Protein Alignment ACXE and Adcy7

DIOPT Version :10

• Sequence 1: NP_652601.3
• Gene: ACXE / 53426
• FlyBaseID: FBgn0040506
• Length: 1123
• Species: Drosophila melanogaster
• Sequence 2: XP_006530643.1
• Gene: Adcy7 / 11513
• MGIID: 102891
• Length: 1146
• Species: Mus musculus
• Alignment Length: 1171
• Identity: 326/1171 - (27%)
• Similarity: 522/1171 - (44%)
• Gaps: 251/1171 - (21%)

  Fly    43 LWKSYLLTFFMLHIFVTSVHCALLLATIERRSIIYFDVALSIGCALVLILVLSVNFCDEFIAKH- 106
            |::.|.|         ||:|..|||             .|.:..|...|.::|:.|..|.:.:|
Mouse    21 LYEKYRL---------TSLHGPLLL-------------LLLLVAAATCIALISIAFSHEDLRRHQ 63

  Fly   107 ----TWYMYASSIFASLTLVFAD-------------------------LTESIYHTYAHSWILGT 142
                |.::..:...|...||:.:                         :.:|: ...||:|....
Mouse    64 VVLGTAFLMLTLFVALYVLVYVECLVQRWLRALALLTWACLMVLGSVLMWDSL-ENEAHAWEQVP 127

  Fly   143 FYDTYIIYMIYMFLPIH----FISG--AVLLALLVSGLYILYFVIFIAQ---GFAQFASALFSVG 198
            |: .::::::|..||:.    .::|  :.:..|||.|.....|...::.   |....|:|:..:|
Mouse   128 FF-LFVVFVVYALLPLSRRAAIVAGVTSTVSHLLVFGAVTRAFQTSMSSTQLGLQLLANAVILLG 191

  Fly   199 GMSVDIVHYLCLNLVGIFYRVMNDTVVRSSFLDRHQYIKEKIWLRNARLQEKQLLDSILPPQISL 263
            |           |..|.|::.......|..|:...:.|:.:..||..:.|::.||.|:||..||:
Mouse   192 G-----------NFTGAFHKHQLQDASRDLFIYTVKCIQIRRKLRVEKRQQENLLLSVLPAHISM 245

  Fly   264 PLQ-------KDIQGRIVMAKQGIHSWTAMERTMAIQIHPDVSILYADVVNYTHLTTTLTVEMLV 321
            .::       |:...|..|.....||       :.::.|.:|||||||:|.:|.|.:..:.:.||
Mouse   246 GMKLAIIERLKEGGDRHYMPDNNFHS-------LYVKRHQNVSILYADIVGFTRLASDCSPKELV 303

  Fly   322 KVLHDLYGRFDLAAYRYKVQRIKFLGDCYYCVAGLSDPDPDHANNCVILGLSMINHIMEVRDIHG 386
            .||::|:|:||..|...:..|||.||||||||:||....|.||.|||.:||.:...|.:||:..|
Mouse   304 VVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDICEAIKQVREATG 368

  Fly   387 LDINMRIGVHSGNLFAGVIGEAKLQFDIWGLDVTIANVLESTGVPGCVHISGATLNNLDVNRFDI 451
            :||:||:|:||||:..||||..|.|:|:|..||::||.:|:.||||.|||:.||||:|| ..:::
Mouse   369 VDISMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEATLNHLD-KAYEV 432

  Fly   452 EDGPEEARDHPLLKKYRIRSYIIRQDLHMDDEDSDEFLGDLHSISLCNMGAQPRI-----SDSAN 511
            |||..|.|| |.||:..||:|::..............|......:...|.|..|:     |..|.
Mouse   433 EDGHGEQRD-PYLKEMNIRTYLVIDPRSQQPPPPSHHLSKPKGDATLKMRASVRVTRYLESWGAA 496

  Fly   512 QSLRALFHEE-------------------LREEFRKMPVSAFSPK-RLLGICRFNTGKEVPAHQN 556
            :....|.|.|                   ||.  .:.|..:.||| ||...|.......:....:
Mouse   497 RPFAHLNHRESVSSSETPISNGRRQKAIPLRR--HRAPDRSASPKGRLEDDCDDEMLSAIEGLSS 559

  Fly   557 LNICLTFTD------PI-LERAYLKQTDYMYKYSIILSA--SVGC-SLVYIELMDTQMICSSCFV 611
            ...|.:.:|      || ||:.:.::    |:...|..|  ...| |||::.::...::     |
Mouse   560 TRPCCSKSDDFHTFGPIFLEKGFERE----YRLVPIPRARYDFACASLVFVCILLVHLL-----V 615

  Fly   612 LP------ASVATIQCILALIAWYKKYCW-TRYGRNNVPHHYNGFSCFIFR-----IHDKILNSL 664
            :|      .|...:.|:|.|:.   .:|: |.:.|           ||..|     |.:.: .:.
Mouse   616 MPRMATLGVSFGLVACLLGLVL---SFCFATEFSR-----------CFPSRSTLQAISESV-ETQ 665

  Fly   665 PIRICIYLFLMISSFFVMCLIVMSCQREEFEMAYIEERLFHYEQEAHI---C-FHPWVTTN-MLS 724
            |:...:.:.|.:.|...:.:|.|............:.:......:..:   | ..|:.|.: :|.
Mouse   666 PLVRLVLVVLTVGSLLTVAIINMPLTLNPGPEQPGDNKTSPLAAQNRVGTPCELLPYYTCSCILG 730

  Fly   725 LMICLTFTFAHIPIMVKTAVAILETLAYLLLIFFQFDFVFH---HSVTTNPYFKSEY-------- 778
            .:.|  ..|..:.:.:|..:..:..:|||||  |.....:|   :|..||...::..
Mouse   731 FIAC--SVFLRMSLELKAMLLTVALVAYLLL--FNLSPCWHVSGNSTETNGTQRTRLLLSDAQSM 791

  Fly   779 -AHALL------------------ICITF-LIMF-----VKERQIEFTNKVNFNWRVDLRKEENA 818
             :|.|.                  |.:.| ||:|     :..|||::..:::..|:...:||...
Mouse   792 PSHTLAPGARETAPSPSYLERDLKIMVNFYLILFYATLILLSRQIDYYCRLDCLWKKKFKKEHEE 856

  Fly   819 ASLTNHSIIIILNNILPSHIVDVYLNSLAKHELYFENYRMVSVMFAMLINFEM----------DL 873
            .....:...::|.|:||:|:...::...|..:.|.::|..|.||||.:.:|::          .|
Mouse   857 FETMENVNRLLLENVLPAHVAAHFIGDKAAEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKEGL 921

  Fly   874 RSLRVLNEIIAEFDTLLLFYKEYYTVEKIKIVGCTYMAACGLDLNFAGSTSTNRKESIPPTEFNE 938
            ..||:||||||:||.|||..| :..|||||.:|.|||||.||              |.|....|:
Mouse   922 ECLRLLNEIIADFDELLLKPK-FSGVEKIKTIGSTYMAAAGL--------------SAPSGHENQ 971

  Fly   939 EQSRRILFQQSNEDLDEVVFVMTSYALDMMRTLAKSNEAYQSIAGDRNITDGTIAIGISSGEVMA 1003
            :..|:.:.          :.|:..:::.:|..|...|.        .:.....:.:||:.|.|:|
Mouse   972 DLERKHVH----------IGVLVEFSMALMSKLDGINR--------HSFNSFRLRVGINHGPVIA 1018

  Fly  1004 GIVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTEETSEILQQFGITCSYRGMTFVKGRGKIPT 1068
            |::||.:|.||||||.||:||||||||..|.|.|||||..|||..|.:|..||:..|||:|::.|
Mouse  1019 GVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGKGELRT 1083

  Fly  1069 Y 1069
            |
Mouse  1084 Y 1084

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AcyC	65..453	CDD:441717	134/433 (31%)
		Nucleotidyl_cyc_III	290..459	CDD:448371	84/168 (50%)
		Nucleotidyl_cyc_III	851..1071	CDD:448371	89/229 (39%)
Adcy7	XP_006530643.1	AcyC	48..456	CDD:441717	140/429 (33%)
		Guanylate_cyc	272..422	CDD:425528	74/149 (50%)
		Adcy_cons_dom	487..594	CDD:461877	22/112 (20%)
		Guanylate_cyc	890..1085	CDD:425528	89/228 (39%)