DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alk and AT5G57610

DIOPT Version :9

Sequence 1:	NP_001261027.1	Gene:	Alk / 53425	FlyBaseID:	FBgn0040505	Length:	1701	Species:	Drosophila melanogaster
Sequence 2:	NP_200569.1	Gene:	AT5G57610 / 835865	AraportID:	AT5G57610	Length:	1054	Species:	Arabidopsis thaliana

Alignment Length:	1000	Identity:	216/1000 - (21%)
Similarity:	356/1000 - (35%)	Gaps:	288/1000 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   582 VSKTFNP--PPSVHGNPDSPYRNSCVVRFFIHQFGKNPGS--INLSVVEMKEKENITTTLWWSTK 642
            |..|::|  .|..||:.|.        |.| .:|..:|.|  ..:...|:.:|
plant   231 VEGTWSPFYSPRHHGHHDP--------RTF-QEFPSSPSSARYRMPYGEIPDK------------ 274

  Fly   643 NQGSDWMRAEYVLPNITSKYYLQFEARMGMRIYSDVAVDDFSLSPEC---FGLNIPEDHLGGYNY 704
              |.|.|..|||.|..:...:.:.:|.:...:   |.|...::.||.   |..|:.....|||..
plant   275 --GLDRMPEEYVRPQASHHPFYEHQAHIPDSV---VWVPAGAMPPESKGGFPGNVLHGGPGGYEG 334

  Fly   705 WDVRQNLKSPTYKDFEYTNYLELTTCDTRGMIGPSQAQC-----------------EAAYREQNK 752
            .:..:|.:.|.:::.:   .||.:.....|......|.|                 ..||  .|:
plant   335 GNGCENCRVPYHRNHQ---LLEQSNIGNNGFPPVHCAHCPPNRESFLLNTDPKPTHHGAY--PNE 394

  Fly   753 TH-------VLREVH-----VVEDQSSYKGMQKWKVPHEGHYTIIAKGASGGLGS---------- 795
            |.       |.::|:     :.|.:|....:.:   |:: |||.....::..||.
plant   395 TFGPDRGWMVQQQVNPNPPRIEEGRSHISNVGR---PND-HYTPDYPVSNYPLGQRAGHEISNEG 455

  Fly   796 ------GGVGSSRGSVAVAILELHKNEELYFLVGQQGENACIKSMGVLKEAGCGTDH-------- 846
                  ||:..:..:.:......|....||    ..|.::       :..||....|
plant   456 FHDKPLGGIPLNSANRSAEERGFHYGNNLY----PPGPDS-------IHSAGHSHMHHPQPNIWQ 509

  Fly   847 ----------DLDLAQYSFRSKQDMVKNIYIENGAGGGGGGSYVFLLNQAKNEAVPLLVAGGGGG 901
                      .|.: |.:....|.:::| .||.......|     :.||......|..::|..|.
plant   510 NVSNPIAGPPGLPM-QINGTVNQTVIRN-PIETAPRYSTG-----MENQGVLVGSPQRISGFDGM 567

  Fly   902 LGIGQ--YIDEDFQHGQKAKPLQ----APESGQINGEPLNKKTAGPGGGWRAKEDQALSPTYGAA 960
            ..:||  |.:...|  .:|.||.    ..|:..::.|.|..:...||.  ..:.:...:|.....
plant   568 SSLGQPSYPNPHLQ--DRAFPLDPNWVPSENPTVHNEHLQVREPLPGP--LLQTNLTAAPIMQTP 628

  Fly   961 LLQGGRGGHSCYVELADNGTSVH-RHGQGG--FGGGGGGCNTGGGGG--------GYAGGDVYLT 1014
            ::|                |||. :..|||  |    ...|||...|        ..|||
plant   629 VMQ----------------TSVESKLAQGGEQF----NYVNTGISNGVPYQDKPQPLAGG----- 668

  Fly  1015 ESNGEGGSSYISPSRSLREISEIHAGASSGPGAIIIIPAIEGCGCDYRCVALDEFRSKVRCICPD 1079
                         .:.:..:.|::..|::..||.:.:.         |...|.|....|:....:
plant   669 -------------KKDMGNLVEVNPSAATLEGAELSVE---------RLSFLPELMESVKRAALE 711

  Fly  1080 GWSLKRDNHTACEIR---EEAGKSSFQYLVSILMISLAVLFICIAALIFMLYNRYQRKKQSKKRH 1141
            |         |.|::   |||                                    |.|.:..
plant   712 G---------AAEVKAHPEEA------------------------------------KDQVRPE- 730

  Fly  1142 KMLVEQDLQLTRLRN----NIDDSNLNNFNPNYGCDGILNGHIDVNS--LPQVARDSLQLVNALG 1200
              |||.:.:....::    :.|..|.|||....     .....:..|  |..:..|.|:.:..||
plant   731 --LVENESEHMNAQDEPEIDSDSDNPNNFKIEQ-----TKAEAEAKSRGLQSIRNDDLEEIRELG 788

  Fly  1201 KGAFGEVYMALYRHRDGDAVEMGVAVKTLR------EDPKREK-EEDFLKEAAIMAKFNHPNMVH 1258
            .|.:|.||...::..|       ||:|.::      :..:||: .|||.|||.:::..:|||:|.
plant   789 HGTYGSVYHGKWKGSD-------VAIKRIKASCFAGKPSERERLIEDFWKEALLLSSLHHPNVVS 846

  Fly  1259 LIGVCFDRQPYYI--VLELLAGGDLQKFLRENRNTPERPSLLTMKDLLFCALDVAKGCRYMESKR 1321
            ..|:..|.....:  |.|.:..|.|::||::...|.:|      :..|..|:|.|.|..|:..|.
plant   847 FYGIVRDGPDGSLATVAEFMVNGSLKQFLQKKDRTIDR------RKRLIIAMDTAFGMEYLHGKN 905

  Fly  1322 FIHRDIAARNCLLSSKGPGR-VVKIADFGMSRDIYRSDYYRKGGKAMLPIKWMPPEAFLDG---I 1382
            .:|.|:...|.|::.:.|.| :.||.|.|:|: :.:......|.:..||  ||.|| .|.|   :
plant   906 IVHFDLKCENLLVNMRDPQRPICKIGDLGLSK-VKQKTLVSGGVRGTLP--WMAPE-LLSGKSNM 966

  Fly  1383 FTSKTDVWSFGILLWEVFSLGRSPYPGQHNTQVMELVVRGG-RLGSPTECPVSIYKVMADCWNPT 1446
            .:.|.||:||||::||:.: |..||...|...::..:|... |...|..|......:|..||...
plant   967 VSEKIDVYSFGIVMWELLT-GEEPYADMHCASIIGGIVNNALRPKIPQWCDPEWKGLMESCWTSE 1030

  Fly  1447 PEDRPTFITLLEHLTACTQDASIMN 1471
            |.:||:|..:.:.|...   |:.||
plant  1031 PTERPSFTEISQKLRTM---AAAMN 1052

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alk	NP_001261027.1	MAM	288..450	CDD:279023
		MAM	288..447	CDD:99706
		MAM	505..691	CDD:279023	26/115 (23%)
		MAM	505..689	CDD:99706	25/110 (23%)
		PTKc_ALK_LTK	1186..1462	CDD:270632	86/289 (30%)
		TyrKc	1193..1460	CDD:197581	84/280 (30%)
AT5G57610	NP_200569.1	PB1_UP2	27..123	CDD:99731
AT5G57610	NP_200569.1	STKc_MAP3K-like	787..1044	CDD:270901	83/274 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000