Protein Alignment ACXE and adcy8

DIOPT Version :9

• Sequence 1: NP_652601.3
• Gene: ACXE / 53426
• FlyBaseID: FBgn0040506
• Length: 1123
• Species: Drosophila melanogaster
• Sequence 2: NP_001137224.1
• Gene: adcy8 / 100148976
• ZFINID: ZDB-GENE-070912-197
• Length: 1225
• Species: Danio rerio
• Alignment Length: 1232
• Identity: 343/1232 - (27%)
• Similarity: 559/1232 - (45%)
• Gaps: 281/1232 - (22%)

  Fly    21 GYLKAKCAELRLESEFRL-----YR----------------IRLWKSYL---------------- 48
            |:|:..||.  ..|:|.|     ||                .||::.|.
Zfish   102 GFLQIDCAP--SNSDFFLSWGYTYRGVIFPTLRYAFKSRDLERLYQRYFLGQRRKSVVVMNILDV 164

  Fly    49 ---LTFFMLHIFVTSVHCALLLATIERRSIIYFDVALSIGCALVLILV-LSVNFCDEFIAKHTWY 109
               ||..:||:.:.|..    :..|:...:.:|.....:.||||::.. .|.:...::....||.
Zfish   165 VTKLTLLVLHLTLASTP----MDPIKGMLLGFFTGIEVVICALVVVRKDTSSHGYLQYSGAVTWV 225

  Fly   110 MYASSIFASLTLVFADLTESIYHTYAHSWILGTFYDTYIIYMIYMFLPIHFISGAVLLALLVSGL 174
            ..|:.|.|: .|.:..|.:.|      .::|.|.:.|      |..||:. ::.|::..||.|.|
Zfish   226 AMATQILAT-GLGYGLLGDGI------GYVLFTLFAT------YSMLPLP-LTWAIVAGLLTSAL 276

  Fly   175 YILYFVIFIAQGFAQFASALFSVGGMSVDIVHYLCLNLVGIFYRVMNDTVVRSSFLDRHQYIKEK 239
            :|...::...:       |..|...:...::.:||:|..|:|...::|...|.:||:..:.|:.:
Zfish   277 HIALQLLVPPR-------AQISTNQLLAQVLLFLCINTAGMFISYLSDRAQRQAFLETRRCIEAR 334

  Fly   240 IWLRNARLQEKQLLDSILPPQISLPLQKDIQGRIVMAKQGIHSWTAMERTMAIQIH--PDVSILY 302
            :.|.....::::|:.|:||..:.|.:..|:        ..:...|...:...|.||  .:||||:
Zfish   335 LRLETENQRQERLVLSVLPRFVVLEMINDM--------TNVEDETLQHQFHRIYIHRYENVSILF 391

  Fly   303 ADVVNYTHLTTTLTVEMLVKVLHDLYGRFDLAAYRYKVQRIKFLGDCYYCVAGLSDPDPDHANNC 367
            |||..:|:|:|||:.:.||::|::|:.|||..|:.:...|||.||||||||:||.:|.||||:.|
Zfish   392 ADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRPDHAHCC 456

  Fly   368 VILGLSMINHIMEVRDIHGLDINMRIGVHSGNLFAGVIGEAKLQFDIWGLDVTIANVLESTGVPG 432
            |.:|||||..|..||.....||:||||:|||::..||:|..|.|||:|..||.|||.|||.|:||
Zfish   457 VEMGLSMIKTIRYVRSRTKHDIDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPG 521

  Fly   433 CVHISGATLNNLDVNRFDIEDGPEEARDHPLLKKYRIRSYIIRQ----------DLHMDDEDSDE 487
            .:|||.|.|:.|: ..:::|:|..:.| :..|:::.|.:::|:|          |:..|..:..:
Zfish   522 RIHISKAALDCLN-GDYEVEEGHGKDR-NDFLRRHNIETFLIKQPEESLLTLPEDIMRDSTNQSD 584

  Fly   488 F---------------------------LGDL--HSISLC-NMGAQPRISDSANQSLRALFHEEL 522
            .                           |..|  |||:|. |..||.....:.:|.:.|.....:
Zfish   585 HRTSNTSFTEGTWSPELPFHNIVGKQNTLAALTRHSINLLPNHLAQALHVRAGSQEINARMQSTI 649

  Fly   523 R----EEFRKMPVSAFSPKRLLGICRFNTGKEVPAHQNLNICLTFTDPILERAYLKQTDYMYKYS 583
            .    ::.|:..:|.||                         |||.:.:||..|.:..|.::|.:
Zfish   650 ALRSGDKLRQEHISPFS-------------------------LTFREALLEHKYSQMRDEVFKSN 689

  Fly   584 -----IILSASVGC-SLVYIELMDTQMICSSCFVLPASVATIQCILALIAWYKKY---------- 632
                 |:|....|. ||:....|.|.:|..|..:|      :.|.|.::...:.|
Zfish   690 LVCAFIVLFFITGIQSLLPSARMVTMLIQFSVLIL------LHCCLVVVTTAEDYKCLPLVLRKA 748

  Fly   633 -CWTR--YGRNNVPHHYNGFSCFIFRIHDKILNSLPIRICIYLFLMISSFFVMCLIVMSCQREEF 694
             ||..  |...||                          .|:|.::| :|....:.::.|   :|
Zfish   749 CCWVNETYAARNV--------------------------VIFLSILI-NFLAAMINILWC---DF 783

  Fly   695 EMA-YIEERLFHYEQE-AHICFHP--WVTTNMLSLMICLTFTFAHIPIMVKTAVAILETLAYLLL 755
            :.: ....:.|:.... ..|||:|  :|.|.:|:::.|.  .|..:..::|.|:.::....|.:|
Zfish   784 DKSGSFRNQTFNASASIPDICFYPEYFVFTGVLAMVTCA--VFLRLNSVLKLAILLIMIAIYAVL 846

  Fly   756 --IFFQFDFVFHHSVTTN---PYFKSEYAHALLICITFLIMFVKERQIEFTNKVNFNWRVDLRKE 815
              .|:...|:.:.::|.|   .:..::....||:.:..|.:|...:|:|:|.:::|.|||..::|
Zfish   847 TEAFYTPLFIRYDTLTLNQSKSFLGTKETSLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEE 911

  Fly   816 EN-AASLTNHSIIIILNNILPSHIVDVYL-NSLAKHELYFENYRMVSVMFAMLINF-------EM 871
            .| ...|..|: ..:|.||||||:...:| ......|||.::|..|.||||.:..|       ||
Zfish   912 INEMRELREHN-ENMLRNILPSHVARHFLEKDRDNEELYSQSYDTVGVMFASIPGFADFYSQTEM 975

  Fly   872 D---LRSLRVLNEIIAEFDTLLLFYKEYYTVEKIKIVGCTYMAACGLDLNFAGSTSTNRKESIPP 933
            :   :..||:||||||:||. ||..:.:..:||||.:|.||||..||...
Zfish   976 NNQGVECLRLLNEIIADFDE-LLGEERFQDIEKIKTIGSTYMAVSGLSPE--------------- 1024

  Fly   934 TEFNEEQSRRILFQQSNEDLDEVVFVMTSYALDMMRTLAKSNEAYQSIAGDRNITDGTIAIGISS 998
                         :|..||....:..:..:|:.:       ||:.|.| ...:..:..:.||::.
Zfish  1025 -------------KQQCEDKWGHLCALADFAIAL-------NESIQEI-NKHSFNNFQLRIGMAH 1068

  Fly   999 GEVMAGIVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTEETSEILQQFGITCSYRGMTFVKG- 1062
            |.|:||::||.:|.|||||..||:||||:|||:.|.|.:.|||..||.:.|....|||..:|||
Zfish  1069 GSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGKIQLPEETYAILNERGFAFEYRGEIYVKGI 1133

  Fly  1063 ---RGKIPT-YLVG-IDEN-LNFIPQKATRFPSHQERSTVISLQSTYTHA-------ENNNS 1111
               .|||.| :::| :..| |...|:|.|  ..:...:.|:.|..:....       |||||
Zfish  1134 SEQEGKIRTHFMIGRVQPNPLILQPRKLT--GQYSLAAVVLGLVQSLNRQKQKQILNENNNS 1193

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	59/281 (21%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	87/170 (51%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147	83/234 (35%)
adcy8	NP_001137224.1	AC_N	<135..374	CDD:292831	55/271 (20%)
		CYCc	340..538	CDD:214485	92/206 (45%)
		Guanylate_cyc	379..563	CDD:278633	91/185 (49%)
		DUF1053	592..685	CDD:283888	22/117 (19%)
		CYCc	919..1123	CDD:214485	83/241 (34%)
		Guanylate_cyc	948..1147	CDD:278633	83/235 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910