DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ACXE and ADCY3

DIOPT Version :9

Sequence 1:NP_652601.3 Gene:ACXE / 53426 FlyBaseID:FBgn0040506 Length:1123 Species:Drosophila melanogaster
Sequence 2:XP_011530791.1 Gene:ADCY3 / 109 HGNCID:234 Length:1186 Species:Homo sapiens


Alignment Length:1308 Identity:332/1308 - (25%)
Similarity:549/1308 - (41%) Gaps:344/1308 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MPRSLGNCQLNYSKERMWE------------------------------PGYLKAKCAELRLESE 35
            |||:.|..:..||.|...|                              |.:::.......||:.
Human     1 MPRNQGFSEPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSGSCLCLPRFMRLTFVPESLENL 65

  Fly    36 FRLYRIRLWKSYLL---TFFMLHIFVTSVHCALLLATIERRSIIYFDVALSIGCALVLILVLSVN 97
            ::.|..|.....||   .|..|......|.||::.::.:..|:.   ||   |..|||.::|.| 
Human    66 YQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSSDKLASLA---VA---GIGLVLDIILFV- 123

  Fly    98 FCDEFIAKH----------TWYMYASSIFASLTLVFADLTESIYHTYAHSWILGTFYDTYIIYMI 152
            .|.:.:...          .|.:..:.||:.|.|.||       ..:|.|..:|  :..:.::..
Human   124 LCKKGLLPDRVTRRVLPYVLWLLITAQIFSYLGLNFA-------RAHAASDTVG--WQVFFVFSF 179

  Fly   153 YMFLPIHFISGAVLLALLVSGLYILYFVIFIAQGFAQFASALFSVGGMSVDIVHYLCLNLVGIFY 217
            ::.||:. :|..|:::::...::.|...:.:||...:....:..:..:..::..|||...|||..
Human   180 FITLPLS-LSPIVIISVVSCVVHTLVLGVTVAQQQQEELKGMQLLREILANVFLYLCAIAVGIMS 243

  Fly   218 RVMNDTVVRSSFLDRHQYIKEKIWLRNARLQEKQLLDSILPPQISLPLQKDIQGRIVMAKQGIHS 282
            ..|.|...|.:||:..|.::.|:.|.....|::.|:.||||..::..:.||      |.|.....
Human   244 YYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKD------MKKDESQK 302

  Fly   283 WTAMERTMAIQIHPDVSILYADVVNYTHLTTTLTVEMLVKVLHDLYGRFDLAAYRYKVQRIKFLG 347
            ......||.:..|.:||||:||:|.:|.|::..:.:.|||:|::|:.|||..|.:|...|||.||
Human   303 DQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILG 367

  Fly   348 DCYYCVAGLSDPDPDHANNCVILGLSMINHIMEVRDIHGLDINMRIGVHSGNLFAGVIGEAKLQF 412
            |||||:.||.|...|||...:::||:|:..|..||:.....::||:|||:|.:..||:|:.:.|:
Human   368 DCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQY 432

  Fly   413 DIWGLDVTIANVLESTGVPG----------C------------VHISGATLNNLDVNRFDIEDGP 455
            |:|..|||:||.:|:.|:||          |            ||||.:|::.|. ..||:|.|.
Human   433 DVWSTDVTVANKMEAGGIPGGSKIEERLYSCVVAPTLRLRWERVHISQSTMDCLK-GEFDVEPGD 496

  Fly   456 EEAR-DHPLLKKYRIRSYII------------------------------------------RQD 477
            ..:| |:  |::..|.:|:|                                          ...
Human   497 GGSRCDY--LEEKGIETYLIIASKPEVKKTATQNGLNGSALPNGAPASSKSSSPALIETKEPNGS 559

  Fly   478 LHM--------DDEDSDEFLGDLHSI--SLCNMGAQP------------RISDSANQ-------- 512
            .|.        :::|:..|...|..:  |.|..|:|.            |:.|.|::        
Human   560 AHSSGSTSEKPEEQDAQLFPTTLSHLPHSRCLPGSQADNPSFPNPRRRLRLQDLADRVVDASEDE 624

  Fly   513 -SLRALFHEELREEFRKMPVSAFSPKRLLGICRFNTGKEVPAHQNLNICLTFTDPILERAYLKQT 576
             .|..|.:|.|.|.                    .:.:.|.......:.:.|.||.:|..|..:.
Human   625 HELNQLLNEALLER--------------------ESAQVVKKRNTFLLSMRFMDPEMETRYSVEK 669

  Fly   577 DYMYKYSIILSASVGCSLV-------------------YIELMDTQM------ICSSCFVLPASV 616
            :   |.|   .|:..||.|                   |:..|..::      |||...:.|.  
Human   670 E---KQS---GAAFSCSCVVLLCTALVEILIDPWLMTNYVTFMVGEILLLILTICSLAAIFPR-- 726

  Fly   617 ATIQCILALIAWYKKYCWTRYGRNNVPHHYNGFSCFIFRIHDKILNSLPIRICIYLFLMISSF-F 680
            |..:.::|...|..:   ||:.||.                               :.|::.| .
Human   727 AFPKKLVAFSTWIDR---TRWARNT-------------------------------WAMLAIFIL 757

  Fly   681 VMCLIV--MSCQR-----------EEFEMAYIEE-RLFHYEQEAHICFHPWVTTNML---SLMIC 728
            ||..:|  :||.:           .|.|.:.:|. :.::|     :.....:.|.||   |.|:.
Human   758 VMANVVDMLSCLQYYTGPSNATAGMETEGSCLENPKYYNY-----VAVLSLIATIMLVQVSHMVK 817

  Fly   729 LTFTFAHIPIMVKTAVAILETLAYLLLIFFQFD---FVFHH------------------SVTTNP 772
            ||     :.::|..|||.:...|: ..:|.::|   |..|.                  :.:..|
Human   818 LT-----LMLLVAGAVATINLYAW-RPVFDEYDHKRFREHDLPMVALEQMQGFNPGLNGTDSRLP 876

  Fly   773 YFKSEYAHALLICITFLIMFVKERQIEFTNKVNFNWRVDLRKEENAASLTNHSIIIILNNILPSH 837
            ...|:|:..:::.:..|..:...|.:|...:..|.|::::..::............::.|:||.|
Human   877 LVPSKYSMTVMVFLMMLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEH 941

  Fly   838 IVDVYLNSLAK-HELYFENYRMVSVMFAMLINF----------EMDLRSLRVLNEIIAEFDTLLL 891
            :...:|.|..: .|||.:.|..:.||||.|.||          ...:..||.|||||::||: ||
Human   942 VARHFLGSKKRDEELYSQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDS-LL 1005

  Fly   892 FYKEYYTVEKIKIVGCTYMAACGL--DLNFAGSTSTNRKESIPPTEFNEEQSRRILFQQSNEDLD 954
            ...::..:.|||.:|.|||||.|:  |:|..|..|:|:          |::|.|..:|...:   
Human  1006 DNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFASSNK----------EDKSERERWQHLAD--- 1057

  Fly   955 EVVFVMTSYALDMMRTLAKSNEAYQSIAGDRNITDGTIAIGISSGEVMAGIVGASQPHYDIWGNP 1019
                 :..:||.|..||...|        :::..:..:.||::.|.|:||::||.:||||||||.
Human  1058 -----LADFALAMKDTLTNIN--------NQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNT 1109

  Fly  1020 VNMASRMESTGLPGHIHVTEETSEILQQFGITCSYRGMTFVKGRGKIPT-YLVGIDENLNFIPQK 1083
            ||:||||||||:.|:|.|.|||..||:::|.....||..||||:|::.| :|.|.|:...|....
Human  1110 VNVASRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFLKGRDKLATFPNGP 1174

  Fly  1084 ATRFPSHQ 1091
            :...| ||
Human  1175 SVTLP-HQ 1181

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ACXENP_652601.3 AC_N <31..272 CDD:318454 60/253 (24%)
Nucleotidyl_cyc_III 290..459 CDD:325147 75/190 (39%)
Nucleotidyl_cyc_III 851..1071 CDD:325147 89/232 (38%)
ADCY3XP_011530791.1 AC_N <44..303 CDD:292831 63/281 (22%)
CYCc 273..490 CDD:214485 82/223 (37%)
Guanylate_cyc 310..516 CDD:278633 81/208 (39%)
CYCc 925..1143 CDD:214485 88/244 (36%)
Guanylate_cyc 956..1163 CDD:278633 90/233 (39%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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