DRSC/TRiP Functional Genomics Resources

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Protein Alignment ACXE and ADCY5

DIOPT Version :9

Sequence 1:NP_652601.3 Gene:ACXE / 53426 FlyBaseID:FBgn0040506 Length:1123 Species:Drosophila melanogaster
Sequence 2:NP_001365188.1 Gene:ADCY5 / 111 HGNCID:236 Length:1286 Species:Homo sapiens


Alignment Length:1210 Identity:317/1210 - (26%)
Similarity:533/1210 - (44%) Gaps:276/1210 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 SLGNC-----QLNYSKERMWEPGYLKAKCAELRLESEFRLYRIRLWKSYLLTFFMLHIFVTSVHC 63
            |||.|     |:..||           |....:||..::.|..||.:|.|.....:.:.|    |
Human   204 SLGACCLALLQIFRSK-----------KFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLV----C 253

  Fly    64 ALLLATIERRSIIYFDVALSIGCALVLILVLSVNFCDEFIAKHTWYMYASSIFASLTLVFADLTE 128
            .::||....|..:.......:..|:.:||:::| .|:. .|.|..:| ..:.:|.:.:|.|....
Human   254 LVMLAFHAARPPLQLPYLAVLAAAVGVILIMAV-LCNR-AAFHQDHM-GLACYALIAVVLAVQVV 315

  Fly   129 SIYHTYAHSWILGTFYDTYIIYMIYMFLPIHFISGAVLLALLVSGLYILYFVIFIAQGFAQFASA 193
            .:......|...|.::..:.||.||..||:. :..|||..:|:|.|:       :|......|..
Human   316 GLLLPQPRSASEGIWWTVFFIYTIYTLLPVR-MRAAVLSGVLLSALH-------LAIALRTNAQD 372

  Fly   194 LFSVGGMSVDIVHYLCLNLVGIFYRVMNDTVVRSSFLDRHQYIKEKIWLRNARLQEKQLLDSILP 258
            .|.:..:..:::.:.|.|:||:......:...|.:|.:..:.|:.::..:....|:::||.|:||
Human   373 QFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLP 437

  Fly   259 PQISLPLQKDIQGRIVMAKQGIHSWTAMERTMAIQIHPDVSILYADVVNYTHLTTTLTVEMLVKV 323
            ..:::.::.||.     |||.    ..|...:.||.|.:||||:||:..:|.|.:..|.:.||..
Human   438 RHVAMEMKADIN-----AKQE----DMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMT 493

  Fly   324 LHDLYGRFDLAAYRYKVQRIKFLGDCYYCVAGLSDPDPDHANNCVILGLSMINHIMEVRDIHGLD 388
            |::|:.|||..|......|||.||||||||:||.:...|||:.||.:|:.||..|..||::.|::
Human   494 LNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVN 558

  Fly   389 INMRIGVHSGNLFAGVIGEAKLQFDIWGLDVTIANVLESTGVPGCVHISGATLNNLDVNRFDIED 453
            :|||:|:|||.:..||:|..|.|||:|..|||:||.:|:.|..|.:||:.||||.|: ..:::|.
Human   559 VNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLN-GDYEVEP 622

  Fly   454 GPEEARDHPLLKKYRIRSYIIRQDLHMDDEDS----------------------------DEFLG 490
            |....| :..||::.|.:::|.:......|:.                            :...|
Human   623 GCGGER-NAYLKEHSIETFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGG 686

  Fly   491 DLHSISLCNMGAQPRISDSANQSLRALFHEELREEFRKMPVSAFSPKRLLG--ICRFNTGKEVPA 553
            :..|..:..||.:.....:|.:|...   |:..:||....:.|.|..||..  :.:|        
Human   687 NQVSKEMKRMGFEDPKDKNAQESANP---EDEVDEFLGRAIDARSIDRLRSEHVRKF-------- 740

  Fly   554 HQNLNICLTFTDPILERAYLKQTDYMYKYSIILSASVGC-SLVYIELMDTQMICSSCFV----LP 613
                  .|||.:|.||:.|.||.|..:      .|.|.| |||::.:         |||    :|
Human   741 ------LLTFREPDLEKKYSKQVDDRF------GAYVACASLVFLFI---------CFVQITIVP 784

  Fly   614 ASV------ATIQCILALIAWYKKYCWTRYGRNNVPHHYNGFSCF-IF---------RIHDKILN 662
            .|:      .|...:|.|:.:....                :||. :|         :|....:|
Human   785 HSIFMLSFYLTCSLLLTLVVFVSVI----------------YSCVKLFPSPLQTLSRKIVRSKMN 833

  Fly   663 SLPIRI----CIYLFLMISSFFVMCLIVMSCQREEFEMA-------YIEERLFHYE--QEAHICF 714
            |..:.:    .::|...::.|......::.|..:|..::       ::.|...:|.  .|...|.
Human   834 STLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCG 898

  Fly   715 HPWVTTN---------MLSLMICLTFTFAHIPIMVKTAVAILETLAYLLLI-------------- 756
            .||...|         :|||:.|  ..|..|..:.|..:.:...|.|:|::              
Human   899 SPWPNCNFPEYFTYSVLLSLLAC--SVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADLL 961

  Fly   757 -------FFQ--------FDFVFHHSVTTNPYFKS-------EYA--------HALLICITFLIM 791
                   ||.        .:.:.|..:....||.|       |:|        ..::|.:..|.:
Human   962 VTANAIDFFNNGTSQWSLCENLRHRRMEAGTYFPSGVKEQSPEHATKVALKVVTPIIISVFVLAL 1026

  Fly   792 FVKERQIEFTNKVNFNWRVDLRKEENAASLTNHSIIIILNNILPSHIVDVYLNSLAKH----ELY 852
            ::..:|:|.|.:::|.|::...:|:............:|:||||.   ||..:.||:.    |||
Human  1027 YLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPK---DVAAHFLARERRNDELY 1088

  Fly   853 FENYRMVSVMFAMLINF-----EMD-----LRSLRVLNEIIAEFDTLLLFYKEYYTVEKIKIVGC 907
            :::...|:||||.:.||     |::     :..||:||||||:||. ::....:..:||||.:|.
Human  1089 YQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDE-IISEDRFRQLEKIKTIGS 1152

  Fly   908 TYMAACGLDLNFAGSTSTNRKESIPPTEFNEEQSRRILFQQSNEDLDEV----VFVMTSYALDMM 968
            |||||.||                                 ::...|:|    :..:..:|:.:|
Human  1153 TYMAASGL---------------------------------NDSTYDKVGKTHIKALADFAMKLM 1184

  Fly   969 RTLAKSNEAYQSIAGDRNITDGTIAIGISSGEVMAGIVGASQPHYDIWGNPVNMASRMESTGLPG 1033
            ..:...||        .:..:..:.||::.|.|:||::||.:|.||||||.||:||||:|||:|.
Human  1185 DQMKYINE--------HSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPD 1241

  Fly  1034 HIHVTEETSEIL--QQFGITCSYRGMTFVKGRGKIPTYLV 1071
            .|.||.:..::|  ..:.:.|  ||:..|||:|::.||.:
Human  1242 RIQVTTDMYQVLAANTYQLEC--RGVVKVKGKGEMMTYFL 1279

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ACXENP_652601.3 AC_N <31..272 CDD:318454 55/240 (23%)
Nucleotidyl_cyc_III 290..459 CDD:325147 77/168 (46%)
Nucleotidyl_cyc_III 851..1071 CDD:325147 76/235 (32%)
ADCY5NP_001365188.1 AC_N 1..458 CDD:318454 67/288 (23%)
Guanylate_cyc 460..633 CDD:306677 78/174 (45%)
DUF1053 668..760 CDD:399378 24/108 (22%)
Guanylate_cyc 1087..1281 CDD:306677 76/237 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45627
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.910

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