DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXE and gucy1b1

DIOPT Version :9

Sequence 1:	NP_652601.3	Gene:	ACXE / 53426	FlyBaseID:	FBgn0040506	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	XP_004911214.1	Gene:	gucy1b1 / 100379900	XenbaseID:	XB-GENE-950986	Length:	618	Species:	Xenopus tropicalis

Alignment Length:	275	Identity:	72/275 - (26%)
Similarity:	132/275 - (48%)	Gaps:	60/275 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   203 DIVHYLC----LNLVGIFYR--VMNDTVVRSSFLD--------RHQY-IKEKIWLRNARLQ---- 248
            |.:.:||    :||..:..|  .::|..:..:..|        |.:| :.:::.:...|||
Frog   317 DNILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQHTLR 381

  Fly   249 ----EKQ----LLDSILPPQISLPLQKDIQGRIVMAKQGIHSWTAMERTMAIQIHPDVSILYADV 305
                ||:    ||.|:|||.::..|:   ..|.|.||:                :.:|:||::.:
Frog   382 ALEDEKKKTDTLLYSVLPPSVANELR---HKRPVPAKR----------------YDNVTILFSGI 427

  Fly   306 VNY-THLTTTLTVE---MLVKVLHDLYGRFDLAA------YRYKVQRIKFLGDCYYCVAGLSDPD 360
            |.: |..:...:.|   .:|.:|:|:|.|||:..      |.|||:.:   ||.|..|:|:.:|.
Frog   428 VGFNTFCSKHASGEGAMKIVNLLNDIYTRFDILTDSRNNPYVYKVETV---GDKYMTVSGIPEPC 489

  Fly   361 PDHANNCVILGLSMINHIMEVRDIHGLDINMRIGVHSGNLFAGVIGEAKLQFDIWGLDVTIANVL 425
            ..||.:...|.|.|:....:|: :.|..:.:.||:|:|.:..||||:...::.::|..|.:.:..
Frog   490 VHHARSICHLALDMMEIAGQVQ-VDGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRT 553

  Fly   426 ESTGVPGCVHISGAT 440
            |:||..|.:::|..|
Frog   554 ETTGEKGKINVSEYT 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	22/95 (23%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	46/161 (29%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147
gucy1b1	XP_004911214.1	HNOB	2..166	CDD:377902
		HNOBA	207..406	CDD:369471	21/88 (24%)
		Guanylate_cyc	412..605	CDD:306677	49/177 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910