DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ACXE and Adcy4

DIOPT Version :9

Sequence 1:NP_652601.3 Gene:ACXE / 53426 FlyBaseID:FBgn0040506 Length:1123 Species:Drosophila melanogaster
Sequence 2:NP_001348533.1 Gene:Adcy4 / 104110 MGIID:99674 Length:1077 Species:Mus musculus


Alignment Length:1112 Identity:311/1112 - (27%)
Similarity:498/1112 - (44%) Gaps:199/1112 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    57 FVTSVHCA-----LLLATIERRSIIYFDVALSIGCALVLILVLSVNFCDEFIAKHTWYMYASSIF 116
            |:|:|.||     |||....|...:........|...|.:|.|...|           ::...:.
Mouse    61 FLTTVLCALGGFSLLLGLASREQQLQRWTRPLSGLIWVALLALGYGF-----------LFTGGVV 114

  Fly   117 ASLTLVFADLTESIYHTYAHSWILGTFYDTYIIYMIYMFLPIHFISGAV------LLALLVSGLY 175
            :                   :|...:|: .:||:.:|..||:.....|.      |..|||.|||
Mouse   115 S-------------------AWDQVSFF-LFIIFTVYAMLPLGMRDAAAAGVISSLSHLLVLGLY 159

  Fly   176 ILYFVIFIAQGFAQFASALFSVGGMSVDIVHYLCLNLVGIFYRVMNDTVVRSSFLDRHQYIKEKI 240
            :.:          |..|....:..::.:.|.:||.|:||.:::.:.:..:|::|.:....:..:.
Mouse   160 LGW----------QPESQRALLPQLAANAVLFLCGNVVGAYHKALMERALRATFREALSSLHSRR 214

  Fly   241 WLRNARLQEKQLLDSILPPQISLPLQKDIQGRIVMAKQGIHSWTAMERTMAIQIHPDVSILYADV 305
            .|...:..::.||.||||..::..::.:|..|:...::.....|....::.::.|..||:||||:
Mouse   215 RLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQRSRPENTNNFHSLYVKRHQGVSVLYADI 279

  Fly   306 VNYTHLTTTLTVEMLVKVLHDLYGRFDLAAYRYKVQRIKFLGDCYYCVAGLSDPDPDHANNCVIL 370
            |.:|.|.:..:.:.||.:|::|:|:||..|..::..|||.||||||||:||....||||.|||.:
Mouse   280 VGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRM 344

  Fly   371 GLSMINHIMEVRDIHGLDINMRIGVHSGNLFAGVIGEAKLQFDIWGLDVTIANVLESTGVPGCVH 435
            ||.|...|.::|...|:|||||:|||||::..||||..|.|:|:|..|||:||.:|:.||||.||
Mouse   345 GLDMCRAIRKLRVATGVDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVH 409

  Fly   436 ISGATLNNLDVNRFDIEDGPEEARDHPLLKKYRIRSYIIRQDLHMDDEDSDEFLGDLHSISLCNM 500
            |:||||..| ...:.:|....|.|| |.|::....:|::......::::.....|.|.|:....|
Mouse   410 ITGATLALL-AGAYAVERADTEHRD-PYLRELGEPTYLVIDPRAEEEDEKGTAKGLLSSLEGHTM 472

  Fly   501 GAQPRI-------SDSANQSLRALFH-EELREEFRKMPVSAFSPKRLL---------------GI 542
              :|.:       |..|.:....|.| :........:|..||||:..|               |.
Mouse   473 --RPSLLMTRYLESWGAAKPFAHLSHLDSPVSTSTPLPEKAFSPQWSLDRSRTPRGLDDELDTGD 535

  Fly   543 CRF-------NTGKEVPAHQNLN-ICLTFTDPILERAYLKQTDYMYKYSIILSASVGCS-LVYIE 598
            .:|       |:.|:....::.| :.|.|.:..:|:.|.......:||      ...|: ||::.
Mouse   536 AKFFQVIEQLNSQKQWKQSKDFNLLTLYFREKEMEKQYRLSALPAFKY------YAACTFLVFLS 594

  Fly   599 LMDTQMICSS---CFVLPASVATIQCILALIAWYKKY---CWTRYGRNNVPHHYNGFSCFI---- 653
            ....||:.::   ..::..|:..:...|.|...:.::   |..:..:  :.|.....|..:    
Mouse   595 NFTIQMLVTTRPPALIITYSITFLLFFLLLFVCFSEHLTKCVQKGPK--MLHWLPALSVLVATRP 657

  Fly   654 -FRI---HDKILNSLPIRICIYLFLMISSFFVMCLIVMS-----CQREEFEM----AYIEERLFH 705
             ||:   ...||....:.|...|||.:||   .||.:.|     .....:||    ..|...|..
Mouse   658 GFRVALGTATILLVFTMAIASLLFLPVSS---DCLFLASNVSSVTFNASWEMPGSLPLISIPLIS 719

  Fly   706 YEQEAHICFHPWVTTNMLSLMICLTFTFAHIPIMVKTAVAILETLAYLLLIFFQFDFVFHHSVTT 770
            .....|.|        :|..:.|  ..|.|:...:|..:.:|..:|...|      |:..|:..:
Mouse   720 IPYSMHCC--------VLGFLSC--SLFLHMSFELKLLLLLLWLVASCSL------FLHSHAWLS 768

  Fly   771 NPYFKSEYAH----------------ALLICITFLIMFVKERQIEFTNKVNFNWRVDLRKEENAA 819
            :......|..                |:...|.|..:.|..||.|:..:::|.|:..||:|....
Mouse   769 DCLIARLYQSPSDSRPGVLKEPKLMGAIYFFIFFFTLLVLARQNEYYCRLDFLWKKKLRQEREET 833

  Fly   820 SLTNHSIIIILNNILPSHIVDVYLNSLAKHE-LYFENYRMVSVMFAML-----------INFEMD 872
            ....:...::|.|:||:|:...::....::| ||.::|..|.|:||.:           ||.| .
Mouse   834 ETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESNINHE-G 897

  Fly   873 LRSLRVLNEIIAEFDTLLLFYKEYYTVEKIKIVGCTYMAACGLDLNFAGSTSTNRKESIPPTEFN 937
            |..||:||||||:||.||...| :..|||||.:|.|||||.||:......|              
Mouse   898 LECLRLLNEIIADFDELLSKPK-FSGVEKIKTIGSTYMAATGLNATSGQDT-------------- 947

  Fly   938 EEQSRRILFQQSNEDLDEVVFVMTSYALDMMRTLAKSNEAYQSIAGDRNITDGTIAIGISSGEVM 1002
                     ||.:|.....:..|..:|:.:...|...|:        .:..:..:.:|::.|.|:
Mouse   948 ---------QQDSERSCSHLGTMVEFAVALGSKLGVINK--------HSFNNFRLRVGLNHGPVV 995

  Fly  1003 AGIVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTEETSEILQQFGITCSYRGMTFVKGRGKIP 1067
            ||::||.:|.||||||.||:||||||||:.|.|.|||||:..||..|.||..||...|||:|::.
Mouse   996 AGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETARALQSLGYTCYSRGSIKVKGKGELC 1060

  Fly  1068 TYLVGID 1074
            ||.:..|
Mouse  1061 TYFLNTD 1067

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ACXENP_652601.3 AC_N <31..272 CDD:318454 47/225 (21%)
Nucleotidyl_cyc_III 290..459 CDD:325147 82/168 (49%)
Nucleotidyl_cyc_III 851..1071 CDD:325147 89/230 (39%)
Adcy4NP_001348533.1 AC_N <115..246 CDD:318454 33/160 (21%)
Guanylate_cyc 264..418 CDD:306677 79/153 (52%)
DUF1053 479..580 CDD:368844 19/100 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 502..524 6/21 (29%)
Guanylate_cyc 866..1065 CDD:306677 89/231 (39%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D181177at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45627
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
65.880

Return to query results.
Submit another query.