :.|..||.:.:.|:..     ..|:::.|
Human   171 PANDEVQ---KLGCKALH--VLFERVSEEQLTEFVENKDYMILLSALTNFKD-----EEEIVLHV 225

  Fly   324 LHDLYGRFDLAAYRYKVQRIKFLGD--CYYCVAGLSDPDPDHANNCVILGLSMINHIMEVRD--I 384
            ||.|:   .||.....|: :...|:  ||..|.......|            |...|.||..  :
Human   226 LHCLH---SLAIPCNNVE-VLMSGNVRCYNIVVEAMKAFP------------MSERIQEVSCCLL 274

  Fly   385 HGLDINMRIGVHSGNLFAGVIGEAKLQFDIWGLDVTIANVLESTGVPGCVHISGAT--LNNLDVN 447
            |.|.:        ||.|..::.....:|.:..:.....|.........|:.:...|  ||.
Human   275 HRLTL--------GNFFNILVLNEVHEFVVKAVQQYPENAALQISALSCLALLTETIFLNQ---- 327

  Fly   448 RFDIEDGPEEARDHPLLKKYRIRSYIIRQDLHMDDEDSDEFLGDLHSI--SLCNMGAQPRISDSA 510
              |:|:..|...:                    |||..::.|..|.:.  :|........:.::|
Human   328 --DLEEKNENQEN--------------------DDEGEEDKLFWLEACYKALTWHRKNKHVQEAA 370

  Fly   511 NQSLRAL------FHEELREEFRKMPVSAFSPKRLLGICRFNTGKEV----------PAHQNLNI 559
            ..:|..|      .||::.:|....|...   :.:|.:...::.|||          ...||:|
Human   371 CWALNNLLMYQNSLHEKIGDEDGHFPAHR---EVMLSMLMHSSSKEVFQASANALSTLLEQNVN- 431

  Fly   560 CLTFTDPILERA-YLKQTDYMYKYSIILSASV---GCSLV--YIELMDTQMICSSCFV------- 611
               |...:|.:. :|...:.|.|:  |.|..|   ||.::  ..|..:|.:...:..|
Human   432 ---FRKILLSKGIHLNVLELMQKH--IHSPEVAESGCKMLNHLFEGSNTSLDIMAAVVPKILTVM 491

  Fly   612 ------LPASVATIQCILALIAWYKKYCWTRYGRNNVP------------HHYNGF---SCFIFR 655
                  ||..:..::.||..|               ||            ||....   .||...
Human   492 KRHETSLPVQLEALRAILHFI---------------VPGMPEESREDTEFHHKLNMVKKQCFKND 541

  Fly   656 IHDKILNSL-------PIRICIYLFLMISSFFVMCLIVMSCQREEFEMAYIEERLFHYEQEAHI- 712
            ||..:|.:|       .|:.|....:.....|...|.::|.   |..|..:...|..|..:..|
Human   542 IHKLVLAALNRFIGNPGIQKCGLKVISSIVHFPDALEMLSL---EGAMDSVLHTLQMYPDDQEIQ 603

  Fly   713 CF------------HPWVTTNML--SLMICLTFTFAHI-PIMVK---TAVAILETLAYL--LLIF 757
            |.            :.::.|..|  .:::...:.|..: .|..|   |.:|||:..|..  ||:.
Human   604 CLGLSLIGYLITKKNVFIGTGHLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSASFSKLLVH 668

  Fly   758 FQFDFVFHHSVTTNPYFKSEYAHALLICITF--------LIMFVKERQIEFTNKVNFNWRVDLRK 814
            ..||.|..|.:::|...:.:.....|.|..|        |...:.||..:..|.:.....:.|..
Human   669 HSFDLVIFHQMSSNIMEQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQNNSIMVECLLLLGA 733

  Fly   815 EENAASLTNHSIIIILNNILPSHIVDVYLNSLAKHE-----LYFENYRMVSVMFAMLIN------ 868
            :.|.|...:..|..:........:|::.|||.::.:     |.....:..|.:.::|:.
Human   734 DANQAKEGSSLICQVCEKESSPKLVELLLNSGSREQDVRKALTISIGKGDSQIISLLLRRLALDV 798

  Fly   869 -----------------------FEMDLRSLRVLNEIIAEFDTLLLFYKEYYTVEKIKIVGCTYM 910
                                   |.....:||....|.:....:::.|:....||:        .
Human   799 ANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLARMVIRYQMKSAVEE--------G 855

  Fly   911 AACGLDLNFAGSTSTNRKESIPPTEFNEEQSRRILFQQSNEDLD 954
            .|.|.|.||:....:...|    ..|..:.|...:|.|| :|||
Human   856 TASGSDGNFSEDVLSKFDE----WTFIPDSSMDSVFAQS-DDLD 894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	14/72 (19%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	36/179 (20%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147	24/133 (18%)
LRRK2	NP_940980.4	Required for RAB29-mediated activation. /evidence=ECO:0000269\|PubMed:29212815	1..969		168/889 (19%)
		LRR 1	983..1004
		leucine-rich repeat	985..1012	CDD:275380
		LRR	1012..>1286	CDD:227223
		LRR 2	1012..1033
		leucine-rich repeat	1013..1036	CDD:275380
		LRR 3	1036..1057
		leucine-rich repeat	1037..1084	CDD:275380
		LRR 4	1059..1080
		LRR 5	1084..1105
		leucine-rich repeat	1085..1108	CDD:275380
		LRR 6	1108..1129
		leucine-rich repeat	1109..1130	CDD:275380
		LRR 7	1130..1150
		leucine-rich repeat	1131..1174	CDD:275380
		LRR 8	1174..1196
		leucine-rich repeat	1175..1197	CDD:275380
		LRR 9	1197..1218
		leucine-rich repeat	1198..1221	CDD:275380
		LRR 10	1221..1241
		leucine-rich repeat	1222..1246	CDD:275380
		LRR 11	1246..1267
		leucine-rich repeat	1247..1269	CDD:275380
		LRR 12	1269..1291
		RocCOR	1334..1507	CDD:206741
		COR	1527..1740	CDD:318343
		STKc_LRRK2	1884..2135	CDD:270970
		WD 1	2139..2183
		WD 2	2188..2228
		WD 3	2233..2276
		WD 4	2281..2327
		WD 5	2333..2377
		WD 6	2402..2438
		WD 7	2443..2497
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900