Protein Alignment ACXE and ADCY6

DIOPT Version :9

• Sequence 1: NP_652601.3
• Gene: ACXE / 53426
• FlyBaseID: FBgn0040506
• Length: 1123
• Species: Drosophila melanogaster
• Sequence 2: NP_001377760.1
• Gene: ADCY6 / 112
• HGNCID: 237
• Length: 1168
• Species: Homo sapiens
• Alignment Length: 1174
• Identity: 323/1174 - (27%)
• Similarity: 541/1174 - (46%)
• Gaps: 225/1174 - (19%)

  Fly     1 MPRSLGNC-----QLNYSKERMWEPGYLKAKCAELRLESEFRLYRIRLWKSYLLTFFMLHIFVTS 60
            :|||..:|     |:..||:      :..||     ||..::.|..::.:|.|.....:.:.:|:
Human   111 VPRSGRSCWRRLVQVFQSKQ------FRSAK-----LERLYQRYFFQMNQSSLTLLMAVLVLLTA 164

  Fly    61 VHCALLLATIERRSIIYFDVALSIGCALVLILVLSVNFCDEFIAKHTW---YMYASSIFASLTLV 122
            |..|...|. .|....|  ||| :.||..|.:.|.| .|:    :|::   .|:..| :..|.::
Human   165 VLLAFHAAP-ARPQPAY--VAL-LACAAALFVGLMV-VCN----RHSFRQDSMWVVS-YVVLGIL 219

  Fly   123 FADLTESIYHTYAHSWILGTFYDTYIIYMIYMFLPIHFISGAVLLALLVSGLYILYFVIF--IAQ 185
            .|............|...|.:...:.:|:.|..|||. :..|||..|   ||..|:.::.  :.:
Human   220 AAVQVGGALAADPRSPSAGLWCPVFFVYIAYTLLPIR-MRAAVLSGL---GLSTLHLILAWQLNR 280

  Fly   186 GFAQFASALFSVGGMSVDIVHYLCLNLVGIFYRVMNDTVVRSSFLDRHQYIKEKIWLRNARLQEK 250
            |.|      |....:..:::.:||.|::||......:...|.:|.:...||:.::.|::...|::
Human   281 GDA------FLWKQLGANVLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQE 339

  Fly   251 QLLDSILPPQISLPLQKDIQGRIVMAKQGIHSWTAMERTMAIQIHPDVSILYADVVNYTHLTTTL 315
            :||.|:||..:::.:::||..:    |:.:     |...:.||.|.:||||:||:..:|.|.:..
Human   340 RLLLSVLPQHVAMEMKEDINTK----KEDM-----MFHKIYIQKHDNVSILFADIEGFTSLASQC 395

  Fly   316 TVEMLVKVLHDLYGRFDLAAYRYKVQRIKFLGDCYYCVAGLSDPDPDHANNCVILGLSMINHIME 380
            |.:.||..|::|:.|||..|......|||.||||||||:||.:...|||:.||.:|:.||..|..
Human   396 TAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISL 460

  Fly   381 VRDIHGLDINMRIGVHSGNLFAGVIGEAKLQFDIWGLDVTIANVLESTGVPGCVHISGATLNNLD 445
            ||::.|:::|||:|:|||.:..||:|..|.|||:|..|||:||.:|:.|..|.:||:.|||..|:
Human   461 VREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLN 525

  Fly   446 VNRFDIEDGPEEARDHPLLKKYRIRSYIIRQDLHMDDEDSDE--FLGDLHSISLCNM-GAQPR-- 505
             ..:::|.|....| :..||:..|.:::|   |....:..:|  .|..|......:| |..||
Human   526 -GDYEVEPGRGGER-NAYLKEQHIETFLI---LGASQKRKEEKAMLAKLQRTRANSMEGLMPRWV 585

  Fly   506 ------------------ISDSA--NQSLR-ALFHEELREEFRKMPVSAFSPKRLL--GICRFNT 547
                              |.||:  |:..: ||..|:..:||....:.|.|..:|.  .:.||
Human   586 PDRAFSRTKDSKAFRQMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRF-- 648

  Fly   548 GKEVPAHQNLNICLTFTDPILERAYLKQTDYMYKYSIILSASVGCSLVYIELM----DTQM--IC 606
                        .|||....||:.|.::.|..:...:..:..|.|.:.:|:|:    .|.|  |.
Human   649 ------------LLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIY 701

  Fly   607 SSCFVLPASVATIQCILALIAWYKKYCWTRYGRNNVPHHYNGFSCFIFRIHDKIL---------- 661
            :|.|:|......|..:.:..:.:.| ...|..|:.|....:..:..||.:   :|
Human   702 ASIFLLLLITVLICAVYSCGSLFPK-ALQRLSRSIVRSRAHSTAVGIFSV---LLVFTSAIANMF 762

  Fly   662 --NSLPIRICIYLFLMISSFFVMCLIVMSCQREEFEMAYIEERLFHYEQEAHIC--------FHP 716
              |..|||.|....|.::.             .:....::::..:....:|.:|        |..
Human   763 TCNHTPIRSCAARMLNLTP-------------ADITACHLQQLNYSLGLDAPLCEGTMPTCSFPE 814

  Fly   717 WVTTNMLSLMICLTFTFAHIPIMVKTAVAILETLAYLLL--------IFFQFDFVF--HHSVTTN 771
            :...||| |.:..:..|.||..:.|.|:..:..|.||:|        ||..:|.:.  |...::|
Human   815 YFIGNML-LSLLASSVFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSN 878

  Fly   772 PYFKS-----------EYAHALLICITFLIMFVKERQIEFTNKVNFNWRVDLRKEENAASLTNHS 825
            ..|..           :|...:::.:..|.:::..:|:|.|.:::|.|::....|:.........
Human   879 ETFDGLDCPAAGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAY 943

  Fly   826 IIIILNNILPSHIVDVYLNSLAKH----ELYFENYRMVSVMFAMLINF-----EMD-----LRSL 876
            ...:|:||||.   ||..:.||:.    |||:::...|:||||.:.||     |::     :..|
Human   944 NRRLLHNILPK---DVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECL 1005

  Fly   877 RVLNEIIAEFDTLLLFYKEYYTVEKIKIVGCTYMAACGLDLNFAGSTSTNRKESIPPTEFNEEQS 941
            |:||||||:||. ::..:.:..:||||.:|.|||||.||      :.||
Human  1006 RLLNEIIADFDE-IISEERFRQLEKIKTIGSTYMAASGL------NAST---------------- 1047

  Fly   942 RRILFQQSNEDLDEV----VFVMTSYALDMMRTLAKSNEAYQSIAGDRNITDGTIAIGISSGEVM 1002
                       .|:|    :..:..||:.:|..:...||        .:..:..:.||::.|.|:
Human  1048 -----------YDQVGRSHITALADYAMRLMEQMKHINE--------HSFNNFQMKIGLNMGPVV 1093

  Fly  1003 AGIVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTEETSEILQQFGITCSYRGMTFVKGRGKIP 1067
            ||::||.:|.||||||.||::|||:|||:|..|.||.:..::|...|.....||:..|||:|::.
Human  1094 AGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMT 1158

  Fly  1068 TYLV 1071
            ||.:
Human  1159 TYFL 1162

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	60/245 (24%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	76/168 (45%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147	78/233 (33%)
ADCY6	NP_001377760.1	AC_N	<16..368	CDD:318454	71/296 (24%)
		Guanylate_cyc	370..554	CDD:306677	81/188 (43%)
		DUF1053	582..668	CDD:399378	23/99 (23%)
		Guanylate_cyc	970..1164	CDD:306677	78/235 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910