DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXE and ADCY9

DIOPT Version :9

Sequence 1:	NP_652601.3	Gene:	ACXE / 53426	FlyBaseID:	FBgn0040506	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	XP_005255136.1	Gene:	ADCY9 / 115	HGNCID:	240	Length:	1372	Species:	Homo sapiens

Alignment Length:	1338	Identity:	317/1338 - (23%)
Similarity:	535/1338 - (39%)	Gaps:	340/1338 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SKERMWEPGY----LKAKCAELRLESEFRLYRIRLWKSYLLTFFMLHIFVTSVHCALLLATIERR 73
            :..|.|:|.:    |:..|.|.......|.:|      |.|.:......:.|::.|     :..|
Human    86 ASSRWWDPKFDSVNLEEACLERCFPQTQRRFR------YALFYIGFACLLWSIYFA-----VHMR 139

  Fly    74 SIIYFDVALSIGCALVLILVLSVNFCDEFIAKHTWYMYASSIFASLTLVFA-------------- 124
            |.:...||.:: |.|::.:...:....:..|:|    ||.:..|...||||
Human   140 SRLIVMVAPAL-CFLLVCVGFFLFTFTKLYARH----YAWTSLALTLLVFALTLAAQFQVLTPVS 199

  Fly   125 ------DLTESIYHTYAHSWILGTF-YDTYIIYMIY--MFLPIHFISGAVLLALLVSGLYILYFV 180
                  :||.:...|......:|:| ....:::::|  |.||::       |:|.   |.:.|.|
Human   200 GRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLY-------LSLC---LGVAYSV 254

  Fly   181 IFIAQGFAQFASALFSVGG--------MSVDIVHYLCLNLVGIFYRVMNDTVVRSSFLDRHQYIK 237
            :|...|:.....|.|...|        :|..::|. |::.:|:...||:....||:||...|.|.
Human   255 LFETFGYHFRDEACFPSPGAGALHWELLSRGLLHG-CIHAIGVHLFVMSQVRSRSTFLKVGQSIM 318

  Fly   238 EKIWLRNARLQEKQLLDSILPPQISLPLQK--DIQGRIVMAKQGIHSWTAMERTMAIQIHP---- 296
            ....|...:..:::::.|::|..|:..|.|  |.:....:.:....|....::..:||..|
Human   319 HGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAFR 383

  Fly   297 --------DVSILYADVVNYTHLTTTLTVEMLVKVLHDLYGRFDLAAYRYKVQRIKFLGDCYYCV 353
                    :||||:||:|.:|.::...:...||.:|:||:||||......|.::|..||||||||
Human   384 PFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCV 448

  Fly   354 AGLSDPDPDHANNCVILGLSMINHI----MEVRDIHGLDINMRIGVHSGNLFAGVIGEAKLQFDI 414
            ||..:|..|||..|:.:||.||..|    .|.:::    :|||:|||:|.:..|::|..:.:||:
Human   449 AGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEM----VNMRVGVHTGTVLCGILGMRRFKFDV 509

  Fly   415 WGLDVTIANVLESTGVPGCVHISGATLNNLDVNRFDIEDGP--EEARDHPLLKKYR-IRSYIIRQ 476
            |..||.:||::|..||.|.||||.||...|| :|:::|||.  |......:..:.: :::|:|..
Human   510 WSNDVNLANLMEQLGVAGKVHISEATAKYLD-DRYEMEDGKVIERLGQSVVADQLKGLKTYLISG 573

  Fly   477 DLHMDDEDS--DEFLGDLHSISLCNMGAQPR---------ISDSANQSLRAL------------- 517
            ....:...|  :..|.....|....:.:.||         :||.| |:::..
Human   574 QRAKESRCSCAEALLSGFEVIDGSQVSSGPRGQGTASSGNVSDLA-QTVKTFDNLKTCPSCGITF 637

  Fly   518 ----------------FHEELREE---------FRKMPVSAFSPK-------------------- 537
                            ..:|.:..         |..:|:.|..||
Human   638 APKSEAGAEGGAPQNGCQDEHKNSTKVTSSWLLFLSVPLLAHPPKASGGPNPKTQNGLLSPPQEE 702

  Fly   538 -----------------RLLGI---------CRF-NTGKEVPAHQNLNICLTFTDPILERAYLKQ 575
                             |..|:         .|| |..::..||        |.|.|.|.:.:|
Human   703 KLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNIREKTDAH--------FVDVIKEDSLMK- 758

  Fly   576 TDYMYKYSI------ILSASVGCSLVYIELMDTQMICSS---CFVLPASVATIQCILALIAW--Y 629
             ||.:|..|      .|...:..|  |......::|.:|   .|..|...:.:...|:...:  .
Human   759 -DYFFKPPINQFSLNFLDQELERS--YRTSYQEEVIKNSPVKTFASPTFSSLLDVFLSTTVFLTL 820

  Fly   630 KKYCWTRYGRNNVPHHYNGFSCFIFRIHDKILNSLPIRICIYLFLMISSFFVMCLIVMSCQREEF 694
            ...|:.:|....||......:.|...:..::| ||.:.|.:..||.         .||:|.:...
Human   821 STTCFLKYEAATVPPPPAALAVFSAALLLEVL-SLAVSIRMVFFLE---------DVMACTKRLL 875

  Fly   695 E--------------------MAYIEERLFHYEQEAHICFHPWVTTNMLSLMICLTFTFAHIPIM 739
            |                    :|........||...|.   |..|.:...:.:.....|..:...
Human   876 EWIAGWLPRHCIGAILVSLPALAVYSHVTSEYETNIHF---PVFTGSAALIAVVHYCNFCQLSSW 937

  Fly   740 VKTAVAILETLAYLLLIFFQF--DFVFHHSVTTNPY-----FKSE-------------------- 777
            :::::|.:.....|||::...  |    .||.|:|.     |.||
Human   938 MRSSLATVVGAGPLLLLYVSLCPD----SSVLTSPLDAVQNFSSERNPCNSSVPRDLRRPASLIG 998

  Fly   778 YAHALLICITFLIMFVKERQIEFTNKVNFNWRVDLRKEENAASLTNHSIIIILNNILPSHIVDVY 842
            ....|:..:..|:::...|:.|.:.:::::..|:.................:|.||:|.|:.:
Human   999 QEVVLVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAE-- 1061

  Fly   843 LNSLAKHELYFENYRMVSVMFAMLINF--------EMDLRSLRVLNEIIAEFDTLLLFYKEYYTV 899
              .|...:.|.:|:....|:||.::||        |......|||||:|.:||. ||...:|.::
Human  1062 --QLKVSQTYSKNHDSGGVIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDE-LLSKPDYSSI 1123

  Fly   900 EKIKIVGCTYMAACGLDLNFAGSTSTNRKESIPPTEFNEEQSRRILFQQSNEDLDEVVFVMTSYA 964
            ||||.:|.|||||.||      :|:..:..|.|      ::..:|||:               :|
Human  1124 EKIKTIGATYMAASGL------NTAQAQDGSHP------QEHLQILFE---------------FA 1161

  Fly   965 LDMMRTLAKSNEAYQSIAGDRNIT--DGTIAIGISSGEVMAGIVGASQPHYDIWGNPVNMASRME 1027
            .:|||.:...|         .|:.  :..:.:|.:.|.:.||::|.::..|||||:.||:||||:
Human  1162 KEMMRVVDDFN---------NNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMD 1217

  Fly  1028 STGLPGHIHVTEETSEILQQFGITCSYRGMTFVKGRGKIPTYLVGIDENLNFIPQ---------- 1082
            :||:...|.|:||:..:|.:.|....|||...|||:|::.|||.....:...|||
Human  1218 TTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPKCTDHRVIPQHQLSISPDIR 1282

  Fly  1083 -----KATRFPSHQERSTVISLQSTYTHAENNNSIAST 1115
                 ...|.|:.:..:.|.|:|  |....:..|.:||
Human  1283 VQVDGSIGRSPTDEIANLVPSVQ--YVDKTSLGSDSST 1318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	59/273 (22%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	76/186 (41%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147	76/229 (33%)
ADCY9	XP_005255136.1	DUF2339	<118..>301	CDD:287113	42/203 (21%)
		CYCc	326..544	CDD:214485	79/222 (36%)
		Guanylate_cyc	385..573	CDD:278633	75/192 (39%)
		CYCc	1043..1243	CDD:214485	73/240 (30%)
		Guanylate_cyc	1069..1260	CDD:278633	75/227 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810