Protein Alignment ACXE and adcy9

DIOPT Version :10

• Sequence 1: NP_652601.3
• Gene: ACXE / 53426
• FlyBaseID: FBgn0040506
• Length: 1123
• Species: Drosophila melanogaster
• Sequence 2: XP_003201145.3
• Gene: adcy9 / 100333702
• ZFINID: ZDB-GENE-050208-455
• Length: 1392
• Species: Danio rerio
• Alignment Length: 1382
• Identity: 322/1382 - (23%)
• Similarity: 527/1382 - (38%)
• Gaps: 415/1382 - (30%)

  Fly     3 RSLGNCQLNYSKERMWEPGY----LKAKCAELRLESEFRLYRIRLWKSYLLTFFML---HIFVTS 60
            ||...|         |:|.:    |:..|.|.......|.:|..|:  ||.|..:|   :..:.|
Zfish    88 RSAAQC---------WDPKFDSSILEEACRERCFPQMQRRFRYILF--YLATAALLWGIYFGINS 141

  Fly    61 VHCALLLATIERRSIIYFDVALSIGCALVLILVLSVNFCDEFIAKHTWYMYASSIFASLTLVFAD 125
            ..|       |..:.:.......|.|.::|....:..:...:  .||.::....:| .:||....
Zfish   142 SRC-------EPTNFLVPTAGFLILCLVLLWFTFTKPYSRYY--NHTSFLLTVIMF-GITLAPQT 196

  Fly   126 LTESIYHTYAH--------------SWI--LGTF---YDTYIIYMIYMFLPIHFISGAVLLALLV 171
            .|....|..:|              |.|  :|||   .:..::....:.||::   .:|||.||.
Zfish   197 QTAHFAHYDSHRADNQSPLPVYQNASCISPVGTFSLCMEVLLLLYSVLHLPLY---ASVLLGLLY 258

  Fly   172 SGLYILYFVIFIAQ------GFAQFASALFSVGGMSVDIVHYLCLNLVGIFYRVMNDTVVRSSFL 230
            |.||.....:.:||      |..:..|...|..|....::| ||.::|||...:|::...||:||
Zfish   259 SVLYEALGWLHLAQLDESYVGSREGISGTLSWLGPGKFLLH-LCAHVVGIHIFIMSEVRSRSTFL 322

  Fly   231 DRHQYIKEKIWLRNARLQEKQLLDSILPPQISLPLQK------DIQGRIVMA------------- 276
            ...|.|.....|...:..:::::.|::|..::..|.|      :..|:...|
Zfish   323 KVGQAIMHGKDLEVEKALKERMIHSVMPRSVADELMKQGDEESESSGKRYSAGTCSVAAAAAVTS 387

  Fly   277 ---------KQGIHSWTAMERTMAIQIHPDVSILYADVVNYTHLTTTLTVEMLVKVLHDLYGRFD 332
                     |..|.....:.|...::....||||:||:|.:|.::...:...||.:|:||:||||
Zfish   388 SSPKSHKRKKNSIPRGQIIFRPFNMKRMEPVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFD 452

  Fly   333 LAAYRYKVQRIKFLGDCYYCVAGLSDPDPDHANNCVILGLSMINHIMEVRDIHGLDINMRIGVHS 397
            ........::|..||||||||||..:|..|||..||.:||.||..|.:........:|||:|||:
Zfish   453 RLCELTSCEKISTLGDCYYCVAGCPEPLTDHAYCCVEMGLGMIQAIEQFCQEMSETVNMRVGVHT 517

  Fly   398 GNLFAGVIGEAKLQFDIWGLDVTIANVLESTGVPGCVHISGATLNNLDVNRFDIEDGPE-EARDH 461
            |.:..|::|..:.:||:|..||.:||::|..||.|.||:|..|...|| :|::.|||.. |...|
Zfish   518 GTVLCGILGMKRFKFDVWSNDVNLANLMEQLGVAGKVHLSEVTAGFLD-DRYEREDGRVIERVGH 581

  Fly   462 PLLKKYR-IRSYIIRQDLHMDDEDSDEFLGDLHSISLCNMG-----------------------A 502
            .:..:.: :::|:|          |...||.....|..::|                       |
Zfish   582 SVTDQLKGLKTYLI----------SGRKLGSQCGCSQLSLGQEFGETLSPSSNTHTPDHTHCAIA 636

  Fly   503 QPR--------------------ISDSANQSLRALFHEELREEFRKMPVSAFSPKRLLG----IC 543
            :|:                    .:|.|.|:   ...:|.|....|.|... |||.|.|    :|
Zfish   637 EPQSHGKAGFMPCSISIDVVDNPTTDEATQN---GCQDEHRANSSKFPAGR-SPKALNGLLSPLC 697

  Fly   544 RFNTG-----------------------------------------------KEVPAHQNL---- 557
            ....|                                               .||....:|
Zfish   698 EERVGVSQSSLCDKLQEKDRSWAGSLAAEGKDHSAILPLRSKNFREKSDAHFVEVIKEDSLMKDY 762

  Fly   558 -------NICLTFTDPILERAYLKQTDYMYKYSIILSASVGCSLVYIELMDTQMICS-------S 608
                   .:.|.|.:..||.||  :|.|..:....:......|.|:..|:|..:.|:       :
Zfish   763 FFKPPINKLSLNFLEKSLESAY--RTSYHEQVMNHVPVQTFASPVFSSLLDVLLSCTVFLALTMA 825

  Fly   609 CFVLP---------------ASVATIQCILALIAWYKKYC-----------------WTRYGRNN 641
            ||:.|               .:.|.::.:..|::....:|                 |
Zfish   826 CFLYPLVSMQTPLAATLGLAITAALLELVSLLLSIRMIFCLDDVQNCSRILLKLVSGW------- 883

  Fly   642 VPHHYNGFSCFIFRIHDKILNSLPIRICIYLFLMIS-------SFFVMCLIVMSCQREEFEMAYI 699
            ||.|..|          .:|.||| .:.::..|..|       :.|:.|.::::.
Zfish   884 VPRHVIG----------AVLVSLP-AVSVFSHLAYSLQLPIQVTMFLCCALIIAI---------- 927

  Fly   700 EERLFHYEQEAHICFHPWVTTNMLSLMICLTFTFAHIPIMVKTAVAILETLAYLLLI-------- 756
                                     :..|   ||..:...:::|:|.:..|:.|:|:
Zfish   928 -------------------------IQYC---TFCQLSFWMRSALATVVGLSLLILLYSASIRTS 964

  Fly   757 ----FFQFDFVFHHSVTTNPYFKSEYAHA---LLICITFLIMFV-------KERQIEFTNKVNFN 807
                |..|..:.:.|...:...:|..|..   ||:..|.|..|:       ..|:.|.:.:::::
Zfish   965 ATDAFPGFGNMSNQSAQVDLLGESNSAPTALDLLVLETVLSFFLLLLLVWFLNREFEVSYRLHYH 1029

  Fly   808 WRVDLRKEENAASLTNHSIIIILNNILPSHIVDVYLNSLAKHELYFENYRMVSVMFAMLINF--- 869
            ..|:..|..............:|.||:|.|:.:    .|..::.|.:|:..|.|:||.::||
Zfish  1030 GNVEADKHRIKIQTMRDQADWLLRNIIPIHVAE----QLKVNQSYSKNHDNVGVIFASIVNFSEF 1090

  Fly   870 -----EMDLRSLRVLNEIIAEFDTLLLFYKEYYTVEKIKIVGCTYMAACGLDLNFAGSTSTNRKE 929
                 |......|||||:|.:||.||. ...:..|||||.:|.|||||.||
Zfish  1091 YEESYEGGKECYRVLNELIGDFDELLR-QPAFSNVEKIKTIGATYMAASGL-------------- 1140

  Fly   930 SIPPTEFNEEQSRRILFQQSNEDLDEVVFVMTSYALDMMRTLAKSNEAYQSIAGDRNITDGTIAI 994
                   |.:|.      |........:..:..:||:|||.:...|   :::.|.:    ..:.|
Zfish  1141 -------NGQQC------QEQPHPHAHLCALFDFALEMMRVVDDFN---KNMLGFK----FKLRI 1185

  Fly   995 GISSGEVMAGIVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTEETSEILQQFGITCSYRGMTF 1059
            |.:.|.:.||::|.::..|||||:.||:||||:|||:...|.|:||:..:|.:......|||...
Zfish  1186 GFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDSTGVECRIQVSEESHCVLSRMNYAFDYRGTVN 1250

  Fly  1060 VKGRGKIPTYL--------VGIDENLNFIPQKATRFPSHQERSTVISLQ-------STYTHA--- 1106
            |||:|::.|||        :|..::|              |:..|.||:       :|.|||
Zfish  1251 VKGKGQMRTYLFPQMNEGGMGSTQSL--------------EQGQVDSLEPSTLANTTTPTHAAPL 1301

  Fly  1107 ---ENNNSIASTSRHTL 1120
               .|:.:.||.|.|::
Zfish  1302 IPPSNSPNAASISGHSV 1318

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AcyC	65..453	CDD:441717	122/440 (28%)
		Nucleotidyl_cyc_III	290..459	CDD:448371	70/169 (41%)
		Nucleotidyl_cyc_III	851..1071	CDD:448371	77/235 (33%)
adcy9	XP_003201145.3	None