Protein Alignment ACXE and ADCY5

DIOPT Version :10

• Sequence 1: NP_652601.3
• Gene: ACXE / 53426
• FlyBaseID: FBgn0040506
• Length: 1123
• Species: Drosophila melanogaster
• Sequence 2: NP_001365188.1
• Gene: ADCY5 / 111
• HGNCID: 236
• Length: 1286
• Species: Homo sapiens
• Alignment Length: 1210
• Identity: 317/1210 - (26%)
• Similarity: 533/1210 - (44%)
• Gaps: 276/1210 - (22%)

  Fly     4 SLGNC-----QLNYSKERMWEPGYLKAKCAELRLESEFRLYRIRLWKSYLLTFFMLHIFVTSVHC 63
            |||.|     |:..||           |....:||..::.|..||.:|.|.....:.:.|    |
Human   204 SLGACCLALLQIFRSK-----------KFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLV----C 253

  Fly    64 ALLLATIERRSIIYFDVALSIGCALVLILVLSVNFCDEFIAKHTWYMYASSIFASLTLVFADLTE 128
            .::||....|..:.......:..|:.:||:::| .|:. .|.|..:| ..:.:|.:.:|.|....
Human   254 LVMLAFHAARPPLQLPYLAVLAAAVGVILIMAV-LCNR-AAFHQDHM-GLACYALIAVVLAVQVV 315

  Fly   129 SIYHTYAHSWILGTFYDTYIIYMIYMFLPIHFISGAVLLALLVSGLYILYFVIFIAQGFAQFASA 193
            .:......|...|.::..:.||.||..||:. :..|||..:|:|.|:       :|......|..
Human   316 GLLLPQPRSASEGIWWTVFFIYTIYTLLPVR-MRAAVLSGVLLSALH-------LAIALRTNAQD 372

  Fly   194 LFSVGGMSVDIVHYLCLNLVGIFYRVMNDTVVRSSFLDRHQYIKEKIWLRNARLQEKQLLDSILP 258
            .|.:..:..:::.:.|.|:||:......:...|.:|.:..:.|:.::..:....|:::||.|:||
Human   373 QFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLP 437

  Fly   259 PQISLPLQKDIQGRIVMAKQGIHSWTAMERTMAIQIHPDVSILYADVVNYTHLTTTLTVEMLVKV 323
            ..:::.::.||.     |||.    ..|...:.||.|.:||||:||:..:|.|.:..|.:.||..
Human   438 RHVAMEMKADIN-----AKQE----DMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMT 493

  Fly   324 LHDLYGRFDLAAYRYKVQRIKFLGDCYYCVAGLSDPDPDHANNCVILGLSMINHIMEVRDIHGLD 388
            |::|:.|||..|......|||.||||||||:||.:...|||:.||.:|:.||..|..||::.|::
Human   494 LNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVN 558

  Fly   389 INMRIGVHSGNLFAGVIGEAKLQFDIWGLDVTIANVLESTGVPGCVHISGATLNNLDVNRFDIED 453
            :|||:|:|||.:..||:|..|.|||:|..|||:||.:|:.|..|.:||:.||||.|: ..:::|.
Human   559 VNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLN-GDYEVEP 622

  Fly   454 GPEEARDHPLLKKYRIRSYIIRQDLHMDDEDS----------------------------DEFLG 490
            |....| :..||::.|.:::|.:......|:.                            :...|
Human   623 GCGGER-NAYLKEHSIETFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGG 686

  Fly   491 DLHSISLCNMGAQPRISDSANQSLRALFHEELREEFRKMPVSAFSPKRLLG--ICRFNTGKEVPA 553
            :..|..:..||.:.....:|.:|...   |:..:||....:.|.|..||..  :.:|
Human   687 NQVSKEMKRMGFEDPKDKNAQESANP---EDEVDEFLGRAIDARSIDRLRSEHVRKF-------- 740

  Fly   554 HQNLNICLTFTDPILERAYLKQTDYMYKYSIILSASVGC-SLVYIELMDTQMICSSCFV----LP 613
                  .|||.:|.||:.|.||.|..:      .|.|.| |||::.:         |||    :|
Human   741 ------LLTFREPDLEKKYSKQVDDRF------GAYVACASLVFLFI---------CFVQITIVP 784

  Fly   614 ASV------ATIQCILALIAWYKKYCWTRYGRNNVPHHYNGFSCF-IF---------RIHDKILN 662
            .|:      .|...:|.|:.:....                :||. :|         :|....:|
Human   785 HSIFMLSFYLTCSLLLTLVVFVSVI----------------YSCVKLFPSPLQTLSRKIVRSKMN 833

  Fly   663 SLPIRI----CIYLFLMISSFFVMCLIVMSCQREEFEMA-------YIEERLFHYE--QEAHICF 714
            |..:.:    .::|...::.|......::.|..:|..::       ::.|...:|.  .|...|.
Human   834 STLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCG 898

  Fly   715 HPWVTTN---------MLSLMICLTFTFAHIPIMVKTAVAILETLAYLLLI-------------- 756
            .||...|         :|||:.|  ..|..|..:.|..:.:...|.|:|::
Human   899 SPWPNCNFPEYFTYSVLLSLLAC--SVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADLL 961

  Fly   757 -------FFQ--------FDFVFHHSVTTNPYFKS-------EYA--------HALLICITFLIM 791
                   ||.        .:.:.|..:....||.|       |:|        ..::|.:..|.:
Human   962 VTANAIDFFNNGTSQWSLCENLRHRRMEAGTYFPSGVKEQSPEHATKVALKVVTPIIISVFVLAL 1026

  Fly   792 FVKERQIEFTNKVNFNWRVDLRKEENAASLTNHSIIIILNNILPSHIVDVYLNSLAKH----ELY 852
            ::..:|:|.|.:::|.|::...:|:............:|:||||.   ||..:.||:.    |||
Human  1027 YLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPK---DVAAHFLARERRNDELY 1088

  Fly   853 FENYRMVSVMFAMLINF-----EMD-----LRSLRVLNEIIAEFDTLLLFYKEYYTVEKIKIVGC 907
            :::...|:||||.:.||     |::     :..||:||||||:||. ::....:..:||||.:|.
Human  1089 YQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDE-IISEDRFRQLEKIKTIGS 1152

  Fly   908 TYMAACGLDLNFAGSTSTNRKESIPPTEFNEEQSRRILFQQSNEDLDEV----VFVMTSYALDMM 968
            |||||.||                                 ::...|:|    :..:..:|:.:|
Human  1153 TYMAASGL---------------------------------NDSTYDKVGKTHIKALADFAMKLM 1184

  Fly   969 RTLAKSNEAYQSIAGDRNITDGTIAIGISSGEVMAGIVGASQPHYDIWGNPVNMASRMESTGLPG 1033
            ..:...||        .:..:..:.||::.|.|:||::||.:|.||||||.||:||||:|||:|.
Human  1185 DQMKYINE--------HSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPD 1241

  Fly  1034 HIHVTEETSEIL--QQFGITCSYRGMTFVKGRGKIPTYLV 1071
            .|.||.:..::|  ..:.:.|  ||:..|||:|::.||.:
Human  1242 RIQVTTDMYQVLAANTYQLEC--RGVVKVKGKGEMMTYFL 1279

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AcyC	65..453	CDD:441717	125/387 (32%)
		Nucleotidyl_cyc_III	290..459	CDD:448371	77/168 (46%)
		Nucleotidyl_cyc_III	851..1071	CDD:448371	76/235 (32%)
ADCY5	NP_001365188.1	AC_N	1..458	CDD:318454	67/288 (23%)
		Guanylate_cyc	460..643	CDD:425528	81/184 (44%)
		Adcy_cons_dom	668..761	CDD:461877	24/109 (22%)
		Guanylate_cyc	1087..1281	CDD:425528	76/237 (32%)