DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXE and Gucy2e

DIOPT Version :9

Sequence 1:	NP_652601.3	Gene:	ACXE / 53426	FlyBaseID:	FBgn0040506	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	NP_570093.2	Gene:	Gucy2e / 113911	RGDID:	69322	Length:	1123	Species:	Rattus norvegicus

Alignment Length:	966	Identity:	183/966 - (18%)
Similarity:	289/966 - (29%)	Gaps:	403/966 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   385 HGLDINMRIGVHSGNLFAGVIGEAKLQFDIWGLDVTIANV-------LESTGVPGCVHISGATLN 442
            |||.|.:...:..|.  .|.....|....:.||.:.:..:       ||.|.:..|....|.|..
  Rat   224 HGLPIGLITSLGPGE--KGATEVCKQLHSVHGLKIVVLCMHSALLGGLEQTVLLRCARKEGLTDG 286

  Fly   443 NLDVNRFDIEDGPEEARDHPLL--KKYRIRSYIIRQDLHMDDEDSDEFLGDLHSISL-------- 497
            .|....:|           .||  ..||.|||::..    ||....|....:.:|||
  Rat   287 RLVFLPYD-----------TLLFALPYRNRSYLVLD----DDGPLQEAYDAVLTISLDTSPESHA 336

  Fly   498 -----------CNMGAQP------RISDSANQSLRALFHEE----------LREEFRKMPVSAFS 535
                       .|:|.:.      .|.|:......||.|.|          |....|.:.|:.||
  Rat   337 FTATKMRGGTAANLGPEQVSPLFGTIYDAVILLAHALNHSEAHGTGLSGAHLGNHIRALDVAGFS 401

  Fly   536 PK-RLLGICRFNTGKEVPAHQNLNICLTFTDPILERAYLKQTDYMYKYSIILSASVGCSLVYIEL 599
            .: |:.|     .|:.:|                            :|.|:.:...|..||...:
  Rat   402 QRIRIDG-----KGRRLP----------------------------QYVILDTNGEGSQLVPTHI 433

  Fly   600 MD--TQMI-----------------CSSCFVLPASVA-------------TIQCILALIAWYKKY 632
            :|  ||.:                 .:||:..|.::.             ||.|:|||:..:..|
  Rat   434 LDVSTQQVQPLGTAVHFPGGSPPARDASCWFDPNTLCIRGVQPLGSLLTLTITCVLALVGGFLAY 498

  Fly   633 CWTRYGRNNV---------------------------PHHYNGF--------------------S 650
             :.|.|...:                           ||..:|.                    |
  Rat   499 -FIRLGLQQLRLLRGPHRILLTPQELTFLQRTPSRRRPHVDSGSESRSVVDGGSPQSVIQGSTRS 562

  Fly   651 CFIFRIHDKIL----------------------NSLPI----------RICIYLFLMISSFFVMC 683
            ...|..|..:.                      :||.:          .:..:|.|.:.. .|..
  Rat   563 VPAFLEHTNVALYQGEWVWLKKFEAGTAPDLRPSSLSLLRKMREMRHENVTAFLGLFVGP-EVSA 626

  Fly   684 LIVMSCQREEFE-------------------------MAYIEERLFHYEQ--------------- 708
            :::..|.|...|                         :.|:..|.|.:.:
  Rat   627 MVLEHCARGSLEDLLRNEDLRLDWTFKASLLLDLIRGLRYLHHRHFPHGRLKSRNCVVDTRFVLK 691

  Fly   709 ----------EAHICFHP--------WVTTNML-------------------SLMICLTFTFAHI 736
                      |:|..|.|        |....:|                   ||.|.|.......
  Rat   692 ITDHGYAEFLESHCSFRPQPAPEELLWTAPELLRGPRRPWGPGKATFKGDVFSLGIILQEVLTRD 756

  Fly   737 P-----------IMVKTA-------------VAILETLAYLLLIFFQ-------FDFVFHHSVTT 770
            |           |:.|.|             ...||.:..:.|.:.:       .|.::....:.
  Rat   757 PPYCSWGLSAEEIIRKVASPPPLCRPLVSPDQGPLECIQLMQLCWEEAPDDRPSLDQIYTQFKSI 821

  Fly   771 NPYFKSEYAHALLICI----TFLIMFVKERQIEFTNKVNFNWRVDLRKEENAASLTNHSIIIILN 831
            |...|:..|.::|..:    ..|...|:||..|.        .::.||.|.           :|:
  Rat   822 NQGKKTSVADSMLRMLEKYSQSLEGLVQERTEEL--------ELERRKTER-----------LLS 867

  Fly   832 NILPSHIVDVYLNSLAKHELYFENYRMVSVMFAMLINF------EMDLRSLRVLNEIIAEFDTLL 890
            .:||..:.............||:   .|::.|:.::.|      ...:..:..||::...||.:|
  Rat   868 QMLPPSVAHALKMGTTVEPEYFD---QVTIYFSDIVGFTTISALSEPIEVVGFLNDLYTMFDAVL 929

  Fly   891 LFYKEYYTVEKIKIVGCTYMAACGLDLNFAGSTSTNRKESIPPTEFNEEQSRRILFQQSNEDLDE 955
                :.:.|.|::.:|..||.|.||                         .||    ..|....|
  Rat   930 ----DSHDVYKVETIGDAYMVASGL-------------------------PRR----NGNRHAAE 961

  Fly   956 VVFVMTSYALDMMRTLAKSNEAYQSIAGD---RNITDGTIAI--GISSGEVMAGIVGASQPHYDI 1015
            :    .:.||:::           |.||:   |:..|..|.:  |:.||..:||:||.:.|.|.:
  Rat   962 I----ANMALEIL-----------SYAGNFRMRHAPDVPIRVRAGLHSGPCVAGVVGLTMPRYCL 1011

  Fly  1016 WGNPVNMASRMESTGLPGHIHVTEETSEILQQF--GITCSYRGMTFVKGRGKIPTY 1069
            :|:.||.||||||||||..|||:..|.:.|...  |.....||.|.:||:|...||
  Rat  1012 FGDTVNTASRMESTGLPYRIHVSRNTVQALLSLDEGYKIDVRGQTELKGKGLEETY 1067

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454
		Nucleotidyl_cyc_III	290..459	CDD:325147	17/80 (21%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147	66/232 (28%)
Gucy2e	NP_570093.2	PBP1_sensory_GC_DEF-like	71..445	CDD:380594	55/270 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	529..556		3/26 (12%)
		PK_GC-2D	554..824	CDD:270945	33/270 (12%)
		CYCc	861..1050	CDD:214485	63/250 (25%)
		Interaction with NCALD. /evidence=ECO:0000269\|PubMed:18178149	880..921		7/43 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900