Protein Alignment ACXE and gucy2g

DIOPT Version :9

• Sequence 1: NP_652601.3
• Gene: ACXE / 53426
• FlyBaseID: FBgn0040506
• Length: 1123
• Species: Drosophila melanogaster
• Sequence 2: XP_009305067.2
• Gene: gucy2g / 100333350
• ZFINID: ZDB-GENE-130531-70
• Length: 1127
• Species: Danio rerio
• Alignment Length: 1320
• Identity: 243/1320 - (18%)
• Similarity: 431/1320 - (32%)
• Gaps: 463/1320 - (35%)

  Fly    41 IRLWKSYLLTFFMLHIFVTSVHC------ALLLATIERRSIIYFDVALSIGCALVLIL------- 92
            ||.|       .:...|..||.|      .|.:.....|:|.|....|.:|.|:.:.:
Zfish    13 IRWW-------LLFTAFTNSVICNKDGQFKLTVGLQAPRNISYPFSLLRLGSAMQIAMDKINSNP 70

  Fly    93 VLSVNFCDEFIAKHT---------------WYMYASSIFASLTLVFADLTESIYHTYAHSWILGT 142
            .||.||..:|:...|               .....|::|.......|::|..|    |.:|.:..
Zfish    71 ALSGNFTFDFVYMDTDCNAKTSLRGFIEQVMEQNVSALFGPPCPEEAEVTGLI----ASTWNIPM 131

  Fly   143 F--------------YDTYIIYMIYMFLPIHFISGAVLLALLVSGLYILYFVIFIAQGFAQFASA 193
            |              ||||    |.:..|:..:...:|.||...|...:..:     |....|:.
Zfish   132 FGFVGQTPKMDNIQVYDTY----IKIVPPLKRVGEILLKALEFFGWKHVGMI-----GGGADANT 187

  Fly   194 LFSVGGM--SVDIVHYLCLNLVGIFYRVMNDTVVRSSFLDRHQYIKEKIW-----------LRNA 245
            ..||..:  |||                              |.::.|:.           |..|
Zfish   188 WDSVEALWKSVD------------------------------QQLRSKVTVTMGIKFDTSDLEQA 222

  Fly   246 RLQEKQLLDSILPPQISLPLQKDIQGRIVMAKQ-----GIHSWTAMERTMAIQIHPDVSILYADV 305
            : :..|::..:....:.|...:|....::.|::     |.:.:..:::   .::...|..|:...
Zfish   223 K-RNLQIISKVARVVVVLANAEDSTAMMIEAQKLGLMSGEYVFLLVQQ---FEVSGKVDNLWKTS 283

  Fly   306 VNYTHLTTTLTVEM---LVKVLHDLYGRFDLAAYRYKVQRIKFLGDCYYCVAGLSDPD-----PD 362
            |:.|:.|.....:|   |.:..:|.|..:|.....|.    |..||.:|  :.||...     ..
Zfish   284 VSETNRTMLKAFDMVFVLAEKSYDGYDYYDFFDQAYD----KLKGDPFY--SNLSSVKEVSSYAA 342

  Fly   363 HANNCVIL-GLSMINHIMEVRDI-HGLDINMRIGVHSGNLFAGV--------IGEAKLQFDIWGL 417
            :.::.|:| .:.:.......:|| ||.:|..::...:...|.|.        .||..|.:.::.|
Zfish   343 YLHDAVLLYAMGLKEAFKSGKDIRHGREIVQKLRDRTSIRFYGASGLVHFDEYGERNLDYSVYDL 407

  Fly   418 DVT------------------------IANVLESTGVPGCVHISGATLNNLDVNRFDIEDGPEEA 458
            ..|                        .:|::...|.|.                   .|.|...
Zfish   408 QQTETLIQFVSVLDFDSHTKMIKPTLRFSNIVWQNGKPP-------------------TDNPSCG 453

  Fly   459 RDHPL--------------------------------LKKYRIRSYIIRQDLHMDDEDSDEFLGD 491
            .|:.|                                |:|.|::|.:         ::|:.:|.:
Zfish   454 FDNELCEWLDNEISLLVLLVALPLIGVAAVSLITLLTLQKLRLQSRL---------DESNWWLIN 509

  Fly   492 LHSISL------------------CNM-GAQPRISDSANQSLRALF-------HEELREEFRKMP 530
            ...|::                  |.. |:|..:|.::..:..|::       ..|:..::.|..
Zfish   510 YSDITILREPKGTQILSVNTTPSKCGSGGSQSMLSSNSCNTREAIYATVGLFQGNEVGIKYLKNQ 574

  Fly   531 VSAFSPKRLLGICRFNTGKEVPAHQNL-----------NICLTFTDPILERAYLKQT-------- 576
            :.....|..: |..||..||: .|:||           |:|:..  ...::..||..
Zfish   575 IIPDIKKPSI-IAEFNMLKEM-KHENLVQFFGVCIDPPNVCIVM--QYCKKGSLKDVLGNHEIDL 635

  Fly   577 DYMYKYSIILSASVGCSLVYIELMDT--QMICSSCFVLPASVATIQCILALIAWYKKYCWTRYGR 639
            |:|:|.|.......|...::...:.:  .:..|:|.|    .:.:|..|:....::..|.|::
Zfish   636 DWMFKLSFAYDIVNGMEYIHKSSLKSHGNLRPSTCLV----DSRLQIKLSGFGLWEFKCGTKH-- 694

  Fly   640 NNVPHHYNGFSCFIFRIHDKILNSLPIRICIYLFLMISSFFVMCLIVMSCQREEFEMAYIEERLF 704
                                  ..:|:                       ...::|..|.....|
Zfish   695 ----------------------RLIPL-----------------------DSPKYEEMYWTAPEF 714

  Fly   705 HYEQEAHICFHPWVTTNMLSLMICLTFTFAHIPIMVKTAVAILETLAYLLLIFFQFDFVFHHSVT 769
            ..|     .|:|:..|....:     ::||   |:::..:...|...|             |.|.
Zfish   715 LRE-----IFYPFNGTQKGDV-----YSFA---IIIRELIYSTEVGPY-------------HDVH 753

  Fly   770 TNPY---------FKSEYAHALL---ICITFLIMFVK----------------ERQIE------- 799
            ..|.         ...|.....|   ||...||..:|                .||:.
Zfish   754 LEPKEIIKQLRTPMSEEPLRPTLSADICDERLIPLIKACWSENPDHRPPFGSIRRQLRDACPESH 818

  Fly   800 ---FTNKVNFNWRVDLRK---------EENAASLT--NHSIIIILNNILPSHIVDVYLNSLAKHE 850
               ..|.||     .|.|         ||..:.||  ......:|:::||.:|.|   ..:|...
Zfish   819 ANILDNMVN-----KLEKYANHLEEVVEERTSQLTVEKSRADKLLSSMLPRYIAD---QLMAGKS 875

  Fly   851 LYFENYRMVSVMFAMLINF------EMDLRSLRVLNEIIAEFDTLLLFYKEYYTVEKIKIVGCTY 909
            :...:|.||::.|:.::.|      ...|..:.:||::.:.||.::..|..|    |::.:|..|
Zfish   876 VEPRSYEMVTIFFSDIVGFTTMCSVSSALEVVTLLNDLYSLFDDIIKLYDVY----KVETIGDAY 936

  Fly   910 MAACGLDLNFAGSTSTNRKESIPPTEFNEEQSRRILFQQSNEDLDEVVFVMTSYALDMMRTLAKS 974
            |.|.||.:    |..|...|.|                             ::.||..:.::.:.
Zfish   937 MVASGLPI----SNGTLHAEEI-----------------------------STMALHFLSSIKRF 968

  Fly   975 NEAYQSIAGDRNITDGTIA--IGISSGEVMAGIVGASQPHYDIWGNPVNMASRMESTGLPGHIHV 1037
            .        .|::.:..:|  |||:||.|:||:||::.|.|.::|:.||.||||||..||..||:
Zfish   969 K--------IRHLPNERLALRIGINSGPVVAGVVGSTMPRYCLFGDTVNTASRMESNSLPLKIHI 1025

  Fly  1038 TEETSEILQQFG-ITCSYRGMTFVKGRGKIPTYLVGIDENLNFIPQKATRFPSHQERSTVISLQS 1101
            ::.|::||...| .....||...:||:|...|:.:.......|.|......||.:..:....::.
Zfish  1026 SQSTADILLTIGTFELEERGDIEIKGKGTQKTFWLLSKPGFTFPPTGQDSNPSPKSGTDSCHIKQ 1090

  Fly  1102 TYTHAENNNSIASTSRHTLQ 1121
            ..|.|.|:...  ..|.|:|
Zfish  1091 EKTKAANDGDF--KERRTIQ 1108

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	52/285 (18%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	36/210 (17%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147	62/228 (27%)
gucy2g	XP_009305067.2	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810