DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alk and SCH9

DIOPT Version :9

Sequence 1:	NP_001261027.1	Gene:	Alk / 53425	FlyBaseID:	FBgn0040505	Length:	1701	Species:	Drosophila melanogaster
Sequence 2:	NP_012075.1	Gene:	SCH9 / 856612	SGDID:	S000001248	Length:	824	Species:	Saccharomyces cerevisiae

Alignment Length:	471	Identity:	103/471 - (21%)
Similarity:	173/471 - (36%)	Gaps:	128/471 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  1135 KQSKKRHKMLVEQDLQLTRLRNNIDDSNLNNFNPNYGCDGILNGHIDVNSLPQVARDSLQLVNAL 1199
            ||:||||                            ||              ||    ..:::..|
Yeast   400 KQTKKRH----------------------------YG--------------PQ----DFEVLRLL 418

  Fly  1200 GKGAFGEVYMALYRHRDGDAVEMGVAVKTLREDPKREKEE--DFLKEAAIMAKFNHPNMVHLIGV 1262
            |||.||:||..  :.:|...:   .|:|.|.:....:|.|  ..:.|..|:......:...::|:
Yeast   419 GKGTFGQVYQV--KKKDTQRI---YAMKVLSKKVIVKKNEIAHTIGERNILVTTASKSSPFIVGL 478

  Fly  1263 CFDRQ---PYYIVLELLAGGDLQKFL-RENRNTPERPSLLTMKDLLFCALDVAKGCRYMESKRFI 1323
            .|..|   ..|:|.:.::||:|...| :|.|.:.:|..        |...::.....::.....:
Yeast   479 KFSFQTPTDLYLVTDYMSGGELFWHLQKEGRFSEDRAK--------FYIAELVLALEHLHDNDIV 535

  Fly  1324 HRDIAARNCLLSSKGPGRVVKIADFGMSRDIYRSDYYRKGGKAMLPIKWMPPEAFLDGI-FTSKT 1387
            :||:...|.||.:.|.   :.:.|||:|    ::|...:........:::.||..||.. :|...
Yeast   536 YRDLKPENILLDANGN---IALCDFGLS----KADLKDRTNTFCGTTEYLAPELLLDETGYTKMV 593

  Fly  1388 DVWSFGILLWEVFSLGRSPYPGQHNTQVMELVVRGGRLGSPTECPVSIYKVMADCWNPTPEDRPT 1452
            |.||.|:|::|: ..|.||:..::| |.|...:..|::..|.:       |::.      |.|..
Yeast   594 DFWSLGVLIFEM-CCGWSPFFAENN-QKMYQKIAFGKVKFPRD-------VLSQ------EGRSF 643

  Fly  1453 FITLL----EHLTACTQDASIMNA---------------PLPNILGP-TASERDDTVIRPPNGEE 1497
            ...||    :|......|...:.|               .:|....| ..||.|.:...|    |
Yeast   644 VKGLLNRNPKHRLGAIDDGRELRAHPFFADIDWEALKQKKIPPPFKPHLVSETDTSNFDP----E 704

  Fly  1498 FCLAVPDYL---VPLPPGGSNNPSMA---SGSGYVPEL--------QRQ--QMSSCTPPAVTSPA 1546
            |..|...|:   .|:......:|:|.   :|..:|.|.        .|:  |.|....|....|.
Yeast   705 FTTASTSYMNKHQPMMTATPLSPAMQAKFAGFTFVDESAIDEHVNNNRKFLQNSYFMEPGSFIPG 769

  Fly  1547 APHPRPVENIAPTSGD 1562
            .|:..|.|::....||
Yeast   770 NPNLPPDEDVIDDDGD 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alk	NP_001261027.1	MAM	288..450	CDD:279023
		MAM	288..447	CDD:99706
		MAM	505..691	CDD:279023
		MAM	505..689	CDD:99706
		PTKc_ALK_LTK	1186..1462	CDD:270632	67/286 (23%)
		TyrKc	1193..1460	CDD:197581	64/277 (23%)
SCH9	NP_012075.1	YPK1_N_like	181..407	CDD:212165	6/34 (18%)
SCH9	NP_012075.1	STKc_Sck1_like	418..738	CDD:270738	81/358 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000