DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXE and Adcy3

DIOPT Version :9

Sequence 1:	NP_652601.3	Gene:	ACXE / 53426	FlyBaseID:	FBgn0040506	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	NP_612178.2	Gene:	Adcy3 / 104111	MGIID:	99675	Length:	1145	Species:	Mus musculus

Alignment Length:	1263	Identity:	316/1263 - (25%)
Similarity:	538/1263 - (42%)	Gaps:	295/1263 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPRSLGNCQLNYSKERMWE------------------------------PGYLKAKCAELRLESE 35
            |||:.|.....||.|...|                              |.:::.......||:.
Mouse     1 MPRNQGFSDPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSGSCLCLPRFMRLTFVPESLENL 65

  Fly    36 FRLYRIRLWKSYLLTFFMLHIFVTSVHCALLLATIERRSIIYFDVALS----IGCALVLILVLSV 96
            ::.|..|.....||   :|.:|.....|.:::..    ::::....|:    .|..|||.::|.|
Mouse    66 YQTYFKRQRHETLL---VLVVFAALFDCYVVVMC----AVVFSSDKLAPLMVAGFGLVLDIILFV 123

  Fly    97 NFCD----------EFIAKHTWYMYASSIFASLTLVFADLTESIYHTYAHSWILGTFYDTYIIYM 151
             .|.          :.:....|.:.::.||:.|.|.|:       ..:|.|..:|  :..:.::.
Mouse   124 -LCKKGLLPDRVSRKVVPYLLWLLISAQIFSYLGLNFS-------RAHAASDTVG--WQAFFVFS 178

  Fly   152 IYMFLPIHFISGAVLLALLVSGLYILYFVIFIAQGFAQFASALFSVGGMSVDIVHYLCLNLVGIF 216
            .::.||:. :|..|:::::...::.|...:.:||........:..:..:..::..|||..:|||.
Mouse   179 FFITLPLS-LSPIVIISVVSCVVHTLVLGVTVAQQQQDELEGMQLLREILANVFLYLCAIIVGIM 242

  Fly   217 YRVMNDTVVRSSFLDRHQYIKEKIWLRNARLQEKQLLDSILPPQISLPLQKDIQGRIVMAKQGIH 281
            ...|.|...|.:||:..|.::.|:.|.....|::.|:.||||..::..:.||      |.|....
Mouse   243 SYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKD------MKKDESQ 301

  Fly   282 SWTAMERTMAIQIHPDVSILYADVVNYTHLTTTLTVEMLVKVLHDLYGRFDLAAYRYKVQRIKFL 346
            .......||.:..|.:||||:||:|.:|.|::..:.:.|||:|::|:.|||..|.:|...|||.|
Mouse   302 KDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKIL 366

  Fly   347 GDCYYCVAGLSDPDPDHANNCVILGLSMINHIMEVRDIHGLDINMRIGVHSGNLFAGVIGEAKLQ 411
            ||||||:.||.|...|||...:::||:|:..|..||:.....::||:|||:|.:..||:|:.:.|
Mouse   367 GDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQ 431

  Fly   412 FDIWGLDVTIANVLESTGVPGCVHISGATLNNLDVNRFDIEDGPEEAR-DHPLLKKYRIRSYII- 474
            :|:|..|||:||.:|:.|:||.||||.:|::.|. ..||:|.|...:| |:  |.:..|.:|:|
Mouse   432 YDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLK-GEFDVEPGDGGSRCDY--LDEKGIETYLII 493

  Fly   475 ----------------------------------------RQDLHMD---DEDSDEFLGDLHSIS 496
                                                    ....|..   .|:::|......:.|
Mouse   494 ASKPEVKKTAQNGLNGSAVPNGAPASSKPSSPALIETKEPNGSAHASGSTSEEAEEQEAQADNPS 558

  Fly   497 LCNMGAQPRISDSANQ---------SLRALFHEELREEFRKMPVSAFSPKRLLGICRFNTGKEVP 552
            ..|...:.|:.|.|::         .|..|.:|.|.|.                    .:.:.|.
Mouse   559 FPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLER--------------------ESAQVVK 603

  Fly   553 AHQNLNICLTFTDPILERAYL----KQTDYMYKYSIILSASVGCSLVYIELMDTQM--------- 604
            ......:.:.|.||.:|..|.    ||:...:..|.::   :.|:.:...|:|..:
Mouse   604 KRNTFLLTMRFMDPEMETRYSVEKEKQSGAAFSCSCVV---LFCTAMVEILIDPWLMTNYVTFVV 665

  Fly   605 ---------ICSSCFVLPASVATIQCILALIAWYKKYCWTRYGRNNVPHHYNGFSCFIFRIHDKI 660
                     |||...:.|.|..  :.::|..:|..:   ||:.||.
Mouse   666 GEVLLLILTICSMAAIFPRSFP--KKLVAFSSWIDR---TRWARNT------------------- 706

  Fly   661 LNSLPIRICIYLFLMISSF-FVMCLIV--MSCQREEFEMAYIEERLFHYEQEAHI-----CF-HP 716
                        :.|::.| .||..:|  :||         ::..:..|...|.:     |. :|
Mouse   707 ------------WAMLAIFILVMANVVDMLSC---------LQYYMGPYNMTAGMELDGGCMENP 750

  Fly   717 WVTTNMLSLMICLTFTFAHIPIMVKTAVAILETLAYLLL-------IFFQFDFV----------- 763
            .....:..|.:..|.....:..|||..:.:|.|.|...|       :|.::|..
Mouse   751 KYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVTGAVTALNLYAWCPVFDEYDHKRFQEKDSPMVA 815

  Fly   764 -----------FHHSVTTNPYFKSEYAHALLICITFLIMFVKERQIEFTNKVNFNWRVDLRKEEN 817
                       .:.:.:..|...|:|:..:::.:..|..:...|.:|...:..|.|::::..::.
Mouse   816 LEKMQVLATPGLNGTDSRLPLVPSKYSMTVMMFVMMLSFYYFSRHVEKLARTLFLWKIEVHDQKE 880

  Fly   818 AASLTNHSIIIILNNILPSHIVDVYLNSLAK-HELYFENYRMVSVMFAMLINF----------EM 871
            ...........::.|:||.|:...:|.|..: .|||.::|..:.||||.|.||          ..
Mouse   881 RVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQSYDEIGVMFASLPNFADFYTEESINNG 945

  Fly   872 DLRSLRVLNEIIAEFDTLLLFYKEYYTVEKIKIVGCTYMAACGL--DLNFAGSTSTNRKESIPPT 934
            .:..||.|||||::||: ||...::..:.|||.:|.|||||.|:  |:|..|.||:::
Mouse   946 GIECLRFLNEIISDFDS-LLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFTSSSK------- 1002

  Fly   935 EFNEEQSRRILFQQSNEDLDEVVFVMTSYALDMMRTLAKSNEAYQSIAGDRNITDGTIAIGISSG 999
               ||:|.:..:|...:        :..:||.|..||...|        :::..:..:.||::.|
Mouse  1003 ---EEKSDKERWQHLAD--------LADFALAMKDTLTNIN--------NQSFNNFMLRIGMNKG 1048

  Fly  1000 EVMAGIVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTEETSEILQQFGITCSYRGMTFVKGRG 1064
            .|:||::||.:||||||||.||:||||||||:.|:|.|.|||..||:::|.....||..||||:|
Mouse  1049 GVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKG 1113

  Fly  1065 KIPT-YLVGIDENLNFIPQKATRFPSHQ 1091
            ::.| :|.|.|....|....:...| ||
Mouse  1114 ELLTFFLKGRDRPAAFPNGSSVTLP-HQ 1140

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	55/254 (22%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	74/168 (44%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147	89/232 (38%)
Adcy3	NP_612178.2	AC_N	<44..303	CDD:318454	58/282 (21%)
		Guanylate_cyc	310..494	CDD:306677	80/186 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	504..564		5/59 (8%)
		Guanylate_cyc	915..1122	CDD:306677	90/233 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810