Protein Alignment ACXE and Adcy9

DIOPT Version :9

• Sequence 1: NP_652601.3
• Gene: ACXE / 53426
• FlyBaseID: FBgn0040506
• Length: 1123
• Species: Drosophila melanogaster
• Sequence 2: XP_011244107.1
• Gene: Adcy9 / 11515
• MGIID: 108450
• Length: 1372
• Species: Mus musculus
• Alignment Length: 1333
• Identity: 310/1333 - (23%)
• Similarity: 523/1333 - (39%)
• Gaps: 374/1333 - (28%)

  Fly     1 MPRSL-GNCQLNYSKE----------RMWEPGY----LKAKCAELRLESEFRLYRIR-------- 42
            :||.: |..:|...|:          |.|:|.:    |:..|.|.......|.:|..
Mouse    63 LPRRVGGGGRLRRQKKLPQLFERASSRWWDPKFDSMNLEEACLERCFPQTQRRFRYALFYVGFAC 127

  Fly    43 -LWKSYLLTFFMLH------IFVTSVHCALLLAT---------IERRSIIYFDVALSIGCALVLI 91
             ||..|    |.:|      :.|....|.|::..         :..|...:..:||::   ||..
Mouse   128 LLWSIY----FAVHMKSKVIVMVVPALCFLVVCVGFFLFTFTKLYARHYAWTSLALTL---LVFA 185

  Fly    92 LVLSVNFCDEFIAKHTWYMYASSIFAS---LTLVFADLTESIYHTYAHSWILGTF---YDTYIIY 150
            |.|:..|       ..|...:..:.:|   ||...||...|         .:|:|   .:..::.
Mouse   186 LTLAAQF-------QVWTPLSGRVDSSNHTLTATPADTCLS---------QVGSFSICIEVLLLL 234

  Fly   151 MIYMFLPIHFISGAVLLALLVSGLYILYFVIFIAQGFAQFASALFSVGG--------MSVDIVHY 207
            ...|.||::       |:|.   |.::|.|:|...|:.......:...|        :|..::|
Mouse   235 YTVMQLPLY-------LSLF---LGVVYSVLFETFGYHFRNEDCYPSPGPGALHWELLSRALLH- 288

  Fly   208 LCLNLVGIFYRVMNDTVVRSSFLDRHQYIKEKIWLRNARLQEKQLLDSILPPQISLPLQK--DIQ 270
            :|::.:||...||:....||:||...|.|.....|...:..:::::.|::|..|:..|.|  |.:
Mouse   289 VCIHAIGIHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEE 353

  Fly   271 GRIVMAKQGIHSWTAMERTMAIQIHP------------DVSILYADVVNYTHLTTTLTVEMLVKV 323
            ....:.:....|....::..:||..|            :||||:||:|.:|.::...:...||.:
Mouse   354 SENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGL 418

  Fly   324 LHDLYGRFDLAAYRYKVQRIKFLGDCYYCVAGLSDPDPDHANNCVILGLSMINHI----MEVRDI 384
            |:||:||||....:.|.::|..||||||||||..:|..|||..|:.:||.||..|    .|.:::
Mouse   419 LNDLFGRFDRLCEQTKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEM 483

  Fly   385 HGLDINMRIGVHSGNLFAGVIGEAKLQFDIWGLDVTIANVLESTGVPGCVHISGATLNNLDVNRF 449
                :|||:|||:|.:..|::|..:.:||:|..||.:||::|..||.|.||||.||...|| :|:
Mouse   484 ----VNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLD-DRY 543

  Fly   450 DIEDGP--EEARDHPLLKKYR-IRSYII----RQDLHMD-----------DEDSDEFLG------ 490
            ::|||.  |......:..:.: :::|:|    .::.|..           .:||.|..|
Mouse   544 EMEDGRVIERLGQSVVADQLKGLKTYLISGQRAKESHCSCAEALLSGFEVIDDSRESSGPRGQGT 608

  Fly   491 -----------------DLHSISLCNM--------GA-----------QPRISDSANQSLRALFH 519
                             :|.:...|.:        ||           :|:.|.....|...
Mouse   609 ASPGSVSDLAQTVKTFDNLKTCPSCGITFAPKSEAGAEGGTVQNGCQDEPKTSTKVTSSWLL--- 670

  Fly   520 EELREEFRKMPVSAFSPK-------------------------------------RLLGI----- 542
                  |..:|:.|..||                                     |..|:
Mouse   671 ------FLSVPLLAHPPKASGGPNSKTQNGLLSPPAEEKLTNSQTSLCEILQEKGRWAGVSLDQS 729

  Fly   543 ----CRF-NTGKEVPAH-------QNL-----------NICLTFTDPILERAYLKQTDYMYKYSI 584
                .|| |..::..||       .:|           ...|.|.|..|||:|...    |:..:
Mouse   730 ALLPLRFKNIREKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTS----YQEEV 790

  Fly   585 ILSASVG--CSLVYIELMDTQMICSSCFVLPASVATIQCILALIAWYKKYCWTRYGRNNVPHHYN 647
            |.::.|.  .|..:..|:|..:           ..|:..||::.      |:.:||....|....
Mouse   791 IKNSPVKTFASATFSSLLDVFL-----------STTVFLILSIT------CFLKYGATATPPPPA 838

  Fly   648 GFSCFIFRIHDKILNSLPIRICIYLFLMISSFFVMCLIVMSCQREEFE----------------- 695
            ..:.|   ..|.:|..|.:.:.|.:...:..       ||:|.:...|
Mouse   839 ALAVF---GADLLLEVLSLIVSIRMVFFLED-------VMTCTKWLLEWIAGWLPRHCIGAILVS 893

  Fly   696 ---MAYIEERLFHYEQEAHICFHPWVTTNMLSLMICLTFTFAHIPIMVKTAVAILETLAYLLLIF 757
               :|........:|...|:..   .|.:.:.:.:.....|..:...:::::|.:.....|||:.
Mouse   894 LPALAVYSHITSEFETNIHVTM---FTGSAVLVAVVHYCNFCQLSSWMRSSLATIVGAGLLLLLH 955

  Fly   758 FQ-----------FDFVFHHSVTTNPYFKSEYAH----ALLI----CITF----LIMFVKERQIE 799
            ..           .|...:.|...||...|....    |.||    .:||    |:::...|:.|
Mouse   956 ISLCQDSSIVMSPLDSAQNFSAQRNPCNSSVLQDGRRPASLIGKELILTFFLLLLLVWFLNREFE 1020

  Fly   800 FTNKVNFNWRVDLRKEENAASLTNHSIIIILNNILPSHIVDVYLNSLAKHELYFENYRMVSVMFA 864
            .:.:::::..|:.................:|.||:|.|:.:    .|...:.|.:|:....|:||
Mouse  1021 VSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAE----QLKVSQTYSKNHDSGGVIFA 1081

  Fly   865 MLINF--------EMDLRSLRVLNEIIAEFDTLLLFYKEYYTVEKIKIVGCTYMAACGLDLNFAG 921
            .::||        |......|||||:|.:||. ||...:|.::||||.:|.|||||.||
Mouse  1082 SIVNFSEFYEENYEGGKECYRVLNELIGDFDE-LLSKPDYNSIEKIKTIGATYMAASGL------ 1139

  Fly   922 STSTNRKESIPPTEFNEEQSRRILFQQSNEDLDEVVFVMTSYALDMMRTLAKSNEAYQSIAGDRN 986
            :|:..::...|      ::..||||:               :|.:|||.:...|         .|
Mouse  1140 NTAQCQEGGHP------QEHLRILFE---------------FAKEMMRVVDDFN---------NN 1174

  Fly   987 IT--DGTIAIGISSGEVMAGIVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTEETSEILQQFG 1049
            :.  :..:.:|.:.|.:.||::|.::..|||||:.||:||||::||:...|.|:||:..:|.:.|
Mouse  1175 MLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMG 1239

  Fly  1050 ITCSYRGMTFVKGRGKIPTYLVGIDENLNFIPQ 1082
            ....|||...|||:|::.|||.....:...:||
Mouse  1240 YDFDYRGTVNVKGKGQMKTYLYPKCTDNGVVPQ 1272

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	58/280 (21%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	76/186 (41%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147	76/229 (33%)
Adcy9	XP_011244107.1	MFS	<134..260	CDD:391944	31/154 (20%)
		Guanylate_cyc	385..573	CDD:306677	75/192 (39%)
		Guanylate_cyc	1069..1260	CDD:306677	75/227 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810