Protein Alignment ACXE and Adcy3

DIOPT Version :10

• Sequence 1: NP_652601.3
• Gene: ACXE / 53426
• FlyBaseID: FBgn0040506
• Length: 1123
• Species: Drosophila melanogaster
• Sequence 2: NP_612178.2
• Gene: Adcy3 / 104111
• MGIID: 99675
• Length: 1145
• Species: Mus musculus
• Alignment Length: 1263
• Identity: 316/1263 - (25%)
• Similarity: 538/1263 - (42%)
• Gaps: 295/1263 - (23%)

  Fly     1 MPRSLGNCQLNYSKERMWE------------------------------PGYLKAKCAELRLESE 35
            |||:.|.....||.|...|                              |.:::.......||:.
Mouse     1 MPRNQGFSDPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSGSCLCLPRFMRLTFVPESLENL 65

  Fly    36 FRLYRIRLWKSYLLTFFMLHIFVTSVHCALLLATIERRSIIYFDVALS----IGCALVLILVLSV 96
            ::.|..|.....||   :|.:|.....|.:::..    ::::....|:    .|..|||.::|.|
Mouse    66 YQTYFKRQRHETLL---VLVVFAALFDCYVVVMC----AVVFSSDKLAPLMVAGFGLVLDIILFV 123

  Fly    97 NFCD----------EFIAKHTWYMYASSIFASLTLVFADLTESIYHTYAHSWILGTFYDTYIIYM 151
             .|.          :.:....|.:.::.||:.|.|.|:       ..:|.|..:|  :..:.::.
Mouse   124 -LCKKGLLPDRVSRKVVPYLLWLLISAQIFSYLGLNFS-------RAHAASDTVG--WQAFFVFS 178

  Fly   152 IYMFLPIHFISGAVLLALLVSGLYILYFVIFIAQGFAQFASALFSVGGMSVDIVHYLCLNLVGIF 216
            .::.||:. :|..|:::::...::.|...:.:||........:..:..:..::..|||..:|||.
Mouse   179 FFITLPLS-LSPIVIISVVSCVVHTLVLGVTVAQQQQDELEGMQLLREILANVFLYLCAIIVGIM 242

  Fly   217 YRVMNDTVVRSSFLDRHQYIKEKIWLRNARLQEKQLLDSILPPQISLPLQKDIQGRIVMAKQGIH 281
            ...|.|...|.:||:..|.::.|:.|.....|::.|:.||||..::..:.||      |.|....
Mouse   243 SYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKD------MKKDESQ 301

  Fly   282 SWTAMERTMAIQIHPDVSILYADVVNYTHLTTTLTVEMLVKVLHDLYGRFDLAAYRYKVQRIKFL 346
            .......||.:..|.:||||:||:|.:|.|::..:.:.|||:|::|:.|||..|.:|...|||.|
Mouse   302 KDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKIL 366

  Fly   347 GDCYYCVAGLSDPDPDHANNCVILGLSMINHIMEVRDIHGLDINMRIGVHSGNLFAGVIGEAKLQ 411
            ||||||:.||.|...|||...:::||:|:..|..||:.....::||:|||:|.:..||:|:.:.|
Mouse   367 GDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQ 431

  Fly   412 FDIWGLDVTIANVLESTGVPGCVHISGATLNNLDVNRFDIEDGPEEAR-DHPLLKKYRIRSYII- 474
            :|:|..|||:||.:|:.|:||.||||.:|::.|. ..||:|.|...:| |:  |.:..|.:|:|
Mouse   432 YDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLK-GEFDVEPGDGGSRCDY--LDEKGIETYLII 493

  Fly   475 ----------------------------------------RQDLHMD---DEDSDEFLGDLHSIS 496
                                                    ....|..   .|:::|......:.|
Mouse   494 ASKPEVKKTAQNGLNGSAVPNGAPASSKPSSPALIETKEPNGSAHASGSTSEEAEEQEAQADNPS 558

  Fly   497 LCNMGAQPRISDSANQ---------SLRALFHEELREEFRKMPVSAFSPKRLLGICRFNTGKEVP 552
            ..|...:.|:.|.|::         .|..|.:|.|.|.                    .:.:.|.
Mouse   559 FPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLER--------------------ESAQVVK 603

  Fly   553 AHQNLNICLTFTDPILERAYL----KQTDYMYKYSIILSASVGCSLVYIELMDTQM--------- 604
            ......:.:.|.||.:|..|.    ||:...:..|.::   :.|:.:...|:|..:
Mouse   604 KRNTFLLTMRFMDPEMETRYSVEKEKQSGAAFSCSCVV---LFCTAMVEILIDPWLMTNYVTFVV 665

  Fly   605 ---------ICSSCFVLPASVATIQCILALIAWYKKYCWTRYGRNNVPHHYNGFSCFIFRIHDKI 660
                     |||...:.|.|..  :.::|..:|..:   ||:.||.
Mouse   666 GEVLLLILTICSMAAIFPRSFP--KKLVAFSSWIDR---TRWARNT------------------- 706

  Fly   661 LNSLPIRICIYLFLMISSF-FVMCLIV--MSCQREEFEMAYIEERLFHYEQEAHI-----CF-HP 716
                        :.|::.| .||..:|  :||         ::..:..|...|.:     |. :|
Mouse   707 ------------WAMLAIFILVMANVVDMLSC---------LQYYMGPYNMTAGMELDGGCMENP 750

  Fly   717 WVTTNMLSLMICLTFTFAHIPIMVKTAVAILETLAYLLL-------IFFQFDFV----------- 763
            .....:..|.:..|.....:..|||..:.:|.|.|...|       :|.::|..
Mouse   751 KYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVTGAVTALNLYAWCPVFDEYDHKRFQEKDSPMVA 815

  Fly   764 -----------FHHSVTTNPYFKSEYAHALLICITFLIMFVKERQIEFTNKVNFNWRVDLRKEEN 817
                       .:.:.:..|...|:|:..:::.:..|..:...|.:|...:..|.|::::..::.
Mouse   816 LEKMQVLATPGLNGTDSRLPLVPSKYSMTVMMFVMMLSFYYFSRHVEKLARTLFLWKIEVHDQKE 880

  Fly   818 AASLTNHSIIIILNNILPSHIVDVYLNSLAK-HELYFENYRMVSVMFAMLINF----------EM 871
            ...........::.|:||.|:...:|.|..: .|||.::|..:.||||.|.||          ..
Mouse   881 RVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQSYDEIGVMFASLPNFADFYTEESINNG 945

  Fly   872 DLRSLRVLNEIIAEFDTLLLFYKEYYTVEKIKIVGCTYMAACGL--DLNFAGSTSTNRKESIPPT 934
            .:..||.|||||::||: ||...::..:.|||.:|.|||||.|:  |:|..|.||:::
Mouse   946 GIECLRFLNEIISDFDS-LLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFTSSSK------- 1002

  Fly   935 EFNEEQSRRILFQQSNEDLDEVVFVMTSYALDMMRTLAKSNEAYQSIAGDRNITDGTIAIGISSG 999
               ||:|.:..:|...:        :..:||.|..||...|        :::..:..:.||::.|
Mouse  1003 ---EEKSDKERWQHLAD--------LADFALAMKDTLTNIN--------NQSFNNFMLRIGMNKG 1048

  Fly  1000 EVMAGIVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTEETSEILQQFGITCSYRGMTFVKGRG 1064
            .|:||::||.:||||||||.||:||||||||:.|:|.|.|||..||:::|.....||..||||:|
Mouse  1049 GVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKG 1113

  Fly  1065 KIPT-YLVGIDENLNFIPQKATRFPSHQ 1091
            ::.| :|.|.|....|....:...| ||
Mouse  1114 ELLTFFLKGRDRPAAFPNGSSVTLP-HQ 1140

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AcyC	65..453	CDD:441717	121/401 (30%)
		Nucleotidyl_cyc_III	290..459	CDD:448371	74/168 (44%)
		Nucleotidyl_cyc_III	851..1071	CDD:448371	89/232 (38%)
Adcy3	NP_612178.2	AcyC	105..499	CDD:441717	129/413 (31%)
		Guanylate_cyc	310..494	CDD:425528	80/186 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	504..564		5/59 (8%)
		Guanylate_cyc	915..1122	CDD:425528	90/233 (39%)