Protein Alignment ACXE and ADCY3

DIOPT Version :10

• Sequence 1: NP_652601.3
• Gene: ACXE / 53426
• FlyBaseID: FBgn0040506
• Length: 1123
• Species: Drosophila melanogaster
• Sequence 2: XP_011530791.1
• Gene: ADCY3 / 109
• HGNCID: 234
• Length: 1186
• Species: Homo sapiens
• Alignment Length: 1308
• Identity: 332/1308 - (25%)
• Similarity: 549/1308 - (41%)
• Gaps: 344/1308 - (26%)

  Fly     1 MPRSLGNCQLNYSKERMWE------------------------------PGYLKAKCAELRLESE 35
            |||:.|..:..||.|...|                              |.:::.......||:.
Human     1 MPRNQGFSEPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSGSCLCLPRFMRLTFVPESLENL 65

  Fly    36 FRLYRIRLWKSYLL---TFFMLHIFVTSVHCALLLATIERRSIIYFDVALSIGCALVLILVLSVN 97
            ::.|..|.....||   .|..|......|.||::.::.:..|:.   ||   |..|||.::|.|
Human    66 YQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSSDKLASLA---VA---GIGLVLDIILFV- 123

  Fly    98 FCDEFIAKH----------TWYMYASSIFASLTLVFADLTESIYHTYAHSWILGTFYDTYIIYMI 152
            .|.:.:...          .|.:..:.||:.|.|.||       ..:|.|..:|  :..:.::..
Human   124 LCKKGLLPDRVTRRVLPYVLWLLITAQIFSYLGLNFA-------RAHAASDTVG--WQVFFVFSF 179

  Fly   153 YMFLPIHFISGAVLLALLVSGLYILYFVIFIAQGFAQFASALFSVGGMSVDIVHYLCLNLVGIFY 217
            ::.||:. :|..|:::::...::.|...:.:||...:....:..:..:..::..|||...|||..
Human   180 FITLPLS-LSPIVIISVVSCVVHTLVLGVTVAQQQQEELKGMQLLREILANVFLYLCAIAVGIMS 243

  Fly   218 RVMNDTVVRSSFLDRHQYIKEKIWLRNARLQEKQLLDSILPPQISLPLQKDIQGRIVMAKQGIHS 282
            ..|.|...|.:||:..|.::.|:.|.....|::.|:.||||..::..:.||      |.|.....
Human   244 YYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKD------MKKDESQK 302

  Fly   283 WTAMERTMAIQIHPDVSILYADVVNYTHLTTTLTVEMLVKVLHDLYGRFDLAAYRYKVQRIKFLG 347
            ......||.:..|.:||||:||:|.:|.|::..:.:.|||:|::|:.|||..|.:|...|||.||
Human   303 DQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILG 367

  Fly   348 DCYYCVAGLSDPDPDHANNCVILGLSMINHIMEVRDIHGLDINMRIGVHSGNLFAGVIGEAKLQF 412
            |||||:.||.|...|||...:::||:|:..|..||:.....::||:|||:|.:..||:|:.:.|:
Human   368 DCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQY 432

  Fly   413 DIWGLDVTIANVLESTGVPG----------C------------VHISGATLNNLDVNRFDIEDGP 455
            |:|..|||:||.:|:.|:||          |            ||||.:|::.|. ..||:|.|.
Human   433 DVWSTDVTVANKMEAGGIPGGSKIEERLYSCVVAPTLRLRWERVHISQSTMDCLK-GEFDVEPGD 496

  Fly   456 EEAR-DHPLLKKYRIRSYII------------------------------------------RQD 477
            ..:| |:  |::..|.:|:|                                          ...
Human   497 GGSRCDY--LEEKGIETYLIIASKPEVKKTATQNGLNGSALPNGAPASSKSSSPALIETKEPNGS 559

  Fly   478 LHM--------DDEDSDEFLGDLHSI--SLCNMGAQP------------RISDSANQ-------- 512
            .|.        :::|:..|...|..:  |.|..|:|.            |:.|.|::
Human   560 AHSSGSTSEKPEEQDAQLFPTTLSHLPHSRCLPGSQADNPSFPNPRRRLRLQDLADRVVDASEDE 624

  Fly   513 -SLRALFHEELREEFRKMPVSAFSPKRLLGICRFNTGKEVPAHQNLNICLTFTDPILERAYLKQT 576
             .|..|.:|.|.|.                    .:.:.|.......:.:.|.||.:|..|..:.
Human   625 HELNQLLNEALLER--------------------ESAQVVKKRNTFLLSMRFMDPEMETRYSVEK 669

  Fly   577 DYMYKYSIILSASVGCSLV-------------------YIELMDTQM------ICSSCFVLPASV 616
            :   |.|   .|:..||.|                   |:..|..::      |||...:.|.
Human   670 E---KQS---GAAFSCSCVVLLCTALVEILIDPWLMTNYVTFMVGEILLLILTICSLAAIFPR-- 726

  Fly   617 ATIQCILALIAWYKKYCWTRYGRNNVPHHYNGFSCFIFRIHDKILNSLPIRICIYLFLMISSF-F 680
            |..:.::|...|..:   ||:.||.                               :.|::.| .
Human   727 AFPKKLVAFSTWIDR---TRWARNT-------------------------------WAMLAIFIL 757

  Fly   681 VMCLIV--MSCQR-----------EEFEMAYIEE-RLFHYEQEAHICFHPWVTTNML---SLMIC 728
            ||..:|  :||.:           .|.|.:.:|. :.::|     :.....:.|.||   |.|:.
Human   758 VMANVVDMLSCLQYYTGPSNATAGMETEGSCLENPKYYNY-----VAVLSLIATIMLVQVSHMVK 817

  Fly   729 LTFTFAHIPIMVKTAVAILETLAYLLLIFFQFD---FVFHH------------------SVTTNP 772
            ||     :.::|..|||.:...|: ..:|.::|   |..|.                  :.:..|
Human   818 LT-----LMLLVAGAVATINLYAW-RPVFDEYDHKRFREHDLPMVALEQMQGFNPGLNGTDSRLP 876

  Fly   773 YFKSEYAHALLICITFLIMFVKERQIEFTNKVNFNWRVDLRKEENAASLTNHSIIIILNNILPSH 837
            ...|:|:..:::.:..|..:...|.:|...:..|.|::::..::............::.|:||.|
Human   877 LVPSKYSMTVMVFLMMLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEH 941

  Fly   838 IVDVYLNSLAK-HELYFENYRMVSVMFAMLINF----------EMDLRSLRVLNEIIAEFDTLLL 891
            :...:|.|..: .|||.:.|..:.||||.|.||          ...:..||.|||||::||: ||
Human   942 VARHFLGSKKRDEELYSQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDS-LL 1005

  Fly   892 FYKEYYTVEKIKIVGCTYMAACGL--DLNFAGSTSTNRKESIPPTEFNEEQSRRILFQQSNEDLD 954
            ...::..:.|||.:|.|||||.|:  |:|..|..|:|:          |::|.|..:|...:
Human  1006 DNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFASSNK----------EDKSERERWQHLAD--- 1057

  Fly   955 EVVFVMTSYALDMMRTLAKSNEAYQSIAGDRNITDGTIAIGISSGEVMAGIVGASQPHYDIWGNP 1019
                 :..:||.|..||...|        :::..:..:.||::.|.|:||::||.:||||||||.
Human  1058 -----LADFALAMKDTLTNIN--------NQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNT 1109

  Fly  1020 VNMASRMESTGLPGHIHVTEETSEILQQFGITCSYRGMTFVKGRGKIPT-YLVGIDENLNFIPQK 1083
            ||:||||||||:.|:|.|.|||..||:::|.....||..||||:|::.| :|.|.|:...|....
Human  1110 VNVASRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFLKGRDKLATFPNGP 1174

  Fly  1084 ATRFPSHQ 1091
            :...| ||
Human  1175 SVTLP-HQ 1181

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AcyC	65..453	CDD:441717	125/419 (30%)
		Nucleotidyl_cyc_III	290..459	CDD:448371	75/190 (39%)
		Nucleotidyl_cyc_III	851..1071	CDD:448371	89/232 (38%)
ADCY3	XP_011530791.1	AcyC	105..494	CDD:441717	125/412 (30%)
		Guanylate_cyc	310..516	CDD:425528	81/208 (39%)
		Guanylate_cyc	956..1163	CDD:425528	90/233 (39%)