Protein Alignment ACXE and adcy1

DIOPT Version :9

• Sequence 1: NP_652601.3
• Gene: ACXE / 53426
• FlyBaseID: FBgn0040506
• Length: 1123
• Species: Drosophila melanogaster
• Sequence 2: XP_002933461.1
• Gene: adcy1 / 100492373
• XenbaseID: XB-GENE-950909
• Length: 1122
• Species: Xenopus tropicalis
• Alignment Length: 1245
• Identity: 325/1245 - (26%)
• Similarity: 537/1245 - (43%)
• Gaps: 322/1245 - (25%)

  Fly    27 CAELRLESEFRLYRIRLWKSYLLTFFMLHIFVTSVHCALLLATIERRSIIYFDVALSIGCALVLI 91
            |.|  |||.|:.|.::|.::..|....:.|.:|..  ..||..:...|:.....:..:.|.:.|.
 Frog    40 CKE--LESLFQNYNLKLEQTSTLKALAVLIIMTGT--LALLELMSGPSLTISKGSHPVHCIIFLS 100

  Fly    92 LVLSVNFCDEFIAKHTWYMYASSI--FASLTLVFADLTESIYHTYAHSWILGTFYDTYIIYMIYM 154
            |         ||..:..|:..:.:  ...|||:|.                          ..:.
 Frog   101 L---------FIVTNVKYLQVTQLQQIVKLTLLFG--------------------------FTFS 130

  Fly   155 FLPIHFISGAVLLALLVS---GLYILYFVIFIAQGFAQFASALFSVGGMSVDIVH---------- 206
            ||...|..||..|...||   ||:.|..|.|:|.......:.|..|.|..|.:.|
 Frog   131 FLCCPFSLGAYGLEPPVSSEQGLWQLMLVTFVAYALLPVRTLLAIVFGFMVSVSHIIVTATSISP 195

  Fly   207 ---------------YLCLNLVGIFYRVMNDTVVRSSFLDRHQYIKEKIWLRNARLQEKQLLDSI 256
                           ::.:||.|:|.|::.:...|.:||.....|::::.|.:...::::||.|:
 Frog   196 KKKRLWRTLVVNAILFVSVNLSGVFVRILTERAQRKAFLQARNCIEDRLRLEDENEKQERLLMSL 260

  Fly   257 LPPQISLPLQKDIQGRIVMAKQGIHSWTAMERTMAIQIHPDVSILYADVVNYTHLTTTLTVEMLV 321
            ||..:::.:::|.   :...::..|.       :.||.|.:||||:||:|.:|.|.:..|.:.||
 Frog   261 LPRNVAMEMKEDF---LKPPERIFHK-------IYIQRHDNVSILFADIVGFTSLASQCTAQELV 315

  Fly   322 KVLHDLYGRFDLAAYRYKVQRIKFLGDCYYCVAGLSDPDPDHANNCVILGLSMINHIMEVRDIHG 386
            |:|::|:|:||..|.....:|||.||||||||:||:.|..|||:.||.:||.||:.|..|.:...
 Frog   316 KLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATE 380

  Fly   387 LDINMRIGVHSGNLFAGVIGEAKLQFDIWGLDVTIANVLESTGVPGCVHISGATLNNLDVNRFDI 451
            :|:|||:|:|:|.:..||:|..|.|:|:|..|||:|||:|:.|:||.|||:..||..|: ..:::
 Frog   381 VDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAGGLPGKVHITKNTLECLN-GDYEV 444

  Fly   452 EDGPEEARDHPLLKKYRIRS--------------------------------YIIRQDLHMDDED 484
            |.|....| :..|||:.|.:                                |::.|.:|.....
 Frog   445 EPGYGHER-NSFLKKHNIETFFIVPSHRRKIFPGLILSDIKPAKRMKFKTVCYLLVQLMHCRKMF 508

  Fly   485 SDEFLGDLHSISLCNMGAQPRISDSANQSLRALFHEELREEFRKMPVSAFSPKRLLGICRFNT-- 547
            ..|.  ...::..|.       .|...::||.. .|:||..      |:||...:     .||
 Frog   509 KAEI--PFSNVMTCE-------DDDKRRALRTA-SEKLRNR------SSFSTNVI-----HNTPG 552

  Fly   548 -------GKEVPAHQ------NLN-ICLTFTDPILERAYLKQTDYMYKYSIILSASVGC--SLVY 596
                   |:.:.|.|      :|| |.|.:.....|:.|.:..|..:..:::||..:..  .|||
 Frog   553 TRVNRYIGRLIEARQTDSEMSDLNFITLKYKHIEREQKYHQLHDEYFTSAVVLSLILAALFGLVY 617

  Fly   597 IELMDTQ------MICSSCFVLPASVATIQCILALIAWYKKYCWTRYGRNNVPHHYNGFSCFIFR 655
            :.:....      ::...||:       :.||:.|                   |.....||...
 Frog   618 LLIFPQSTIVLILLVFCLCFL-------VACIMYL-------------------HVTRVQCFPGC 656

  Fly   656 IHDKILNSLPIR--ICIYLFLMISSFFVMCLIVMSCQREEFEMAYIEERLFHYEQEAHICFHPWV 718
            :      ::.||  :||::.::|.|....|  |:.|.                         ||:
 Frog   657 L------TIQIRTILCIFIVILIYSVAQGC--VVGCM-------------------------PWI 688

  Fly   719 --TTNMLSLMI--------------CLTFTFAHIPIMVKT-AVAILETLA----YLLLIFFQFDF 762
              :.|..|::|              |.|..:..:..:|.| ::||...::    .:||:|....:
 Frog   689 WRSNNSSSIVIITPKGENKTMNERPCDTAHYTFLSCVVGTLSLAIFLRISSFPKMVLLLFVTILY 753

  Fly   763 V-------FHHSVTTNPYFKSEYAHALLICITFLIMFVKERQIEFTNKVNFNWRVDLRKEEN--- 817
            :       :..::..:..:...|...|.|.:....:.:..||::...::::.|.|...:|.:
 Frog   754 IVILEISGYRKTLGGDTSYMRGYEPILAILLFSCSLALHSRQVDLKLRLDYLWAVQAEEERDDME 818

  Fly   818 AASLTNHSIIIILNNILPSHIVDVYLNSLAKH-ELYFENYRMVSVMFAMLINF----------EM 871
            ...|.|..|:.   |:||:|:...:|.|..:: :||:::|..|.||||.:.||          .|
 Frog   819 RVKLDNKRILF---NLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNM 880

  Fly   872 DLRSLRVLNEIIAEFDTLLLFYKE-YYTVEKIKIVGCTYMAACGLDLNFAGSTSTNRKESIPPTE 935
            .:..||:||||||:||.|:  .|| |..:||||.:|.|||.|.||    ..:|.|..|:||
 Frog   881 GVECLRLLNEIIADFDELM--EKECYKDIEKIKTIGSTYMGAVGL----VPTTGTKAKKSI---- 935

  Fly   936 FNEEQSRRILFQQSNEDLDEVVFVMTSYALDMMRTLAKSNEAYQSIAGDRNITDGTIAIGISSGE 1000
                        .|:      :..:..::::|...|.:.|  |||      ..:..:.:||:.|.
 Frog   936 ------------YSH------LSTLADFSIEMFDVLDEIN--YQS------YNEFVLRVGINVGP 974

  Fly  1001 VMAGIVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTEETSEILQQFGITCSY----RGMTFVK 1061
            |:||::||.:|.||||||.||:||||:|||:.|.|.|||:...||:    :|:|    ||...||
 Frog   975 VVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGKIQVTEDVHRILK----SCNYEFVCRGKVSVK 1035

  Fly  1062 GRGKIPTYLV--GID------ENLN----FIPQKATRFPSHQERS-TVISLQSTYTHAENNNSIA 1113
            |:|::.||.:  .||      .:||    ..|...|...:....| ..:|..|.:.......::.
 Frog  1036 GKGEMLTYFLEGKIDGTNSQTRSLNLERKMYPYGRTNIQTKLGTSCPAVSSISNFPVKAGQGALQ 1100

  Fly  1114 STSRHTLQSL 1123
            .|:.|..|:|
 Frog  1101 PTTSHANQTL 1110

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	57/270 (21%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	79/168 (47%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147	89/234 (38%)
adcy1	XP_002933461.1	AC_N	<37..282	CDD:292831	59/283 (21%)
		CYCc	248..443	CDD:214485	84/205 (41%)
		Guanylate_cyc	284..466	CDD:278633	84/183 (46%)
		CYCc	817..1028	CDD:214485	90/253 (36%)
		Guanylate_cyc	850..1047	CDD:278633	89/236 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910